ID ZN843_HUMAN Reviewed; 348 AA.
AC Q8N446; A8K4U8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 30-NOV-2016, entry version 121.
DE RecName: Full=Zinc finger protein 843;
GN Name=ZNF843;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q16543:CDC37; NbExp=2; IntAct=EBI-6428016, EBI-295634;
CC -!- SIMILARITY: Contains 2 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR EMBL; AK291063; BAF83752.1; -; mRNA.
DR EMBL; BC036762; AAH36762.1; -; mRNA.
DR CCDS; CCDS45471.1; -.
DR RefSeq; NP_001129981.1; NM_001136509.1.
DR UniGene; Hs.722243; -.
DR ProteinModelPortal; Q8N446; -.
DR BioGrid; 129710; 5.
DR IntAct; Q8N446; 3.
DR STRING; 9606.ENSP00000322899; -.
DR iPTMnet; Q8N446; -.
DR PhosphoSitePlus; Q8N446; -.
DR BioMuta; ZNF843; -.
DR DMDM; 74759868; -.
DR PaxDb; Q8N446; -.
DR PRIDE; Q8N446; -.
DR DNASU; 283933; -.
DR Ensembl; ENST00000315678; ENSP00000322899; ENSG00000176723.
DR Ensembl; ENST00000618063; ENSP00000483573; ENSG00000176723.
DR GeneID; 283933; -.
DR KEGG; hsa:283933; -.
DR UCSC; uc010vfm.2; human.
DR CTD; 283933; -.
DR GeneCards; ZNF843; -.
DR HGNC; HGNC:28710; ZNF843.
DR HPA; HPA030911; -.
DR HPA; HPA030912; -.
DR neXtProt; NX_Q8N446; -.
DR OpenTargets; ENSG00000176723; -.
DR PharmGKB; PA162410853; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00530000067643; -.
DR HOGENOM; HOG000205472; -.
DR InParanoid; Q8N446; -.
DR OrthoDB; EOG091G093Q; -.
DR PhylomeDB; Q8N446; -.
DR BioCyc; ZFISH:ENSG00000176723-MONOMER; -.
DR ChiTaRS; ZNF843; human.
DR GenomeRNAi; 283933; -.
DR PRO; PR:Q8N446; -.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000176723; -.
DR CleanEx; HS_ZNF843; -.
DR ExpressionAtlas; Q8N446; baseline and differential.
DR Genevisible; Q8N446; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.160.60; -; 1.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1 348 Zinc finger protein 843.
FT /FTId=PRO_0000343750.
FT ZN_FING 33 55 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 145 167 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT COMPBIAS 210 259 Pro-rich.
FT CONFLICT 284 284 Q -> L (in Ref. 1; BAF83752).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 33 60 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 145 172 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 33 55 ipat:ZINC_FINGER_C2H2_1 [T]
SQ SEQUENCE 348 AA; 37065 MW; 34BC7ED6E61438A7 CRC64;
MRSLPFALTV ESVSARAPTC CSTGRFTQGR QPCKCKACGR GFTQSASLLQ HWRVHSDWRE
TLSLSPVRQD LLWPLQPHQA PASPLGRSHS SAGVRQGFSG QLCCWLTKEH TLAEALRLSP
VPAGFWGPVE ADRPPANSHR RVCPFCCCSC GDSVNEKTSL SQRVLPHPGE KTCRGGSVES
VSLAPSSVAP DSTSGLRPCG SPGSFLQHLP PSTLLPRPPF LYPGPPLSLQ PLVPSGLPAV
PAVPLGGLEV AQVPPATQPA AQQEGAMGPR SCASAGRDSR EAVQAPGYPE PARKASQHRA
AGPLGEARAR LQRQCRAPPP PSNPHWRGAL PVFPVWKASS RRSNLARH
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