Legends: 1, KRAB. {ECO:0000255|PROSITE- ProRule:PRU00119}; 2, ZN_FING C2H2-type 1; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 3, ZN_FING C2H2-type 2; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 4, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ismart:ZnF_C2H2 [T]; 15, iprf:ZINC_FINGER_C2H2_2 [T]; 16, ipfam:KRAB [T]; 17, ipat:ZINC_FINGER_C2H2_1 [T]; 18, ismart:KRAB [T].
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ID ZN614_PONAB Reviewed; 585 AA.
AC Q5RCJ2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 05-OCT-2016, entry version 71.
DE RecName: Full=Zinc finger protein 614;
GN Name=ZNF614;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
DR EMBL; CR858278; CAH90515.1; -; mRNA.
DR RefSeq; NP_001125272.1; NM_001131800.1.
DR UniGene; Pab.13662; -.
DR ProteinModelPortal; Q5RCJ2; -.
DR STRING; 9601.ENSPPYP00000011573; -.
DR PRIDE; Q5RCJ2; -.
DR GeneID; 100172169; -.
DR KEGG; pon:100172169; -.
DR CTD; 80110; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q5RCJ2; -.
DR KO; K09228; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 11.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 585 Zinc finger protein 614.
FT /FTId=PRO_0000234600.
FT DOMAIN 8 79 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 205 227 C2H2-type 1; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 257 281 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 287 309 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 315 337 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 343 365 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 371 393 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 399 421 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 427 449 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 455 477 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 483 505 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 511 533 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 539 561 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 399 421 ismart:ZnF_C2H2 [T]
FT MYHIT 399 426 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 8 79 iprf:KRAB [T]
FT MYHIT 7 48 ipfam:KRAB [T]
FT MYHIT 427 454 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 539 561 ismart:ZnF_C2H2 [T]
FT MYHIT 289 309 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 345 365 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 371 398 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 511 538 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 429 449 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 343 365 ismart:ZnF_C2H2 [T]
FT MYHIT 373 393 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 485 505 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 315 342 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 427 449 ismart:ZnF_C2H2 [T]
FT MYHIT 317 337 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 401 421 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 483 510 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 457 477 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 371 393 ismart:ZnF_C2H2 [T]
FT MYHIT 287 314 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 8 68 ismart:KRAB [T]
FT MYHIT 455 482 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 511 533 ismart:ZnF_C2H2 [T]
FT MYHIT 483 505 ismart:ZnF_C2H2 [T]
FT MYHIT 315 337 ismart:ZnF_C2H2 [T]
FT MYHIT 343 370 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 455 477 ismart:ZnF_C2H2 [T]
FT MYHIT 539 566 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 513 533 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 541 561 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 287 309 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 585 AA; 67327 MW; AB54DBD4786585A2 CRC64;
MIKTQESLTL EDVAVEFSWE EWQLLDTAQK NLYRDVMVEN YNHLVSLGYQ TSKPDVLSKL
AHGQEPWITD AKIQNKNCPG IRKVDSHLQE HSPNQRLLKS VQQCNGQNTL RNIVRLSKTH
FPIVQNHDTF DLYRKNLKSS LSLINQKRRH GINNPVEFIG GEKTLLHGKH ECTHTKTRYS
ENAKRIHTKF QAFKHQRTQK IEKPHACIEC EQTFFRKSQL IYLENICIQE NPGSGQCEKL
SRSVLFTKHL KTNTRDKICI PNEYRKGSTV KSSLITHQET HTEEKSYMCS ECGKGFTMKR
YLIAHQRTHS GEKPYVCNEC GKGFTVKSNL IVHQRTHTGE KPYICSECGK GFTMKRYLVV
HQRTHTGEKP YMCSECGKGF TVKSNLIVHQ RSHTGEKSYI CSECGKGFTV KRTLIIHQRT
HTGEKSYICN ECGKGFTTKR TLIIHQRTHT GEKPYECNEC GKAFSQKICL IQHGRCHTGK
TPFVCTECGK SYSHKYGLIT HQRIHTGEKP YECNECGKAF TTKSVLNVHQ RTHTGERPYG
CSDCEKAFSH LSNLVKHKKM HTREMGRISQ VENSCNGESQ LLPYK
//
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