Entry sw:ZN570_HUMAN

ID   ZN570_HUMAN             Reviewed;         536 AA.
AC   Q96NI8; A1L472; B4DMP1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   02-NOV-2016, entry version 121.
DE   RecName: Full=Zinc finger protein 570;
GN   Name=ZNF570;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96NI8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96NI8-2; Sequence=VSP_055967;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 11 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC   -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00119}.
DR   EMBL; AK055353; BAB70908.1; -; mRNA.
DR   EMBL; AK297561; BAG59953.1; -; mRNA.
DR   EMBL; AC008806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471126; EAW56732.1; -; Genomic_DNA.
DR   EMBL; BC130425; AAI30426.1; -; mRNA.
DR   EMBL; BC130433; AAI30434.1; -; mRNA.
DR   CCDS; CCDS12504.1; -. [Q96NI8-1]
DR   RefSeq; NP_001308920.1; NM_001321991.1. [Q96NI8-1]
DR   RefSeq; NP_001308921.1; NM_001321992.1.
DR   RefSeq; NP_001308922.1; NM_001321993.1. [Q96NI8-2]
DR   RefSeq; NP_001308923.1; NM_001321994.1. [Q96NI8-2]
DR   RefSeq; NP_653295.1; NM_144694.3. [Q96NI8-1]
DR   RefSeq; XP_011524846.1; XM_011526544.2. [Q96NI8-1]
DR   UniGene; Hs.126962; -.
DR   UniGene; Hs.350875; -.
DR   UniGene; Hs.714241; -.
DR   ProteinModelPortal; Q96NI8; -.
DR   SMR; Q96NI8; -.
DR   STRING; 9606.ENSP00000331540; -.
DR   iPTMnet; Q96NI8; -.
DR   PhosphoSitePlus; Q96NI8; -.
DR   BioMuta; ZNF570; -.
DR   DMDM; 74762681; -.
DR   PaxDb; Q96NI8; -.
DR   PeptideAtlas; Q96NI8; -.
DR   PRIDE; Q96NI8; -.
DR   Ensembl; ENST00000330173; ENSP00000331540; ENSG00000171827. [Q96NI8-1]
DR   GeneID; 148268; -.
DR   KEGG; hsa:148268; -.
DR   UCSC; uc002ogk.2; human. [Q96NI8-1]
DR   CTD; 148268; -.
DR   GeneCards; ZNF570; -.
DR   HGNC; HGNC:26416; ZNF570.
DR   HPA; HPA028881; -.
DR   neXtProt; NX_Q96NI8; -.
DR   OpenTargets; ENSG00000171827; -.
DR   PharmGKB; PA134943423; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00840000129704; -.
DR   HOGENOM; HOG000234617; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q96NI8; -.
DR   KO; K09228; -.
DR   PhylomeDB; Q96NI8; -.
DR   TreeFam; TF341817; -.
DR   BioCyc; ZFISH:ENSG00000161322-MONOMER; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   GenomeRNAi; 148268; -.
DR   PRO; PR:Q96NI8; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000171827; -.
DR   CleanEx; HS_ZNF570; -.
DR   ExpressionAtlas; Q96NI8; baseline and differential.
DR   Genevisible; Q96NI8; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 3.30.160.60; -; 11.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   Pfam; PF13912; zf-C2H2_6; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    536       Zinc finger protein 570.
FT                                /FTId=PRO_0000047661.
FT   DOMAIN       14     85       KRAB. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00119}.
FT   ZN_FING     218    240       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     246    268       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     274    296       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     302    324       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     330    352       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     358    380       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     386    408       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     414    436       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     442    464       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     470    492       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     498    520       C2H2-type 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   VAR_SEQ       1    203       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_055967.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       330    352       ismart:ZnF_C2H2 [T]
FT   MYHIT       500    520       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT        14     74       ismart:KRAB [T]
FT   MYHIT       414    441       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       332    352       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       416    436       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       218    245       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       498    520       ismart:ZnF_C2H2 [T]
FT   MYHIT       470    497       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       498    525       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       220    240       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       472    492       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT        14     85       iprf:KRAB [T]
FT   MYHIT       304    324       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       470    492       ismart:ZnF_C2H2 [T]
FT   MYHIT        13     54       ipfam:KRAB [T]
FT   MYHIT       330    357       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       442    464       ismart:ZnF_C2H2 [T]
FT   MYHIT       386    408       ismart:ZnF_C2H2 [T]
FT   MYHIT       442    469       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       276    296       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       274    296       ismart:ZnF_C2H2 [T]
FT   MYHIT       302    324       ismart:ZnF_C2H2 [T]
FT   MYHIT       218    240       ismart:ZnF_C2H2 [T]
FT   MYHIT       444    464       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       246    268       ismart:ZnF_C2H2 [T]
FT   MYHIT       358    380       ismart:ZnF_C2H2 [T]
FT   MYHIT       414    436       ismart:ZnF_C2H2 [T]
FT   MYHIT       248    268       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       360    380       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       302    329       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       246    273       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       358    385       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       388    408       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       386    413       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       274    301       iprf:ZINC_FINGER_C2H2_2 [T]
SQ   SEQUENCE   536 AA;  62330 MW;  C3DD6CEE42C953EB CRC64;
     MAVGLLKAMY QELVTFRDVA VDFSQEEWDC LDSSQRHLYS NVMLENYRIL VSLGLCFSKP
     SVILLLEQGK APWMVKRELT KGLCSGWEPI CETEELTPKQ DFYEEHQSQK IIETLTSYNL
     EYSSLREEWK CEGYFERQPG NQKACFKEEI ITHEEPLFDE REQEYKSWGS FHQNPLLCTQ
     KIIPKEEKVH KHDTQKRSFK KNLMAIKPKS VCAEKKLLKC NDCEKVFSQS SSLTLHQRIH
     TGEKPYKCIE CGKAFSQRSN LVQHQRIHTG EKPYECKECR KAFSQNAHLV QHLRVHTGEK
     PYECKVCRKA FSQFAYLAQH QRVHTGEKPY ECIECGKAFS NRSSIAQHQR VHTGEKPYEC
     NVCGKAFSLR AYLTVHQRIH TGERPYECKE CGKAFSQNSH LAQHQRIHTG EKPYKCQECR
     KAFSQIAYLA QHQRVHTGEK PYECIECGKA FSNDSSLTQH QRVHTGEKPY ECTVCGKAFS
     YCGSLAQHQR IHTGERPYEC KECKKTFRQH AHLAHHQRIH IGESLSPPNP VNHQVL
//