ID ZN614_HUMAN Reviewed; 585 AA.
AC Q8N883; Q494T8; Q8TCF4; Q9BSN8;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 30-NOV-2016, entry version 125.
DE RecName: Full=Zinc finger protein 614;
GN Name=ZNF614;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8IZU0:FAM9B; NbExp=3; IntAct=EBI-9675993, EBI-10175124;
CC Q14938:NFIX; NbExp=3; IntAct=EBI-9675993, EBI-8476987;
CC P14079:tax (xeno); NbExp=3; IntAct=EBI-9675993, EBI-9675698;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N883-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N883-2; Sequence=VSP_056549, VSP_056550;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
DR EMBL; AK097156; BAC04966.1; -; mRNA.
DR EMBL; AC011468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72058.1; -; Genomic_DNA.
DR EMBL; BC004930; AAH04930.1; -; mRNA.
DR EMBL; BC022246; AAH22246.1; -; mRNA.
DR EMBL; BC101392; AAI01393.1; -; mRNA.
DR EMBL; BC101393; AAI01394.1; -; mRNA.
DR EMBL; BC101394; AAI01395.1; -; mRNA.
DR EMBL; BC101395; AAI01396.1; -; mRNA.
DR CCDS; CCDS12847.1; -. [Q8N883-1]
DR RefSeq; NP_079316.2; NM_025040.3. [Q8N883-1]
DR UniGene; Hs.292336; -.
DR ProteinModelPortal; Q8N883; -.
DR SMR; Q8N883; -.
DR BioGrid; 123116; 3.
DR IntAct; Q8N883; 4.
DR STRING; 9606.ENSP00000270649; -.
DR iPTMnet; Q8N883; -.
DR PhosphoSitePlus; Q8N883; -.
DR BioMuta; ZNF614; -.
DR DMDM; 97219309; -.
DR MaxQB; Q8N883; -.
DR PaxDb; Q8N883; -.
DR PeptideAtlas; Q8N883; -.
DR PRIDE; Q8N883; -.
DR Ensembl; ENST00000270649; ENSP00000270649; ENSG00000142556. [Q8N883-1]
DR Ensembl; ENST00000356322; ENSP00000348674; ENSG00000142556. [Q8N883-2]
DR GeneID; 80110; -.
DR KEGG; hsa:80110; -.
DR UCSC; uc002pyi.5; human. [Q8N883-1]
DR CTD; 80110; -.
DR GeneCards; ZNF614; -.
DR HGNC; HGNC:24722; ZNF614.
DR HPA; HPA021197; -.
DR neXtProt; NX_Q8N883; -.
DR OpenTargets; ENSG00000142556; -.
DR PharmGKB; PA134914044; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00860000133760; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8N883; -.
DR KO; K09228; -.
DR OMA; VKHKKMH; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q8N883; -.
DR TreeFam; TF350804; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 80110; -.
DR PRO; PR:Q8N883; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000142556; -.
DR CleanEx; HS_ZNF614; -.
DR ExpressionAtlas; Q8N883; baseline and differential.
DR Genevisible; Q8N883; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 585 Zinc finger protein 614.
FT /FTId=PRO_0000234598.
FT DOMAIN 8 79 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 205 227 C2H2-type 1; atypical.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 257 281 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 287 309 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 315 337 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 343 365 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 371 393 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 399 421 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 427 449 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 455 477 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 483 505 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 511 533 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 539 561 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 161 198 GEKTLLHGKHERTHTKTRFSENAKCIHTKFQVFKHQRT ->
FT ETGSLERPRQADHLRSEVQDQPGQRGETLCLLKIHTKN
FT (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_056549.
FT VAR_SEQ 199 585 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_056550.
FT VARIANT 68 68 T -> I (in dbSNP:rs9636139).
FT /FTId=VAR_052878.
FT VARIANT 160 160 G -> E (in dbSNP:rs45596739).
FT /FTId=VAR_061959.
FT VARIANT 223 223 H -> R (in dbSNP:rs35098634).
FT /FTId=VAR_052879.
FT VARIANT 415 415 V -> I (in dbSNP:rs8104890).
FT /FTId=VAR_052880.
FT CONFLICT 250 250 L -> P (in Ref. 1; BAC04966).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 289 309 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 7 48 ipfam:KRAB [T]
FT MYHIT 401 421 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 205 225 ismart:ZnF_C2H2 [T]
FT MYHIT 315 337 ismart:ZnF_C2H2 [T]
FT MYHIT 455 477 ismart:ZnF_C2H2 [T]
FT MYHIT 427 449 ismart:ZnF_C2H2 [T]
FT MYHIT 429 449 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 287 314 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 457 477 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 345 365 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 317 337 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 455 482 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 315 342 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 539 566 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 427 454 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 373 393 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 371 393 ismart:ZnF_C2H2 [T]
FT MYHIT 8 68 ismart:KRAB [T]
FT MYHIT 541 561 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 287 309 ismart:ZnF_C2H2 [T]
FT MYHIT 399 426 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 343 365 ismart:ZnF_C2H2 [T]
FT MYHIT 371 398 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 343 370 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 539 561 ismart:ZnF_C2H2 [T]
FT MYHIT 511 538 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 8 79 iprf:KRAB [T]
FT MYHIT 483 510 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 513 533 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 205 232 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 483 505 ismart:ZnF_C2H2 [T]
FT MYHIT 511 533 ismart:ZnF_C2H2 [T]
FT MYHIT 485 505 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 399 421 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 585 AA; 67215 MW; 761FFD8B035CDAA4 CRC64;
MIKTQESLTL EDVAVEFSWE EWQLLDTAQK NLYRDVMVEN YNHLVSLGYQ TSKPDVLSKL
AHGQEPWTTD AKIQNKNCPG IGKVDSHLQE HSPNQRLLKS VQQCNGQNTL RNIVHLSKTH
FPIVQNHDTF DLYRKNLKSS LSLINQKRRH GINNPVEFIG GEKTLLHGKH ERTHTKTRFS
ENAKCIHTKF QVFKHQRTQK IEKPHACIEC EQTFLRKSQL IYHENICIQE NPGSGQCEKL
SRSVLFTKHL KTNTTDKICI PNEYRKGSTV KSSLITHQQT HTEEKSYMCS ECGKGFTMKR
YLIAHQRTHS GEKPYVCKEC GKGFTVKSNL IVHQRTHTGE KPYICSECGK GFTMKRYLVV
HQRTHTGEKP YMCSECGKGF TVKSNLIVHQ RSHTGEKSYI CSECGKGFTV KRTLVIHQRT
HTGEKSYICN ECGKGFTTKR TLIIHQRTHT GEKPYECNEC GKAFSQKICL IQHERCHTGK
TPFVCTECGK SYSHKYGLIT HQRIHTGEKP YECNECGKAF TTKSVLNVHQ RTHTGERPYG
CSDCEKAFSH LSNLVKHKKM HTREMGRISQ VENSCNGESQ LLPYK
//
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