ID ZN781_HUMAN Reviewed; 355 AA.
AC Q8N8C0; Q2VPJ8;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 02-NOV-2016, entry version 115.
DE RecName: Full=Zinc finger protein 781;
GN Name=ZNF781;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N8C0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8C0-2; Sequence=VSP_026560;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 4 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR EMBL; AK097019; BAC04927.1; -; mRNA.
DR EMBL; BC108687; AAI08688.1; -; mRNA.
DR CCDS; CCDS12507.1; -. [Q8N8C0-2]
DR RefSeq; NP_689818.2; NM_152605.3. [Q8N8C0-2]
DR UniGene; Hs.722657; -.
DR ProteinModelPortal; Q8N8C0; -.
DR SMR; Q8N8C0; -.
DR IntAct; Q8N8C0; 1.
DR STRING; 9606.ENSP00000351391; -.
DR iPTMnet; Q8N8C0; -.
DR PhosphoSitePlus; Q8N8C0; -.
DR BioMuta; ZNF781; -.
DR DMDM; 74760005; -.
DR PaxDb; Q8N8C0; -.
DR PeptideAtlas; Q8N8C0; -.
DR PRIDE; Q8N8C0; -.
DR Ensembl; ENST00000358582; ENSP00000351391; ENSG00000196381. [Q8N8C0-2]
DR Ensembl; ENST00000590008; ENSP00000466370; ENSG00000196381. [Q8N8C0-2]
DR GeneID; 163115; -.
DR KEGG; hsa:163115; -.
DR UCSC; uc002ogy.3; human. [Q8N8C0-1]
DR CTD; 163115; -.
DR GeneCards; ZNF781; -.
DR HGNC; HGNC:26745; ZNF781.
DR HPA; HPA062512; -.
DR neXtProt; NX_Q8N8C0; -.
DR OpenTargets; ENSG00000196381; -.
DR PharmGKB; PA162410427; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00530000064407; -.
DR HOGENOM; HOG000234617; -.
DR InParanoid; Q8N8C0; -.
DR OMA; NIREHIL; -.
DR OrthoDB; EOG091G05RN; -.
DR PhylomeDB; Q8N8C0; -.
DR TreeFam; TF340562; -.
DR BioCyc; ZFISH:ENSG00000180419-MONOMER; -.
DR GenomeRNAi; 163115; -.
DR PRO; PR:Q8N8C0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000196381; -.
DR ExpressionAtlas; Q8N8C0; baseline and differential.
DR Genevisible; Q8N8C0; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 4.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 355 Zinc finger protein 781.
FT /FTId=PRO_0000293693.
FT ZN_FING 33 55 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 61 83 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 89 111 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 117 133 C2H2-type 4; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT VAR_SEQ 328 355 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_026560.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 89 116 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 33 60 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 63 83 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 91 111 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 33 55 ismart:ZnF_C2H2 [T]
FT MYHIT 61 88 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 61 83 ismart:ZnF_C2H2 [T]
FT MYHIT 89 111 ismart:ZnF_C2H2 [T]
FT MYHIT 35 55 ipat:ZINC_FINGER_C2H2_1 [T]
SQ SEQUENCE 355 AA; 41526 MW; 728D243A9F9F0DB1 CRC64;
MQRNAMYLKN VAETACNFQL TQYQISHANQ KPYECQICGK PFRKRAHLTQ HNRIHTGGKP
YECKECGKVF ICCSTLIQHK RTHTSEKPYE CLECRKTFRR SAHLIRHQRI HTGEKPYKCK
QCWKAFASVS DLIDIGKFTL MRDFTNVQNV GRHLTIAQLL FSIREFTLVR SPLNVRNVAK
HSIIAQHLLN TRELILMRNL MNVRNVKRLL GKVHILLNIK EFILVRNHMS VSNVGRLSLV
FLILIDIREF TLVKNPMNVK NVVELLTIVQ LLFNTREFTL VRRLMNISSV GRFLSPVQHL
FNIREHILMK NLMNVSNARR PSSIMHILFD IKEFILVRNL INVSNVGRPL LLFLI
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