Legends: 1, Phosphoserine. {ECO:0000250|UniProtKB:Q6ZN55}; 2, Phosphothreonine. {ECO:0000250|UniProtKB:Q6ZN55}; 3, Asymmetric dimethylarginine. {ECO:0000250|UniProtKB:Q6ZN55}; 4, ZN_FING C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 15, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 16, ZN_FING C2H2-type 13. {ECO:0000255|PROSITE- ProRule:PRU00042}; 17, ZN_FING C2H2-type 14. {ECO:0000255|PROSITE- ProRule:PRU00042}; 18, ZN_FING C2H2-type 15; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 19, ZN_FING C2H2-type 16. {ECO:0000255|PROSITE- ProRule:PRU00042}; 20, ZN_FING C2H2-type 17. {ECO:0000255|PROSITE- ProRule:PRU00042}; 21, ZN_FING C2H2-type 18. {ECO:0000255|PROSITE- ProRule:PRU00042}; 22, ZN_FING C2H2-type 19. {ECO:0000255|PROSITE- ProRule:PRU00042}; 23, ZN_FING C2H2-type 20. {ECO:0000255|PROSITE- ProRule:PRU00042}; 24, COMPBIAS Pro-rich; 25, COMPBIAS Ala-rich; 26, ipat:ZINC_FINGER_C2H2_1 [T]; 27, iprf:ZINC_FINGER_C2H2_2 [T]; 28, ismart:ZnF_C2H2 [T].
|
ID ZN574_MACFA Reviewed; 896 AA.
AC Q4R8S8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 30-NOV-2016, entry version 70.
DE RecName: Full=Zinc finger protein 574;
GN Name=ZNF574; ORFNames=QtsA-11557;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-896.
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 20 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE00493.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR EMBL; AB168370; BAE00493.1; ALT_INIT; mRNA.
DR RefSeq; NP_001270061.1; NM_001283132.1.
DR UniGene; Mfa.8816; -.
DR ProteinModelPortal; Q4R8S8; -.
DR PRIDE; Q4R8S8; -.
DR GeneID; 101865225; -.
DR KEGG; mcf:101865225; -.
DR CTD; 64763; -.
DR HOVERGEN; HBG103121; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 11.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM00355; ZnF_C2H2; 20.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Methylation; Nucleus; Phosphoprotein;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 896 Zinc finger protein 574.
FT /FTId=PRO_0000274862.
FT ZN_FING 16 38 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 76 98 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 126 148 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 214 236 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 309 331 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 336 358 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 364 386 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 392 413 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 466 489 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 495 517 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 523 545 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 551 573 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 579 601 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 607 630 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 636 659 C2H2-type 15; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 667 689 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 738 760 C2H2-type 17. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 766 788 C2H2-type 18. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 794 816 C2H2-type 19. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 822 844 C2H2-type 20. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT COMPBIAS 419 451 Pro-rich.
FT COMPBIAS 625 701 Ala-rich.
FT COMPBIAS 657 733 Ala-rich.
FT MOD_RES 164 164 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 298 298 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 717 717 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 724 724 Phosphothreonine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 728 728 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 832 832 Asymmetric dimethylarginine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 740 760 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 468 489 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 824 844 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 551 578 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 466 489 ismart:ZnF_C2H2 [T]
FT MYHIT 794 816 ismart:ZnF_C2H2 [T]
FT MYHIT 366 386 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 18 38 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 579 601 ismart:ZnF_C2H2 [T]
FT MYHIT 738 765 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 768 788 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 667 694 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 607 630 ismart:ZnF_C2H2 [T]
FT MYHIT 495 522 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 553 573 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 76 98 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 523 545 ismart:ZnF_C2H2 [T]
FT MYHIT 579 606 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 523 550 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 766 793 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 311 331 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 128 148 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 16 38 ismart:ZnF_C2H2 [T]
FT MYHIT 581 601 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 525 545 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 607 635 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 336 358 ismart:ZnF_C2H2 [T]
FT MYHIT 216 236 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 636 656 ismart:ZnF_C2H2 [T]
FT MYHIT 794 821 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 336 363 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 392 413 ismart:ZnF_C2H2 [T]
FT MYHIT 76 98 ismart:ZnF_C2H2 [T]
FT MYHIT 667 689 ismart:ZnF_C2H2 [T]
FT MYHIT 309 331 ismart:ZnF_C2H2 [T]
FT MYHIT 364 387 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 822 849 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 551 573 ismart:ZnF_C2H2 [T]
FT MYHIT 214 236 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 78 98 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 126 148 ismart:ZnF_C2H2 [T]
FT MYHIT 766 788 ismart:ZnF_C2H2 [T]
FT MYHIT 126 153 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 466 494 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 364 386 ismart:ZnF_C2H2 [T]
FT MYHIT 214 236 ismart:ZnF_C2H2 [T]
FT MYHIT 738 760 ismart:ZnF_C2H2 [T]
FT MYHIT 309 331 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 495 517 ismart:ZnF_C2H2 [T]
FT MYHIT 497 517 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 669 689 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 636 664 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 338 358 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 822 844 ismart:ZnF_C2H2 [T]
FT MYHIT 16 43 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 609 630 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 796 816 ipat:ZINC_FINGER_C2H2_1 [T]
SQ SEQUENCE 896 AA; 98866 MW; A5ECBFB948C25469 CRC64;
MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLMHQNSHVP QQHFELVGVA DPGVTVATDT
ASGTGLYQTL VQESQYQCLE CGQLLMSPSQ LLEHQELHLK MMTPQEAVPA EPPPKAPPLS
SSTIHYECVD CKALFASQEL WLNHRQTHLR ATPTKAPAPV VLGSPVVPGP PVGQARVAVE
HSYRKAEEGG EGATVPSAAA TTTEVVTEVE LLLYKCSECS QLFQLPADFL EHQATHFPAP
VPESQEPALQ QEVQASSPAE VPVSQPDPVP ASDHSYELRN GEAIGRDRRG RRARRNNSGE
AGGAATQELF CSACDQLFLS PHQLQQHLRS HREGVFKCPL CSRVFPSPSS LDQHLGDHSS
ESHFLCVDCG LAFGTEALLL AHRRAHTPNP LHSCPCGKTF VNLTKFLYHR RTHGVGGVPL
PTTPVPPEEP VIGFPEPAPA ETGEPEAPEP PVSEETSAGP AAPGTYRCLL CSREFGKALQ
LTRHQRFVHR LERRHKCSIC GKMFKKKSHV RNHLRTHTGE RPFPCPDCSK PFNSPANLAR
HRLTHTGERP YRCGDCGKAF TQSSTLRQHR LVHAQHFPYR CQECGVRFHR PYRLLMHRYH
HTGEYPYKCR ECPRSFLLRR LLEVHQLVVH AGRQPHRCPS CGAAFPSSLR LREHRCAAAA
AQAPRRFECG TCGKKVGSAA RLQAHEAAHA AAGPGEVLAK EPPAPRAPRA TRAPVASPAG
LGGTATASPA APARRRGLEC SECKKLFSTE TSLQVHRRIH TGERPYPCPD CGKAFRQSTH
LKDHRRLHTG ERPFACEVCG KAFAISMRLA EHRRIHTGER PYSCPDCGKS YRSFSNLWKH
RKTHQQQHQA AVRQQLAEAE AAVGLAVMET AVEALPLVEA IEIYPLAEAE GVQISG
//
|
