Legends: 1, Phosphoserine. {ECO:0000250|UniProtKB:Q6ZN55}; 2, Asymmetric dimethylarginine. {ECO:0000250|UniProtKB:Q6ZN55}; 3, ZN_FING C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042}; 4, ZN_FING C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 15, ZN_FING C2H2-type 13. {ECO:0000255|PROSITE- ProRule:PRU00042}; 16, ZN_FING C2H2-type 14. {ECO:0000255|PROSITE- ProRule:PRU00042}; 17, ZN_FING C2H2-type 15; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 18, ZN_FING C2H2-type 16. {ECO:0000255|PROSITE- ProRule:PRU00042}; 19, ZN_FING C2H2-type 17. {ECO:0000255|PROSITE- ProRule:PRU00042}; 20, ZN_FING C2H2-type 18. {ECO:0000255|PROSITE- ProRule:PRU00042}; 21, ZN_FING C2H2-type 19. {ECO:0000255|PROSITE- ProRule:PRU00042}; 22, ZN_FING C2H2-type 20. {ECO:0000255|PROSITE- ProRule:PRU00042}; 23, COMPBIAS Pro-rich; 24, COMPBIAS Ala-rich; 25, ipat:ZINC_FINGER_C2H2_1 [T]; 26, iprf:ZINC_FINGER_C2H2_2 [T]; 27, ismart:ZnF_C2H2 [T].
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ID ZN574_BOVIN Reviewed; 896 AA.
AC Q29RK0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 30-NOV-2016, entry version 74.
DE RecName: Full=Zinc finger protein 574;
GN Name=ZNF574;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 20 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR EMBL; BC114139; AAI14140.1; -; mRNA.
DR RefSeq; NP_001070007.1; NM_001076539.1.
DR UniGene; Bt.2661; -.
DR ProteinModelPortal; Q29RK0; -.
DR STRING; 9913.ENSBTAP00000047002; -.
DR PaxDb; Q29RK0; -.
DR PRIDE; Q29RK0; -.
DR GeneID; 767618; -.
DR KEGG; bta:767618; -.
DR CTD; 64763; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR HOGENOM; HOG000065747; -.
DR HOVERGEN; HBG103121; -.
DR InParanoid; Q29RK0; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 11.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM00355; ZnF_C2H2; 20.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Methylation; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 896 Zinc finger protein 574.
FT /FTId=PRO_0000274860.
FT ZN_FING 16 38 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 76 98 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 126 148 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 214 236 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 309 331 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 336 358 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 364 386 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 392 413 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 466 489 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 495 517 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 523 545 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 551 573 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 579 601 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 607 630 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 636 659 C2H2-type 15; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 667 689 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 738 760 C2H2-type 17. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 766 788 C2H2-type 18. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 794 816 C2H2-type 19. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 822 844 C2H2-type 20. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT COMPBIAS 419 451 Pro-rich.
FT COMPBIAS 657 733 Ala-rich.
FT MOD_RES 164 164 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 298 298 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 717 717 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
FT MOD_RES 832 832 Asymmetric dimethylarginine.
FT {ECO:0000250|UniProtKB:Q6ZN55}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 497 517 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 667 694 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 607 630 ismart:ZnF_C2H2 [T]
FT MYHIT 16 38 ismart:ZnF_C2H2 [T]
FT MYHIT 523 545 ismart:ZnF_C2H2 [T]
FT MYHIT 523 550 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 466 489 ismart:ZnF_C2H2 [T]
FT MYHIT 525 545 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 768 788 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 76 98 ismart:ZnF_C2H2 [T]
FT MYHIT 636 664 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 609 630 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 466 494 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 338 358 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 311 331 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 669 689 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 76 98 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 822 844 ismart:ZnF_C2H2 [T]
FT MYHIT 214 236 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 738 760 ismart:ZnF_C2H2 [T]
FT MYHIT 366 386 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 126 148 ismart:ZnF_C2H2 [T]
FT MYHIT 553 573 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 636 656 ismart:ZnF_C2H2 [T]
FT MYHIT 551 578 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 364 387 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 822 849 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 794 816 ismart:ZnF_C2H2 [T]
FT MYHIT 214 236 ismart:ZnF_C2H2 [T]
FT MYHIT 336 358 ismart:ZnF_C2H2 [T]
FT MYHIT 336 363 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 607 635 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 78 98 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 551 573 ismart:ZnF_C2H2 [T]
FT MYHIT 16 43 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 126 153 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 495 517 ismart:ZnF_C2H2 [T]
FT MYHIT 579 601 ismart:ZnF_C2H2 [T]
FT MYHIT 581 601 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 495 522 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 667 689 ismart:ZnF_C2H2 [T]
FT MYHIT 766 793 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 824 844 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 216 236 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 128 148 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 579 606 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 309 331 ismart:ZnF_C2H2 [T]
FT MYHIT 18 38 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 796 816 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 794 821 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 468 489 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 738 765 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 766 788 ismart:ZnF_C2H2 [T]
FT MYHIT 309 331 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 392 413 ismart:ZnF_C2H2 [T]
FT MYHIT 740 760 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 364 386 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 896 AA; 99010 MW; 638621A80D398E78 CRC64;
MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLMHQNSHVP QQHFELVGVA DPGVTVAAEA
ASGTGLYQTL VQESQYQCLE CGQLLMSPSQ LLEHQELHLK MMAPQEAVPA EPPPKAPALS
SSTIHYECVD CKALFASQEL WLNHRQTHLR ATPTKPPTPV VLGSPVVVGS PVGQTRVAVE
HSYRKAEEGG EGAAVPSAAA TTTEVVTEVE LLLYKCSECS QLFQLPADFL EHQATHFPAP
APESEEPVLQ QETLTPAPVE VPVSQPEPVP SSDHSYELRN GEALGRDRRG RRARRNNSGE
PGGAATQELF CSACDQLFLS PHQLQQHLRS HREGVFKCPL CSRVFPSPSS LDQHLGDHSS
ESHFLCVDCG LAFGTEALLL AHRRAHTPNP LHSCPCGKTF VNLTKFLYHR RTHGVGGVPL
PTTPVPPEEP VLGFPEPAPA ETGEPEAPEP PVAEESSAEP AAPGTYRCLL CSREFGKALQ
LTRHQRFVHR LERRHKCSIC GKMFKKKSHV RNHLRTHTGE RPFPCPDCSK PFNSPANLAR
HRLTHTGERP YRCGDCGKAF TQSSTLRQHR LVHAQHFPYR CQECGVRFHR PYRLLMHRYH
HTGEYPYKCR ECPRSFLLRR LLEVHQLVAH AGRQPHRCSS CGAAFPSSLR LREHRCAAAA
AQAPRRFECG TCGKKVGSAA RLQAHEAAHA AAGPGEVLAK EPPAPRAPRA ARTPITSPTT
LGSAAPAAPA APARRRGLEC SECKKLFSTE TSLQVHRRIH TGERPYPCPD CGKAFRQSTH
LKDHRRLHTG ERPFACEVCG KAFAISMRLA EHRRIHTGER PYSCPDCGKS YRSFSNLWKH
RKTHQQQHQA AVRQQLAEAE AAVGLAVMET AVEALPLVEA IEIYPLAEAE GVQISG
//
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