Entry sw:ZN654_MOUSE

ID   ZN654_MOUSE             Reviewed;         571 AA.
AC   Q9DAU9; Q8K390;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 2.
DT   30-NOV-2016, entry version 122.
DE   RecName: Full=Zinc finger protein 654;
GN   Name=Znf654; Synonyms=Zfp654;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Placenta;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Embryo, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-566 AND SER-570, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-566 AND SER-570, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH27760.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AK005508; BAB24088.2; -; mRNA.
DR   EMBL; BC027760; AAH27760.1; ALT_INIT; mRNA.
DR   EMBL; BC068018; AAH68018.1; -; mRNA.
DR   CCDS; CCDS49883.1; -.
DR   RefSeq; NP_082335.1; NM_028059.2.
DR   UniGene; Mm.25960; -.
DR   ProteinModelPortal; Q9DAU9; -.
DR   SMR; Q9DAU9; -.
DR   STRING; 10090.ENSMUSP00000052946; -.
DR   iPTMnet; Q9DAU9; -.
DR   PhosphoSitePlus; Q9DAU9; -.
DR   EPD; Q9DAU9; -.
DR   PaxDb; Q9DAU9; -.
DR   PeptideAtlas; Q9DAU9; -.
DR   PRIDE; Q9DAU9; -.
DR   Ensembl; ENSMUST00000052588; ENSMUSP00000052946; ENSMUSG00000047141.
DR   GeneID; 72020; -.
DR   KEGG; mmu:72020; -.
DR   UCSC; uc007zqd.1; mouse.
DR   CTD; 72020; -.
DR   MGI; MGI:1919270; Zfp654.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00840000129803; -.
DR   HOGENOM; HOG000170898; -.
DR   HOVERGEN; HBG108772; -.
DR   InParanoid; Q9DAU9; -.
DR   OrthoDB; EOG091G0B4Q; -.
DR   PhylomeDB; Q9DAU9; -.
DR   TreeFam; TF326007; -.
DR   PRO; PR:Q9DAU9; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   Bgee; ENSMUSG00000047141; -.
DR   CleanEx; MM_ZFP654; -.
DR   ExpressionAtlas; Q9DAU9; baseline and differential.
DR   Genevisible; Q9DAU9; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 1.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    571       Zinc finger protein 654.
FT                                /FTId=PRO_0000311947.
FT   ZN_FING      25     47       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     197    222       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     238    260       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     266    290       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     295    319       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS    154    159       Poly-Glu.
FT   MOD_RES     566    566       Phosphoserine.
FT                                {ECO:0000244|PubMed:17242355,
FT                                ECO:0000244|PubMed:21183079}.
FT   MOD_RES     570    570       Phosphoserine.
FT                                {ECO:0000244|PubMed:17242355,
FT                                ECO:0000244|PubMed:21183079}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       295    319       ismart:ZnF_C2H2 [T]
FT   MYHIT        27     47       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       197    222       ismart:ZnF_C2H2 [T]
FT   MYHIT       266    290       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT        25     52       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       534    554       ismart:ZnF_C2H2 [T]
FT   MYHIT       199    222       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       266    290       ismart:ZnF_C2H2 [T]
FT   MYHIT        25     47       ismart:ZnF_C2H2 [T]
FT   MYHIT       297    319       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       197    222       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       238    260       ismart:ZnF_C2H2 [T]
FT   MYHIT       268    290       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       240    260       ipat:ZINC_FINGER_C2H2_1 [T]
SQ   SEQUENCE   571 AA;  65164 MW;  1B9B67F83B8347A6 CRC64;
     MLCNKEFLGG HIVRHAQAHQ KKGSFACVIC GRKFRNRGLM QKHLKNHVKK IQRQQIATAQ
     QDDPEVITLE EINGSKSLIS FENGNSNTKG LEIETLTASS ERNKEVIREH MAEFIKIPIA
     IPENAIENII ENGKPDASFN NISESLPQCD DDYEEEENED DYEDDYDLNQ ETSVLHKING
     TVCHPKDVYA TDQEGNFKCP ALGCVRIFKR IGFLNMHART VHPTDLNVRQ TVMKWSKGKC
     KFCQRQFEDS QHFIDHLNRH SYPNVYFCLH FNCNESFKLP FQLAQHTKSH RIFQAQCSFP
     ECHELFEDLP LLYEHEAQHY LSKTPESSAQ LSEVVPNHQE IDPFSNENQT IHHPVSTSKS
     RKYSTEPKTY IDTMEKKTDS LVHNGNEHSD DTVSNISLID QKMPAIEPNP ENTHSTTDLV
     NGHSEIEQTP LVTSDPTLKI DINRNRTENG SILPSVESQE HSALSVSQAP SKPNLTSEQT
     SYGLIVTKPF VRPLPPSYLD ERYLSMPKRR KFLTDIVDAC SDQDNMYKKP VKRLRCGKCL
     TTYCNAEALE AHLAQKKCQT LFGFDSDDES A
//