ID ZN750_XENLA Reviewed; 674 AA.
AC Q32N19; Q7ZYL3;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 06-JUL-2016, entry version 34.
DE RecName: Full=Zinc finger protein 750;
GN Name=znf750;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor involved in epidermis
CC differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Contains 1 C2H2-type zinc finger. {ECO:0000305}.
DR EMBL; BC043737; AAH43737.1; -; mRNA.
DR EMBL; BC108879; AAI08880.1; -; mRNA.
DR RefSeq; NP_001079466.1; NM_001085997.1.
DR UniGene; Xl.7756; -.
DR GeneID; 379153; -.
DR KEGG; xla:379153; -.
DR CTD; 379153; -.
DR Xenbase; XB-GENE-5775750; znf750.
DR HOVERGEN; HBG080198; -.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001046; F:core promoter sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Activator; Differentiation; Metal-binding; Nucleus; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 674 Zinc finger protein 750.
FT /FTId=PRO_0000247073.
FT ZN_FING 25 46 C2H2-type; degenerate.
FT CONFLICT 74 74 N -> K (in Ref. 1; AAH43737).
FT {ECO:0000305}.
SQ SEQUENCE 674 AA; 74646 MW; E981AA59B84E7A34 CRC64;
MSLMKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITVVTDQD
RIIKNPKVNS MDQNQTSNEP FAKSSVPAIN SSLESKMLHS VAREEAKENL DLKNEPKSHA
EKTTVSKEFT LSPPVAISQI NKPPSLDGVM RPSAFIPVGE HRVKKGAENR TIPELTSISA
EPAKGVHSIK SAFHSLPTPW KSGLVSPDFS QKSSIPRYIR PMISEYPPQF YSEAGLPAVF
SPYLFPQTEC ENPMLSIYST PDQRPYLPHP LQPSGLPLPK PINAPFEHYR LLQQFQQNPQ
LHYGFYRPTE HPYFSYGLKV PPAPGLSKEH TSQSMDSPTF IYPSSHPSRL YPLEGFQKLF
EIQKETPPVL AKNLDSKSDS ESVKMSPRAG SAATGSPERP SPTNFTQSSQ GHEGIFDLST
KSISTSDKIG KDFTSGKAMR KSTDSQTIIS RENSPSFGND GVQSHSEGIT VTDDAVHDDT
IAPLNLSKKS EVESRDIVDT VNNSDFTNER VGFMEMQDLP LNLSVKDSGS NHNTLCADER
VLLPRQSTSP PVYQAIQTTD NRAPTTTGIH SLGIIENCDE QKQSAAVALC QLATSSPGVP
PRGTEDEFPE KETVVPEQVQ PRSPAAQETE TDVGARGQKR TNSKELGKSQ SSTKKQKAVD
SGRMFTLRKR PRVS
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