ID ZN750_BOVIN Reviewed; 703 AA.
AC A2VDR9;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 07-SEP-2016, entry version 48.
DE RecName: Full=Zinc finger protein 750;
GN Name=ZNF750;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor involved in epidermis
CC differentiation. Required for terminal epidermal differentiation:
CC acts downstream of p63/TP63 and activates expression of late
CC epidermal differentiation genes. Specifically binds to the
CC promoter of KLF4 and promotes its expression (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Contains 1 C2H2-type zinc finger. {ECO:0000305}.
DR EMBL; BC133373; AAI33374.1; -; mRNA.
DR RefSeq; NP_001075002.1; NM_001081533.1.
DR UniGene; Bt.91538; -.
DR STRING; 9913.ENSBTAP00000034629; -.
DR PaxDb; A2VDR9; -.
DR PRIDE; A2VDR9; -.
DR Ensembl; ENSBTAT00000034744; ENSBTAP00000034629; ENSBTAG00000015406.
DR GeneID; 535628; -.
DR KEGG; bta:535628; -.
DR CTD; 79755; -.
DR eggNOG; ENOG410IF50; Eukaryota.
DR eggNOG; ENOG410ZK89; LUCA.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; HOG000049178; -.
DR HOVERGEN; HBG080198; -.
DR InParanoid; A2VDR9; -.
DR OMA; HYRFFQQ; -.
DR OrthoDB; EOG091G036R; -.
DR TreeFam; TF331381; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000015406; -.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001046; F:core promoter sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Activator; Complete proteome; Differentiation; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1 703 Zinc finger protein 750.
FT /FTId=PRO_0000284952.
FT ZN_FING 25 46 C2H2-type; degenerate.
SQ SEQUENCE 703 AA; 75167 MW; 621465798EB98152 CRC64;
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
RVPKCSKPNS SDPKQTNQPD PVVKPTSSKP VPSGLSHLDA KLQHSLAKDD IKENLDLHAR
GPHRCLGQKP TPHKEAAPPS PAPEAAVGTQ PVLEGAVRPS AFVPVGEHRL KGQELTETPE
ALALTHAPAK ASSFHTKSAF HAPGYPWRAG SPFLTPEFPH KIPSTKGFGA TSPYVHPSIT
EYPPHFYTEH GLATIYSPYL LAGNSPECDS PLLSVYGAQD QRHFLPHPGP IPKHLNPAPS
TYDHYRFFQQ YHSSLPIPYG FYRPESAFSS YGLRLPPVAG ISRDQSSHLL EEAALGYQAL
SPSKLNSSNS HKKHTELEKQ SPTPEAKEPS KDGQRDTEGT KMSPRAGSAA TGSPGRPSPT
NFTQTSQPCA GLCGLSDAPA SSAPGRIPPP EQGLAAFKPI KKNTEHPHSQ APENRAVSPK
SLEALSTDAP TQLGSLEAAP SSPEDGSRAA PLNLSTKPEA EPAATCSPAH GGFVEPQDAP
LNLSVKDPCN ALTSRPSVCS PPRGAEPAAA PTPSPTQQRE PASSGDGPDP SSVEAPVPSP
TGKAQDIRAA DSDEQKQTAA VALCQLAAYS PGNVEPAAQE PTCRPDAPTP RAPESQEAQC
DLRPKGQKRT SPREVGKGQQ GSKKAKPSDT ARVFTLRKRT RVS
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