ID ZN564_HUMAN Reviewed; 553 AA.
AC Q8TBZ8; B9EGT4; Q6P1K6;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 30-NOV-2016, entry version 127.
DE RecName: Full=Zinc finger protein 564;
GN Name=ZNF564;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-438, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447; DOI=10.1038/nsmb.2890;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P13196:ALAS1; NbExp=5; IntAct=EBI-10273713, EBI-3905054;
CC Q13137:CALCOCO2; NbExp=3; IntAct=EBI-10273713, EBI-739580;
CC Q96JN2-2:CCDC136; NbExp=3; IntAct=EBI-10273713, EBI-10171416;
CC Q15834:CCDC85B; NbExp=3; IntAct=EBI-10273713, EBI-739674;
CC O95273:CCNDBP1; NbExp=3; IntAct=EBI-10273713, EBI-748961;
CC Q9HD26:GOPC; NbExp=3; IntAct=EBI-10273713, EBI-349832;
CC Q6A162:KRT40; NbExp=3; IntAct=EBI-10273713, EBI-10171697;
CC P60409:KRTAP10-7; NbExp=3; IntAct=EBI-10273713, EBI-10172290;
CC P60411:KRTAP10-9; NbExp=3; IntAct=EBI-10273713, EBI-10172052;
CC O95751:LDOC1; NbExp=3; IntAct=EBI-10273713, EBI-740738;
CC P43355:MAGEA1; NbExp=3; IntAct=EBI-10273713, EBI-740978;
CC Q99750:MDFI; NbExp=5; IntAct=EBI-10273713, EBI-724076;
CC A4D127:MEOX2; NbExp=3; IntAct=EBI-10273713, EBI-10172134;
CC Q9UJV3-2:MID2; NbExp=5; IntAct=EBI-10273713, EBI-10172526;
CC Q8ND90:PNMA1; NbExp=3; IntAct=EBI-10273713, EBI-302345;
CC Q04864:REL; NbExp=3; IntAct=EBI-10273713, EBI-307352;
CC Q96KN7:RPGRIP1; NbExp=3; IntAct=EBI-10273713, EBI-1050213;
CC Q8NA61:SPERT; NbExp=3; IntAct=EBI-10273713, EBI-741724;
CC O75478:TADA2A; NbExp=3; IntAct=EBI-10273713, EBI-742268;
CC Q13077:TRAF1; NbExp=5; IntAct=EBI-10273713, EBI-359224;
CC P36406:TRIM23; NbExp=5; IntAct=EBI-10273713, EBI-740098;
CC Q8WV44:TRIM41; NbExp=3; IntAct=EBI-10273713, EBI-725997;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 15 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28367.2; Type=Erroneous initiation; Evidence={ECO:0000305};
DR EMBL; AK092760; BAC03967.1; -; mRNA.
DR EMBL; BC028367; AAH28367.2; ALT_INIT; mRNA.
DR EMBL; BC065023; AAH65023.2; -; mRNA.
DR EMBL; BC136728; AAI36729.1; -; mRNA.
DR EMBL; BC136729; AAI36730.1; -; mRNA.
DR CCDS; CCDS42505.1; -.
DR RefSeq; NP_659413.1; NM_144976.3.
DR UniGene; Hs.655615; -.
DR ProteinModelPortal; Q8TBZ8; -.
DR SMR; Q8TBZ8; -.
DR BioGrid; 127844; 25.
DR IntAct; Q8TBZ8; 29.
DR STRING; 9606.ENSP00000340004; -.
DR iPTMnet; Q8TBZ8; -.
DR PhosphoSitePlus; Q8TBZ8; -.
DR BioMuta; ZNF564; -.
DR DMDM; 55976746; -.
DR EPD; Q8TBZ8; -.
DR MaxQB; Q8TBZ8; -.
DR PaxDb; Q8TBZ8; -.
DR PeptideAtlas; Q8TBZ8; -.
DR PRIDE; Q8TBZ8; -.
DR Ensembl; ENST00000339282; ENSP00000340004; ENSG00000249709.
DR GeneID; 163050; -.
DR KEGG; hsa:163050; -.
DR UCSC; uc002mty.4; human.
DR CTD; 163050; -.
DR GeneCards; ZNF564; -.
DR HGNC; HGNC:31106; ZNF564.
DR HPA; HPA043998; -.
DR neXtProt; NX_Q8TBZ8; -.
DR OpenTargets; ENSG00000249709; -.
DR PharmGKB; PA134876070; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119089; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8TBZ8; -.
DR KO; K09228; -.
DR OMA; KRIRKHM; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q8TBZ8; -.
DR TreeFam; TF338854; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 163050; -.
DR PRO; PR:Q8TBZ8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000249709; -.
DR CleanEx; HS_ZNF564; -.
DR ExpressionAtlas; Q8TBZ8; baseline and differential.
DR Genevisible; Q8TBZ8; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0044212; F:transcription regulatory region DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 15.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13912; zf-C2H2_6; 4.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW Complete proteome; DNA-binding; Isopeptide bond; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1 553 Zinc finger protein 564.
FT /FTId=PRO_0000047654.
FT DOMAIN 4 83 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 103 125 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 141 163 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 169 191 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 197 219 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 225 247 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 253 275 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 281 303 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 309 331 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 337 359 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 365 387 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 393 415 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 421 443 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 449 471 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 477 499 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 505 527 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT CROSSLNK 438 438 Glycyl lysine isopeptide (Lys-Gly)
FT (interchain with G-Cter in SUMO2).
FT {ECO:0000244|PubMed:25218447}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 393 415 ismart:ZnF_C2H2 [T]
FT MYHIT 227 247 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 169 191 ismart:ZnF_C2H2 [T]
FT MYHIT 141 163 ismart:ZnF_C2H2 [T]
FT MYHIT 253 275 ismart:ZnF_C2H2 [T]
FT MYHIT 477 499 ismart:ZnF_C2H2 [T]
FT MYHIT 339 359 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 4 83 iprf:KRAB [T]
FT MYHIT 3 44 ipfam:KRAB [T]
FT MYHIT 423 443 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 143 163 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 253 280 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 505 527 ismart:ZnF_C2H2 [T]
FT MYHIT 507 527 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 225 247 ismart:ZnF_C2H2 [T]
FT MYHIT 171 191 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 281 308 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 479 499 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 449 476 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 367 387 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 449 471 ismart:ZnF_C2H2 [T]
FT MYHIT 103 125 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 311 331 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 309 331 ismart:ZnF_C2H2 [T]
FT MYHIT 421 443 ismart:ZnF_C2H2 [T]
FT MYHIT 225 252 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 477 504 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 199 219 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 281 303 ismart:ZnF_C2H2 [T]
FT MYHIT 169 196 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 141 168 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 283 303 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 365 392 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 309 336 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 395 415 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 337 364 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 103 130 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 103 125 ismart:ZnF_C2H2 [T]
FT MYHIT 197 219 ismart:ZnF_C2H2 [T]
FT MYHIT 4 56 ismart:KRAB [T]
FT MYHIT 337 359 ismart:ZnF_C2H2 [T]
FT MYHIT 505 532 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 197 224 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 421 448 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 393 420 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 451 471 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 255 275 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 365 387 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 553 AA; 63735 MW; CE5DB6E5D47EE019 CRC64;
MDSVASEDVA VNFTLEEWAL LDPSQKKLYR DVMRETFRNL ACVGKKWEDQ SIEDWYKNQG
RILRNHMEEG LSESKEYDQC GEAFSQILNL NLNKKIPTIV RPCECSLCGK VFMHHSSLSR
HIRSHLGHKP YDYQEYGEKP YKCKQCGKAF SSCQSFRRHE RTHTGEKPYA CPECGKAFIS
LPSVRRHMIK HTGDGPYKCQ ECGKAFDRPS LFQIHERTHT GEKPYECQEC AKAFISLPSF
QRHMIRHTGD GPYKCQECGK AFDRPSLFRI HERTHTGEKP HECKQCGKAF ISFTNFQSHM
IRHTGDGPYK CKVCGRAFIF PSYVRKHERT HTGEKPYECN KCGKTFSSSS NVRTHERTHT
GEKPYECKEC GKAFISLPSV RRHMIKHTGD GPYKCQVCGR AFDCPSSFQI HERTHTGEKP
YECQVCGKAF ISLKRIRKHM ILHTGDGPYK CQVCGKAFDC PSSVRTHERT HTGEKPYECK
ECGKAFNYAS SIRIHERTHT GEKPYECKQC GKTFSYSSSF QRHERAHNGD KPYVKNVGKL
SFITQPSNTC ENE
//
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