Entry sw:ZN527_HUMAN

ID   ZN527_HUMAN             Reviewed;         609 AA.
AC   Q8NB42; B4DVL5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   02-NOV-2016, entry version 122.
DE   RecName: Full=Zinc finger protein 527;
GN   Name=ZNF527; Synonyms=KIAA1829;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8NB42-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8NB42-2; Sequence=VSP_040341;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC   -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00119}.
DR   EMBL; AK301135; BAG62727.1; -; mRNA.
DR   EMBL; AK091585; BAC03701.1; -; mRNA.
DR   EMBL; AC008806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS42559.1; -. [Q8NB42-1]
DR   RefSeq; NP_115829.1; NM_032453.1. [Q8NB42-1]
DR   RefSeq; XP_005259386.1; XM_005259329.3. [Q8NB42-2]
DR   UniGene; Hs.590940; -.
DR   ProteinModelPortal; Q8NB42; -.
DR   SMR; Q8NB42; -.
DR   STRING; 9606.ENSP00000390179; -.
DR   iPTMnet; Q8NB42; -.
DR   PhosphoSitePlus; Q8NB42; -.
DR   BioMuta; ZNF527; -.
DR   DMDM; 317373306; -.
DR   EPD; Q8NB42; -.
DR   MaxQB; Q8NB42; -.
DR   PaxDb; Q8NB42; -.
DR   PeptideAtlas; Q8NB42; -.
DR   PRIDE; Q8NB42; -.
DR   Ensembl; ENST00000436120; ENSP00000390179; ENSG00000189164. [Q8NB42-1]
DR   GeneID; 84503; -.
DR   KEGG; hsa:84503; -.
DR   UCSC; uc010efk.2; human. [Q8NB42-1]
DR   CTD; 84503; -.
DR   DisGeNET; 84503; -.
DR   GeneCards; ZNF527; -.
DR   HGNC; HGNC:29385; ZNF527.
DR   HPA; HPA037740; -.
DR   HPA; HPA037741; -.
DR   neXtProt; NX_Q8NB42; -.
DR   OpenTargets; ENSG00000189164; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00840000129704; -.
DR   HOGENOM; HOG000234617; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8NB42; -.
DR   KO; K09228; -.
DR   OMA; WESWCEI; -.
DR   OrthoDB; EOG091G02KC; -.
DR   PhylomeDB; Q8NB42; -.
DR   BioCyc; ZFISH:ENSG00000171827-MONOMER; -.
DR   GenomeRNAi; 84503; -.
DR   PRO; PR:Q8NB42; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000189164; -.
DR   CleanEx; HS_ZNF527; -.
DR   ExpressionAtlas; Q8NB42; baseline and differential.
DR   Genevisible; Q8NB42; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 3.30.160.60; -; 12.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   Pfam; PF13912; zf-C2H2_6; 3.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    609       Zinc finger protein 527.
FT                                /FTId=PRO_0000047639.
FT   DOMAIN       14    123       KRAB. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00119}.
FT   ZN_FING     274    296       C2H2-type 1; degenerate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   ZN_FING     302    324       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     330    352       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     358    380       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     386    408       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     414    436       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     442    464       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     470    492       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     498    520       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     526    548       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     554    576       C2H2-type 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     582    604       C2H2-type 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   VAR_SEQ      54     85       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_040341.
FT   CONFLICT     57     57       I -> V (in Ref. 1; BAC03701/BAG62727).
FT                                {ECO:0000305}.
FT   CONFLICT    287    287       S -> P (in Ref. 1; BAG62727).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       330    352       ismart:ZnF_C2H2 [T]
FT   MYHIT       330    357       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       584    604       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       358    380       ismart:ZnF_C2H2 [T]
FT   MYHIT       414    441       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       442    464       ismart:ZnF_C2H2 [T]
FT   MYHIT        14     85       iprf:KRAB [T]
FT   MYHIT       554    576       ismart:ZnF_C2H2 [T]
FT   MYHIT       498    525       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT        13     54       ipfam:KRAB [T]
FT   MYHIT       472    492       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       582    609       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       526    548       ismart:ZnF_C2H2 [T]
FT   MYHIT       386    413       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       442    469       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT        14     74       ismart:KRAB [T]
FT   MYHIT       358    385       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       388    408       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       332    352       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       416    436       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       470    492       ismart:ZnF_C2H2 [T]
FT   MYHIT       444    464       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       386    408       ismart:ZnF_C2H2 [T]
FT   MYHIT       498    520       ismart:ZnF_C2H2 [T]
FT   MYHIT       554    581       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       274    301       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       556    576       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       582    604       ismart:ZnF_C2H2 [T]
FT   MYHIT       526    553       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       470    497       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       414    436       ismart:ZnF_C2H2 [T]
FT   MYHIT       302    324       ismart:ZnF_C2H2 [T]
FT   MYHIT       528    548       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       360    380       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       500    520       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       302    329       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       304    324       ipat:ZINC_FINGER_C2H2_1 [T]
SQ   SEQUENCE   609 AA;  70902 MW;  D1FEBF1EB02D41FB CRC64;
     MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LKPSQKDLYR DVMLENYRNL VWLGLSISKP
     NMISLLEQGK EPWMVERKMS QGHCADWESW CEIEELSPKW FIDEDEISQE MVMERLASHG
     LECSSFREAW KYKGEFELHQ GNAERHFMQV TAVKEISTGK RDNEFSNSGR SIPLKSVFLT
     QQKVPTIQQV HKFDIYDKLF PQNSVIIEYK RLHAEKESLI GNECEEFNQS TYLSKDIGIP
     PGEKPYESHD FSKLLSFHSL FTQHQTTHFG KLPHGYDECG DAFSCYSFFT QPQRIHSGEK
     PYACNDCGKA FSHDFFLSEH QRTHIGEKPY ECKECNKAFR QSAHLAQHQR IHTGEKPFAC
     NECGKAFSRY AFLVEHQRIH TGEKPYECKE CNKAFRQSAH LNQHQRIHTG EKPYECNQCG
     KAFSRRIALT LHQRIHTGEK PFKCSECGKT FGYRSHLNQH QRIHTGEKPY ECIKCGKFFR
     TDSQLNRHHR IHTGERPFEC SKCGKAFSDA LVLIHHKRSH AGEKPYECNK CGKAFSCGSY
     LNQHQRIHTG EKPYECSECG KAFHQILSLR LHQRIHAGEK PYKCNECGNN FSCVSALRRH
     QRIHNRETL
//