ID ZN840_HUMAN Reviewed; 716 AA.
AC A6NDX5; Q6KAL7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 5.
DT 02-NOV-2016, entry version 74.
DE RecName: Full=Putative zinc finger protein 840;
DE AltName: Full=Zinc finger protein 840 pseudogene;
GN Name=ZNF840P; Synonyms=C20orf157, ZNF840;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 18 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
DR EMBL; AL031686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteinModelPortal; A6NDX5; -.
DR SMR; A6NDX5; -.
DR iPTMnet; A6NDX5; -.
DR PhosphoSitePlus; A6NDX5; -.
DR PRIDE; A6NDX5; -.
DR GeneCards; ZNF840P; -.
DR HGNC; HGNC:34344; ZNF840P.
DR neXtProt; NX_A6NDX5; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; A6NDX5; -.
DR PhylomeDB; A6NDX5; -.
DR BioCyc; ZFISH:G66-31211-MONOMER; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 20.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13912; zf-C2H2_6; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 5: Uncertain;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 716 Putative zinc finger protein 840.
FT /FTId=PRO_0000332148.
FT DOMAIN 42 113 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 151 173 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 207 229 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 235 257 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 277 299 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 305 327 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 333 355 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 361 383 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 389 411 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 417 439 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 445 467 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 473 495 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 501 523 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 549 571 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 577 599 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 605 627 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 633 655 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 661 683 C2H2-type 17. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 689 711 C2H2-type 18. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VARIANT 181 181 Y -> C (in dbSNP:rs3752261).
FT /FTId=VAR_048027.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 363 383 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 361 383 ismart:ZnF_C2H2 [T]
FT MYHIT 633 660 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 389 416 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 577 599 ismart:ZnF_C2H2 [T]
FT MYHIT 277 304 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 445 467 ismart:ZnF_C2H2 [T]
FT MYHIT 691 711 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 417 439 ismart:ZnF_C2H2 [T]
FT MYHIT 361 388 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 633 655 ismart:ZnF_C2H2 [T]
FT MYHIT 42 102 ismart:KRAB [T]
FT MYHIT 305 327 ismart:ZnF_C2H2 [T]
FT MYHIT 473 495 ismart:ZnF_C2H2 [T]
FT MYHIT 689 716 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 663 683 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 305 332 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 151 173 ismart:ZnF_C2H2 [T]
FT MYHIT 333 355 ismart:ZnF_C2H2 [T]
FT MYHIT 689 711 ismart:ZnF_C2H2 [T]
FT MYHIT 501 523 ismart:ZnF_C2H2 [T]
FT MYHIT 473 500 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 661 683 ismart:ZnF_C2H2 [T]
FT MYHIT 577 604 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 279 299 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 207 229 ismart:ZnF_C2H2 [T]
FT MYHIT 209 229 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 207 234 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 475 495 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 417 444 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 151 178 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 447 467 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 605 632 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 607 627 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 237 257 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 419 439 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 579 599 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 235 257 ismart:ZnF_C2H2 [T]
FT MYHIT 549 571 ismart:ZnF_C2H2 [T]
FT MYHIT 549 576 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 153 173 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 41 82 ipfam:KRAB [T]
FT MYHIT 605 627 ismart:ZnF_C2H2 [T]
FT MYHIT 307 327 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 235 262 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 551 571 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 391 411 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 42 113 iprf:KRAB [T]
FT MYHIT 277 299 ismart:ZnF_C2H2 [T]
FT MYHIT 445 472 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 501 528 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 661 688 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 333 360 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 635 655 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 503 523 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 335 355 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 389 411 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 716 AA; 83235 MW; 32A5D13B52610D4B CRC64;
MSLMGHGKVE MLLYAVPLLK APNCLSSSMQ LPHGGGRHQE LVRFRDVAVV FSPEEWDHLT
PEQRNLYKDV MLDNCKYLAS LGNWTYKAHV MSSLKQGKEP WMMEREVTGD PCPACQPALA
TFRALNESGN AFRQSFHHGE YRTHRTFVQH YECDDCGMAF GHVSQLTGHQ KIHKVGETHE
YGENTRGFRH RSSFTMLQRI CTLYKHFECN QCGETFNRPS KVIQHQSMHS GLKPYKCDVC
QKAFRFLSSL SIHQRFHVGN RVNLTRHQKT HTQRKPFSCN FCGKTFHRFS EKTQHLLIHT
RKKYYTCNYC KKEFNPYSKF ILHQRTHTGE KPHKCDVCEK SFKSISNLNK HQKTHTGEKP
FSCNECKKTF AQRTDLARHQ QIHTGKKSFI CSSCKKTFVR LSDLTQHKGT HTGERPYQCT
TCEKAFKYRS NFTKHQKTHS IGRPFACNEC GKTYRLNWEL NQHKKIHTGE KPYECGECGK
RFNNNSNLNK HKKIHTGEKH FVCNQCGKAF SLNSKLSRHQ RTHNKKENSS KSVSNLNKHQ
KTHAGEKPFP CNECKKAFAQ RMDLARHQQI HTGRKPFICS SCKKTFVRLS DLTQHKGTHT
GERPYQCTTC EKAFKYQSNF TKHQKTHSIG RPFTCNECGK TFRLNWKLNQ HKKIHTGEKP
YECGECGKCF NNNSNLSKHK KIHTGEKHFV CNQCGKAFSL NSKLSRHQIT HNKKKP
//
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