Entry sw:ZN654_HUMAN

ID   ZN654_HUMAN             Reviewed;         581 AA.
AC   Q8IZM8; Q9H791; Q9NV14;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   30-NOV-2016, entry version 115.
DE   RecName: Full=Zinc finger protein 654;
DE   AltName: Full=Melanoma-associated antigen;
GN   Name=ZNF654;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bruno R., d'Orlando O., Altomonte A., Lamaj E., Maio M., Pucillo C.;
RT   "Study of the immune profile in metastatic melanoma patients immunized
RT   with anti-idiotypic antibody by SEREX analysis.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-581.
RC   TISSUE=Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN40504.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC       Sequence=BAA91946.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC       Sequence=BAB15007.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
DR   EMBL; AF543494; AAN40504.1; ALT_INIT; mRNA.
DR   EMBL; AK001859; BAA91946.1; ALT_INIT; mRNA.
DR   EMBL; AK024795; BAB15007.1; ALT_INIT; mRNA.
DR   EMBL; AC119733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC128650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS46874.1; -.
DR   RefSeq; NP_060763.2; NM_018293.2.
DR   UniGene; Hs.591650; -.
DR   UniGene; Hs.661116; -.
DR   ProteinModelPortal; Q8IZM8; -.
DR   SMR; Q8IZM8; -.
DR   STRING; 9606.ENSP00000312141; -.
DR   iPTMnet; Q8IZM8; -.
DR   PhosphoSitePlus; Q8IZM8; -.
DR   BioMuta; ZNF654; -.
DR   DMDM; 296453064; -.
DR   EPD; Q8IZM8; -.
DR   MaxQB; Q8IZM8; -.
DR   PaxDb; Q8IZM8; -.
DR   PeptideAtlas; Q8IZM8; -.
DR   PRIDE; Q8IZM8; -.
DR   DNASU; 55279; -.
DR   Ensembl; ENST00000309495; ENSP00000312141; ENSG00000175105.
DR   GeneID; 55279; -.
DR   KEGG; hsa:55279; -.
DR   UCSC; uc003dqv.4; human.
DR   CTD; 55279; -.
DR   DisGeNET; 55279; -.
DR   GeneCards; ZNF654; -.
DR   HGNC; HGNC:25612; ZNF654.
DR   HPA; HPA036172; -.
DR   HPA; HPA036173; -.
DR   neXtProt; NX_Q8IZM8; -.
DR   OpenTargets; ENSG00000175105; -.
DR   PharmGKB; PA134923001; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00840000129803; -.
DR   HOGENOM; HOG000170898; -.
DR   HOVERGEN; HBG108772; -.
DR   InParanoid; Q8IZM8; -.
DR   OMA; TECGDDY; -.
DR   OrthoDB; EOG091G0B4Q; -.
DR   PhylomeDB; Q8IZM8; -.
DR   TreeFam; TF326007; -.
DR   GenomeRNAi; 55279; -.
DR   PRO; PR:Q8IZM8; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000175105; -.
DR   CleanEx; HS_ZNF654; -.
DR   Genevisible; Q8IZM8; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 1.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    581       Zinc finger protein 654.
FT                                /FTId=PRO_0000311946.
FT   ZN_FING      25     47       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     199    224       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     240    262       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     268    292       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     297    321       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS     75     80       Poly-Ser.
FT   COMPBIAS    154    160       Poly-Glu.
FT   MOD_RES     576    576       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9DAU9}.
FT   MOD_RES     580    580       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9DAU9}.
FT   CONFLICT    258    258       H -> Q (in Ref. 2; BAA91946).
FT                                {ECO:0000305}.
FT   CONFLICT    294    294       I -> T (in Ref. 1; AAN40504 and 2;
FT                                BAA91946). {ECO:0000305}.
FT   CONFLICT    548    548       K -> E (in Ref. 2; BAB15007).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        25     52       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       270    292       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       268    292       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       199    224       ismart:ZnF_C2H2 [T]
FT   MYHIT       297    321       ismart:ZnF_C2H2 [T]
FT   MYHIT       201    224       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       299    321       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       268    292       ismart:ZnF_C2H2 [T]
FT   MYHIT        25     47       ismart:ZnF_C2H2 [T]
FT   MYHIT        27     47       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       544    564       ismart:ZnF_C2H2 [T]
FT   MYHIT       242    262       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       240    262       ismart:ZnF_C2H2 [T]
SQ   SEQUENCE   581 AA;  65854 MW;  8B1FE6C4B1A72A12 CRC64;
     MLCNKEFLGG HIVRHAQAHQ KKGSFACVIC GRKFRNRGLM QKHLKNHVKK IQRQQIAAAQ
     QDDQEVTALE EINCSSSSIS FENGNSDSKD LEVETLTASS EGNKEVIPEH VAEFIEIPIS
     VPEDVIENVI ENGSPNNSLN NVFKPLTECG DDYEEEEDEE GDYEEDDYDL NQETSVIHKI
     NGTVCHPKDI YATDQEGNFK CPALGCVRIF KRIGFLNKHA MTVHPTDLNV RQTVMKWSKG
     KCKFCQRQFE DSQHFIDHLN RHSYPNVYFC LHFNCNESFK LPFQLAQHTK SHRIFQAQCS
     FPECHELFED LPLLYEHEAQ HYLSKTPESS AQPSETILWD VQTDSNPNQE KDSSSNEKQT
     ISLPVSTSKS RKESTEPKTC IESMEKKTDS LVQNGNERSD DTVSNISLID QKMPDIEPNS
     ENNCSSSDIV NGHSEIEQTP LVSSDPALKI DTNRIRTENG SILPSVVPQE HNTLPVSQAP
     SKPNLTSEHT SYGLILTKPY VRPLPPSYLD ERYLSMPKRR KFLTDRVDAC SDQDNVYKKS
     VKRLRCGKCL TTYCNAEALE AHLAQKKCQT LFGFDSDDES A
//