Legends: 1, KRAB. {ECO:0000255|PROSITE- ProRule:PRU00119}; 2, ZN_FING C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042}; 3, ZN_FING C2H2-type 2; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 4, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ipat:ZINC_FINGER_C2H2_1 [T]; 15, iprf:ZINC_FINGER_C2H2_2 [T]; 16, ismart:ZnF_C2H2 [T]; 17, ipfam:KRAB [T]; 18, ismart:KRAB [T].
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ID ZN614_MACFA Reviewed; 582 AA.
AC Q95K49;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 05-OCT-2016, entry version 72.
DE RecName: Full=Zinc finger protein 614;
GN Name=ZNF614; ORFNames=QtrA-10780;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Temporal cortex;
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from macaque brain cDNA
RT libraries.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
DR EMBL; AB066544; BAB62218.1; -; mRNA.
DR RefSeq; NP_001306571.1; NM_001319642.1.
DR UniGene; Mfa.8785; -.
DR ProteinModelPortal; Q95K49; -.
DR GeneID; 102146022; -.
DR KEGG; mcf:102146022; -.
DR CTD; 80110; -.
DR HOVERGEN; HBG018163; -.
DR KO; K09228; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 582 Zinc finger protein 614.
FT /FTId=PRO_0000234599.
FT DOMAIN 8 79 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 202 224 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 254 278 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 284 306 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 312 334 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 340 362 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 368 390 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 396 418 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 424 446 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 452 474 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 480 502 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 508 530 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 536 558 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 342 362 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 204 224 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 368 395 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 368 390 ismart:ZnF_C2H2 [T]
FT MYHIT 284 311 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 454 474 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 536 558 ismart:ZnF_C2H2 [T]
FT MYHIT 7 48 ipfam:KRAB [T]
FT MYHIT 536 563 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 538 558 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 8 68 ismart:KRAB [T]
FT MYHIT 8 79 iprf:KRAB [T]
FT MYHIT 482 502 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 340 367 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 202 224 ismart:ZnF_C2H2 [T]
FT MYHIT 370 390 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 510 530 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 286 306 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 508 530 ismart:ZnF_C2H2 [T]
FT MYHIT 312 339 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 284 306 ismart:ZnF_C2H2 [T]
FT MYHIT 340 362 ismart:ZnF_C2H2 [T]
FT MYHIT 312 334 ismart:ZnF_C2H2 [T]
FT MYHIT 480 502 ismart:ZnF_C2H2 [T]
FT MYHIT 424 451 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 452 474 ismart:ZnF_C2H2 [T]
FT MYHIT 426 446 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 424 446 ismart:ZnF_C2H2 [T]
FT MYHIT 398 418 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 202 229 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 508 535 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 314 334 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 480 507 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 396 418 ismart:ZnF_C2H2 [T]
FT MYHIT 396 423 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 452 479 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 582 AA; 66939 MW; DBA59806614C88A6 CRC64;
MIKTQESLTL EDVAVEFSWE EWQLLDTAQK NLYRDVMVEN YNHLVSLGYQ TSKPDVLSKL
AHGQEPWITV AKIQNKNCPG IGKADSLLQE HSLNQRLLKS VQQCNGQNTL RNTVHLSKTH
FPIVQNHDTF DLYRKNLKSS LSLINQKRRH GINNPVEFIG GEKTLKHECM HAKTRFSENA
KCIHTKFQVF KHQRTQKIEK PHACIECEQT FLRKSQLIYH ENIHIPENPG SGQCEKLSRS
VLFTKHLKTN TRDKICIPNE YRKGSTVNSR LIAHQQTHTE EKSYMCSECG KGFTMKRYLI
AHQRTHSGEK PYVCNECGKG FTVKSNLIVH QRTHTGEKPY ICSECGKGFT MKRYLVVHQR
THTGEKPYIC SECGKGFTVK SNLIVHQRSH TGEKSYICSE CGKGFTVKRT LIIHQRTHTG
EKSYICNECG KGFTTKRTLI IHQRTHTGEK PYECNECGKA FSQKICLIQH ERCHTGKTPF
VCTECGKSYS HKYGLITHQR IHTGEKPYEC NECGKAFTTK SVLNVHQRTH TGERPYGCSD
CEKAFSHLSN LVKHKKMHTR EMGRISQVEN SCNEESQLLP YK
//
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