ID ZN852_HUMAN Reviewed; 543 AA.
AC Q6ZMS4; B4DLD7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2014, sequence version 4.
DT 30-NOV-2016, entry version 104.
DE RecName: Full=Zinc finger protein 852;
GN Name=ZNF852;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145, AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG59499.1; Type=Frameshift; Positions=494, 534; Evidence={ECO:0000305};
DR EMBL; AK296954; BAG59499.1; ALT_FRAME; mRNA.
DR EMBL; AC099669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001274278.1; NM_001287349.1.
DR UniGene; Hs.648974; -.
DR ProteinModelPortal; Q6ZMS4; -.
DR SMR; Q6ZMS4; -.
DR BioGrid; 130087; 4.
DR STRING; 9606.ENSP00000389841; -.
DR iPTMnet; Q6ZMS4; -.
DR PhosphoSitePlus; Q6ZMS4; -.
DR DMDM; 298286894; -.
DR EPD; Q6ZMS4; -.
DR MaxQB; Q6ZMS4; -.
DR PaxDb; Q6ZMS4; -.
DR PeptideAtlas; Q6ZMS4; -.
DR PRIDE; Q6ZMS4; -.
DR Ensembl; ENST00000436261; ENSP00000389841; ENSG00000178917.
DR Ensembl; ENST00000628759; ENSP00000487256; ENSG00000281626.
DR GeneID; 285346; -.
DR KEGG; hsa:285346; -.
DR UCSC; uc062iux.1; human.
DR CTD; 285346; -.
DR GeneCards; ZNF852; -.
DR HGNC; HGNC:27713; ZNF852.
DR HPA; HPA048312; -.
DR HPA; HPA049885; -.
DR neXtProt; NX_Q6ZMS4; -.
DR OpenTargets; ENSG00000178917; -.
DR OpenTargets; ENSG00000281626; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00860000133674; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q6ZMS4; -.
DR OMA; YWSSHLI; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q6ZMS4; -.
DR TreeFam; TF350837; -.
DR BioCyc; ZFISH:G66-32166-MONOMER; -.
DR GenomeRNAi; 285346; -.
DR PRO; PR:Q6ZMS4; -.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000178917; -.
DR Genevisible; Q6ZMS4; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Complete proteome; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1 543 Zinc finger protein 852.
FT /FTId=PRO_0000332125.
FT DOMAIN 8 82 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 159 181 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 187 209 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 215 237 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 243 265 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 271 293 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 299 321 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 327 349 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 355 377 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 383 405 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 411 433 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 439 461 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 467 489 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT MOD_RES 145 145 Phosphoserine.
FT {ECO:0000244|PubMed:23186163}.
FT CONFLICT 158 158 S -> P (in Ref. 1; BAG59499).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 159 181 ismart:ZnF_C2H2 [T]
FT MYHIT 467 489 ismart:ZnF_C2H2 [T]
FT MYHIT 217 237 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 271 293 ismart:ZnF_C2H2 [T]
FT MYHIT 159 186 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 383 410 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 357 377 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 8 82 iprf:KRAB [T]
FT MYHIT 355 382 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 8 67 ismart:KRAB [T]
FT MYHIT 8 48 ipfam:KRAB [T]
FT MYHIT 439 466 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 383 405 ismart:ZnF_C2H2 [T]
FT MYHIT 329 349 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 243 270 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 161 181 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 327 349 ismart:ZnF_C2H2 [T]
FT MYHIT 469 489 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 413 433 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 215 237 ismart:ZnF_C2H2 [T]
FT MYHIT 273 293 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 187 209 ismart:ZnF_C2H2 [T]
FT MYHIT 215 242 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 245 265 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 327 354 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 189 209 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 385 405 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 411 433 ismart:ZnF_C2H2 [T]
FT MYHIT 411 438 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 271 298 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 355 377 ismart:ZnF_C2H2 [T]
FT MYHIT 467 494 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 187 214 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 299 321 ismart:ZnF_C2H2 [T]
FT MYHIT 301 321 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 243 265 ismart:ZnF_C2H2 [T]
FT MYHIT 441 461 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 439 461 ismart:ZnF_C2H2 [T]
FT MYHIT 299 326 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 543 AA; 62084 MW; 4DE82359226B9414 CRC64;
MVRPQDTVAY EDLSEDYTQK KWKGLALSQR ALHWNMMLEN DRSMASLGRN MMESSELTPK
QEIFKGSESS NSTSGGLFGV VPGGTETGDV CEDTFKELEG QPSNEEGSRL ESDFLEIIDE
DKKKSTKDRY EEYKEVEEHP PLSSSPVEHE GVLKGQKSYR CDECGKAFYW SSHLIGHRRI
HTGEKPYECN ECGKTFRQTS QLIVHLRTHT GEKPYECSEC GKAYRHSSHL IQHQRLHNGE
KPYKCNECAK AFNQSSKLFD HQRTHTGEKP YECKECGAAF SRSKNLVRHQ FLHTGKKPYK
CNECGRAFCS NRNLIDHQRT HTGEKPYKCN ECGKAFSRSK CLIRHQSLHT GEKPYKCSEC
GKAFNQISQL VEHERIHTGE KPFKCSECGK AFGLSKCLIR HQRLHTSEKP YKCNECGKSF
NQNSYLIIHQ RIHTGEKPYE CNECGKVFSY NSSLMVHQRT HTGEKPYKCN SCGKAFSDSS
QLTVHQRVHT GEKNLMNVLS VGKPLVSVPL LITTSELMLE RSPQVWLGHL LKAWFSETDS
KDL
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