ID ZN672_HUMAN Reviewed; 452 AA.
AC Q499Z4; Q96H65; Q96IM3; Q9H6G5;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 30-NOV-2016, entry version 105.
DE RecName: Full=Zinc finger protein 672;
GN Name=ZNF672;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Epithelium, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, Lymph, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q499Z4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q499Z4-2; Sequence=VSP_018161, VSP_018162;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 14 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR EMBL; AK025954; BAB15294.1; -; mRNA.
DR EMBL; AK027679; BAB55290.1; -; mRNA.
DR EMBL; BC007385; AAH07385.2; -; mRNA.
DR EMBL; BC008872; AAH08872.1; -; mRNA.
DR EMBL; BC035140; AAH35140.1; -; mRNA.
DR EMBL; BC050348; AAH50348.1; -; mRNA.
DR EMBL; BC068506; AAH68506.1; -; mRNA.
DR CCDS; CCDS1638.1; -. [Q499Z4-1]
DR RefSeq; NP_079112.1; NM_024836.2. [Q499Z4-1]
DR RefSeq; XP_005270393.1; XM_005270336.1. [Q499Z4-1]
DR UniGene; Hs.521151; -.
DR ProteinModelPortal; Q499Z4; -.
DR SMR; Q499Z4; -.
DR BioGrid; 122978; 2.
DR IntAct; Q499Z4; 3.
DR STRING; 9606.ENSP00000421915; -.
DR iPTMnet; Q499Z4; -.
DR PhosphoSitePlus; Q499Z4; -.
DR BioMuta; ZNF672; -.
DR DMDM; 116242864; -.
DR EPD; Q499Z4; -.
DR MaxQB; Q499Z4; -.
DR PaxDb; Q499Z4; -.
DR PeptideAtlas; Q499Z4; -.
DR PRIDE; Q499Z4; -.
DR Ensembl; ENST00000306562; ENSP00000421915; ENSG00000171161. [Q499Z4-1]
DR GeneID; 79894; -.
DR KEGG; hsa:79894; -.
DR UCSC; uc001iex.4; human. [Q499Z4-1]
DR CTD; 79894; -.
DR GeneCards; ZNF672; -.
DR HGNC; HGNC:26179; ZNF672.
DR HPA; HPA055779; -.
DR HPA; HPA062506; -.
DR neXtProt; NX_Q499Z4; -.
DR OpenTargets; ENSG00000171161; -.
DR PharmGKB; PA142670473; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00730000111556; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q499Z4; -.
DR OMA; HQGERPH; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q499Z4; -.
DR TreeFam; TF337999; -.
DR ChiTaRS; ZNF672; human.
DR GenomeRNAi; 79894; -.
DR PRO; PR:Q499Z4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000171161; -.
DR CleanEx; HS_ZNF672; -.
DR ExpressionAtlas; Q499Z4; baseline and differential.
DR Genevisible; Q499Z4; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 1.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 452 Zinc finger protein 672.
FT /FTId=PRO_0000233991.
FT ZN_FING 14 36 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 42 64 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 70 92 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 99 122 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 128 150 C2H2-type 5; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 163 185 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 199 221 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 227 249 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 255 277 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 283 305 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 311 333 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 339 361 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 367 389 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 395 417 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 128 223 RRCPLCARTFRQSALLFHQARAHPLGTTSDPAAPPHRCAQC
FT PRAFRSGAGLRSHARIHVSRSPTRPRVSDAHQCGVCGKCFG
FT KSSTLTRHLQTHSG -> LLPCCPRITRILSSGVGAGSQGT
FT LRLPCVQEPRCWCVPLMLLCSLVFLIFLPLFCLLLSYLIPA
FT HIFSFPDYFCCPASSGNGHRFGCRHVTSPVAS (in
FT isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_018161.
FT VAR_SEQ 224 452 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_018162.
FT CONFLICT 182 182 A -> P (in Ref. 2; AAH50348/AAH35140).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 255 282 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 199 226 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 72 92 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 163 185 ismart:ZnF_C2H2 [T]
FT MYHIT 70 92 ismart:ZnF_C2H2 [T]
FT MYHIT 339 361 ismart:ZnF_C2H2 [T]
FT MYHIT 397 417 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 311 333 ismart:ZnF_C2H2 [T]
FT MYHIT 163 190 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 70 92 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 44 64 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 367 394 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 285 305 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 313 333 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 283 310 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 283 305 ismart:ZnF_C2H2 [T]
FT MYHIT 16 36 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 201 221 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 367 389 ismart:ZnF_C2H2 [T]
FT MYHIT 99 122 ismart:ZnF_C2H2 [T]
FT MYHIT 42 69 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 14 41 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 227 254 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 395 417 ismart:ZnF_C2H2 [T]
FT MYHIT 128 150 ismart:ZnF_C2H2 [T]
FT MYHIT 227 249 ismart:ZnF_C2H2 [T]
FT MYHIT 99 127 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 229 249 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 339 366 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 165 185 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 199 221 ismart:ZnF_C2H2 [T]
FT MYHIT 395 422 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 311 338 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 255 277 ismart:ZnF_C2H2 [T]
FT MYHIT 99 122 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 42 64 ismart:ZnF_C2H2 [T]
FT MYHIT 14 36 ismart:ZnF_C2H2 [T]
FT MYHIT 257 277 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 341 361 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 369 389 ipat:ZINC_FINGER_C2H2_1 [T]
SQ SEQUENCE 452 AA; 50224 MW; 4D9D8B262748A39E CRC64;
MFATSGAVAA GKPYSCSECG KSFCYSSVLL RHERAHGGDG RFRCLECGER CARAADLRAH
RRTHAGQTLY ICSECGQSFR HSGRLDLHLG AHRQRCRTCP CRTCGRRFPH LPALLLHRRR
QHLPERPRRC PLCARTFRQS ALLFHQARAH PLGTTSDPAA PPHRCAQCPR AFRSGAGLRS
HARIHVSRSP TRPRVSDAHQ CGVCGKCFGK SSTLTRHLQT HSGEKPFKCP ECGKGFLESA
TLVRHQRTHT GEKPYACGDC GRCFSESSTL LRHRRSHQGE RPHACATCGK GFGQRSDLVV
HQRIHTGEKP FACPECGRRF SDRSDLTKHR RTHTGEKPYR CELCGKRFTC VSNLNVHRRN
HAGHKPHKCP ECSKAFSVAS KLALHRKTHL GERPAECAEC GKCFSHSRSL SQHQRAHTRA
RTAAAVAIQS AVGTALVFEG PAEQEKPGFS VS
//
|
