Legends: 1, Phosphoserine. {ECO:0000250|UniProtKB:Q6ZN55}; 2, Phosphothreonine. {ECO:0000250|UniProtKB:Q6ZN55}; 3, Asymmetric dimethylarginine. {ECO:0000250|UniProtKB:Q6ZN55}; 4, ZN_FING C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 15, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 16, ZN_FING C2H2-type 13. {ECO:0000255|PROSITE- ProRule:PRU00042}; 17, ZN_FING C2H2-type 14. {ECO:0000255|PROSITE- ProRule:PRU00042}; 18, ZN_FING C2H2-type 15; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 19, ZN_FING C2H2-type 16. {ECO:0000255|PROSITE- ProRule:PRU00042}; 20, ZN_FING C2H2-type 17. {ECO:0000255|PROSITE- ProRule:PRU00042}; 21, ZN_FING C2H2-type 18. {ECO:0000255|PROSITE- ProRule:PRU00042}; 22, ZN_FING C2H2-type 19. {ECO:0000255|PROSITE- ProRule:PRU00042}; 23, ZN_FING C2H2-type 20. {ECO:0000255|PROSITE- ProRule:PRU00042}; 24, COMPBIAS Pro-rich; 25, COMPBIAS Ala-rich; 26, ipat:ZINC_FINGER_C2H2_1 [T]; 27, ismart:ZnF_C2H2 [T]; 28, iprf:ZINC_FINGER_C2H2_2 [T].
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ID ZN574_PONAB Reviewed; 895 AA.
AC Q5R4P8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 30-NOV-2016, entry version 74.
DE RecName: Full=Zinc finger protein 574;
GN Name=ZNF574;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 20 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR EMBL; CR861197; CAH93268.1; -; mRNA.
DR RefSeq; NP_001126922.1; NM_001133450.1.
DR UniGene; Pab.1555; -.
DR ProteinModelPortal; Q5R4P8; -.
DR STRING; 9601.ENSPPYP00000011231; -.
DR GeneID; 100173939; -.
DR KEGG; pon:100173939; -.
DR CTD; 64763; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR HOVERGEN; HBG103121; -.
DR InParanoid; Q5R4P8; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 11.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM00355; ZnF_C2H2; 20.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Methylation; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 895 Zinc finger protein 574.
FT /FTId=PRO_0000274864.
FT ZN_FING 16 38 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 76 98 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 126 148 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 214 236 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 309 331 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 336 358 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 364 386 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 392 413 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 466 489 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 495 517 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 523 545 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 551 573 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 579 601 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 607 630 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 636 659 C2H2-type 15; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 667 689 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 737 759 C2H2-type 17. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 765 787 C2H2-type 18. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 793 815 C2H2-type 19. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 821 843 C2H2-type 20. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT COMPBIAS 419 451 Pro-rich.
FT COMPBIAS 657 732 Ala-rich.
FT MOD_RES 164 164 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 298 298 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 717 717 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 724 724 Phosphothreonine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 728 728 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 831 831 Asymmetric dimethylarginine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 78 98 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 495 517 ismart:ZnF_C2H2 [T]
FT MYHIT 737 759 ismart:ZnF_C2H2 [T]
FT MYHIT 76 98 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 523 550 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 497 517 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 392 413 ismart:ZnF_C2H2 [T]
FT MYHIT 128 148 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 607 635 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 581 601 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 579 606 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 126 153 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 823 843 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 338 358 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 667 689 ismart:ZnF_C2H2 [T]
FT MYHIT 821 843 ismart:ZnF_C2H2 [T]
FT MYHIT 76 98 ismart:ZnF_C2H2 [T]
FT MYHIT 765 792 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 466 489 ismart:ZnF_C2H2 [T]
FT MYHIT 468 489 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 765 787 ismart:ZnF_C2H2 [T]
FT MYHIT 16 38 ismart:ZnF_C2H2 [T]
FT MYHIT 795 815 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 16 43 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 767 787 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 495 522 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 309 331 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 737 764 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 364 387 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 126 148 ismart:ZnF_C2H2 [T]
FT MYHIT 669 689 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 579 601 ismart:ZnF_C2H2 [T]
FT MYHIT 607 630 ismart:ZnF_C2H2 [T]
FT MYHIT 216 236 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 739 759 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 311 331 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 821 848 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 309 331 ismart:ZnF_C2H2 [T]
FT MYHIT 336 363 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 18 38 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 551 578 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 336 358 ismart:ZnF_C2H2 [T]
FT MYHIT 636 656 ismart:ZnF_C2H2 [T]
FT MYHIT 366 386 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 214 236 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 793 820 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 525 545 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 609 630 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 551 573 ismart:ZnF_C2H2 [T]
FT MYHIT 523 545 ismart:ZnF_C2H2 [T]
FT MYHIT 553 573 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 636 664 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 466 494 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 214 236 ismart:ZnF_C2H2 [T]
FT MYHIT 364 386 ismart:ZnF_C2H2 [T]
FT MYHIT 793 815 ismart:ZnF_C2H2 [T]
FT MYHIT 667 694 iprf:ZINC_FINGER_C2H2_2 [T]
SQ SEQUENCE 895 AA; 98809 MW; FE5A09ABEA5ADF83 CRC64;
MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLMHQNSHVP QQHFELVGVA DPGVTVATDT
ASGTGLYQTL VQESQYQCLE CGQLLMSPSQ LLEHQELHLK MMAPQEAVPA EPPPKAPPLS
SSTIHYECVD CKALFASQEL WLNHRQTHLR ATPTKAPAPV VLGSPVVLGP PVGQARVAVE
HSYRKAEEGG EGATVPSAAA TTTEVVTEVE LLLYKCSECS QLFQLPADFL EHQATHFPAP
VPESQEPALQ QEVQASSPAE VPVSQPDPLP ASDHSYELRN GEAIGRDRRG RRARRNNSGE
AGGAATQELF CSACDQLFLS PHQLQQHLRS HREGVFKCPL CSRVFPSPSS LDQHLGDHSS
ESHFLCVDCG LAFGTEALLL AHRRAHTPNP LHSCPCGKTF VNLTKFLYHR RTHGVGGVPL
PTTPVPPEEP VIGFPEPAPA ETGEPEAPEP PVSEETSAGP AAPGTYRCLL CSREFGKALQ
LTRHQRFVHR LERRHKCSIC GKMFKKKSHV RNHLRTHTGE RPFPCPDCSK PFNSPANLAR
HRLTHTGERP YRCGDCGKAF TQSSTLRQHR LVHAQHFPYR CQECGVRFHR PYRLLMHRYH
HTGEYPYKCR ECPRSFLLRR LLEVHQLVVH AGRQPHRCPS CGAAFPSSLR LREHRCAAAA
AQAPRRFECG TCGKKVGSAA RLQAHEAAHA AAGPGEVLAK EPPAPRAPRA TRAPVASPAA
LGGTATASPA PARRRGLECS ECKKLFSTET SLQVHRRIHT GERPYPCPDC GKAFRQSTHL
KDHRRLHTGE RPFACEVCGK AFAISMRLAE HRRIHTGERP YSCPDCGKSY RSFSNLWKHR
KTHQQQHQAA VRQQLAEAEA AVGLAVMETA VEALPLVEAI EIYPLAEAEG VQISG
//
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