Entry sw:ZN785_HUMAN

ID   ZN785_HUMAN             Reviewed;         405 AA.
AC   A8K8V0; O75701; Q8IW91; Q8WV14; Q96MN0;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   30-NOV-2016, entry version 83.
DE   RecName: Full=Zinc finger protein 785;
GN   Name=ZNF785;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Peripheral blood monocyte, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   VARIANTS GLY-316 AND ARG-337.
RX   PubMed=26063658; DOI=10.1093/brain/awv155;
RA   Verdura E., Herve D., Scharrer E., del Mar Amador M.,
RA   Guyant-Marechal L., Philippi A., Corlobe A., Bergametti F., Gazal S.,
RA   Prieto-Morin C., Beaufort N., Le Bail B., Viakhireva I., Dichgans M.,
RA   Chabriat H., Haffner C., Tournier-Lasserve E.;
RT   "Heterozygous HTRA1 mutations are associated with autosomal dominant
RT   cerebral small vessel disease.";
RL   Brain 138:2347-2358(2015).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       A2ABF9:EHMT2; NbExp=3; IntAct=EBI-3925400, EBI-10174566;
CC       Q9UJC3:HOOK1; NbExp=3; IntAct=EBI-3925400, EBI-746704;
CC       P60370:KRTAP10-5; NbExp=3; IntAct=EBI-3925400, EBI-10172150;
CC       Q9UJV3-2:MID2; NbExp=3; IntAct=EBI-3925400, EBI-10172526;
CC       Q5JR59:MTUS2; NbExp=3; IntAct=EBI-3925400, EBI-742948;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A8K8V0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A8K8V0-2; Sequence=VSP_034965;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 7 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC   -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00119}.
DR   EMBL; AK056692; BAB71256.1; -; mRNA.
DR   EMBL; AK292465; BAF85154.1; -; mRNA.
DR   EMBL; CH471192; EAW52231.1; -; Genomic_DNA.
DR   EMBL; BC040642; AAH40642.1; -; mRNA.
DR   CCDS; CCDS10685.1; -. [A8K8V0-1]
DR   RefSeq; NP_689671.2; NM_152458.6. [A8K8V0-1]
DR   RefSeq; XP_016878456.1; XM_017022967.1. [A8K8V0-1]
DR   UniGene; Hs.513509; -.
DR   UniGene; Hs.710991; -.
DR   ProteinModelPortal; A8K8V0; -.
DR   SMR; A8K8V0; -.
DR   BioGrid; 126995; 72.
DR   IntAct; A8K8V0; 16.
DR   STRING; 9606.ENSP00000378642; -.
DR   iPTMnet; A8K8V0; -.
DR   PhosphoSitePlus; A8K8V0; -.
DR   BioMuta; ZNF785; -.
DR   PaxDb; A8K8V0; -.
DR   PRIDE; A8K8V0; -.
DR   DNASU; 146540; -.
DR   Ensembl; ENST00000395216; ENSP00000378642; ENSG00000197162. [A8K8V0-1]
DR   Ensembl; ENST00000470110; ENSP00000420340; ENSG00000197162. [A8K8V0-2]
DR   GeneID; 146540; -.
DR   KEGG; hsa:146540; -.
DR   UCSC; uc002dyv.3; human. [A8K8V0-1]
DR   CTD; 146540; -.
DR   GeneCards; ZNF785; -.
DR   HGNC; HGNC:26496; ZNF785.
DR   neXtProt; NX_A8K8V0; -.
DR   OpenTargets; ENSG00000197162; -.
DR   PharmGKB; PA162410467; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00560000077257; -.
DR   HOGENOM; HOG000234617; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; A8K8V0; -.
DR   KO; K09228; -.
DR   OMA; DCSLRFA; -.
DR   OrthoDB; EOG091G0P6J; -.
DR   PhylomeDB; A8K8V0; -.
DR   TreeFam; TF337922; -.
DR   BioCyc; ZFISH:G66-31623-MONOMER; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   ChiTaRS; ZNF785; human.
DR   GenomeRNAi; 146540; -.
DR   PRO; PR:A8K8V0; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000197162; -.
DR   CleanEx; HS_ZNF785; -.
DR   ExpressionAtlas; A8K8V0; baseline and differential.
DR   Genevisible; A8K8V0; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 3.30.160.60; -; 7.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    405       Zinc finger protein 785.
FT                                /FTId=PRO_0000345630.
FT   DOMAIN       29    100       KRAB. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00119}.
FT   ZN_FING     172    194       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     200    222       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     228    250       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     256    278       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     284    306       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     312    334       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     340    362       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   VAR_SEQ      98    112       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_034965.
FT   VARIANT     316    316       D -> G. {ECO:0000269|PubMed:26063658}.
FT                                /FTId=VAR_076389.
FT   VARIANT     337    337       S -> R (in dbSNP:rs201574418).
FT                                {ECO:0000269|PubMed:26063658}.
FT                                /FTId=VAR_076390.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       172    199       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       228    255       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       172    194       ismart:ZnF_C2H2 [T]
FT   MYHIT       286    306       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       256    283       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT        29    100       iprf:KRAB [T]
FT   MYHIT       340    362       ismart:ZnF_C2H2 [T]
FT   MYHIT       284    311       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       230    250       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       256    278       ismart:ZnF_C2H2 [T]
FT   MYHIT       202    222       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT        29     69       ipfam:KRAB [T]
FT   MYHIT       228    250       ismart:ZnF_C2H2 [T]
FT   MYHIT       340    367       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       258    278       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       284    306       ismart:ZnF_C2H2 [T]
FT   MYHIT       174    194       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       200    227       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT        29     89       ismart:KRAB [T]
FT   MYHIT       312    334       ismart:ZnF_C2H2 [T]
FT   MYHIT       342    362       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       200    222       ismart:ZnF_C2H2 [T]
FT   MYHIT       314    334       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       312    339       iprf:ZINC_FINGER_C2H2_2 [T]
SQ   SEQUENCE   405 AA;  46168 MW;  521391E814B117F0 CRC64;
     MGPPLAPRPA HVPGEAGPRR TRESRPGAVS FADVAVYFSP EEWECLRPAQ RALYRDVMRE
     TFGHLGALGF SVPKPAFISW VEGEVEAWSP EAQDPDGESS AAFSRGQGQE AGSRDGNEEK
     ERLKKCPKQK EVAHEVAVKE WWPSVACPEF CNPRQSPMNP WLKDTLTRRL PHSCPDCGRN
     FSYPSLLASH QRVHSGERPF SCGQCQARFS QRRYLLQHQF IHTGEKPYPC PDCGRRFRQR
     GSLAIHRRAH TGEKPYACSD CKSRFTYPYL LAIHQRKHTG EKPYSCPDCS LRFAYTSLLA
     IHRRIHTGEK PYPCPDCGRR FTYSSLLLSH RRIHSDSRPF PCVECGKGFK RKTALEAHRW
     IHRSCSERRA WQQAVVGRSE PIPVLGGKDP PVHFRHFPDI FQECG
//