Entry sw:ZN526_MOUSE

ID   ZN526_MOUSE             Reviewed;         675 AA.
AC   Q8BI66; Q4VA17; Q69Z58; Q8BIH7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   30-NOV-2016, entry version 115.
DE   RecName: Full=Zinc finger protein 526;
GN   Name=Znf526; Synonyms=Kiaa1951, Zfp526;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=129; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-433.
RC   TISSUE=Pancreatic islet;
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene:
RT   IV. The complete nucleotide sequences of 500 mouse KIAA-homologous
RT   cDNAs identified by screening of terminal sequences of cDNA clones
RT   randomly sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BI66-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BI66-2; Sequence=VSP_028554, VSP_028555;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 13 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC34772.1; Type=Frameshift; Positions=24, 425; Evidence={ECO:0000305};
CC       Sequence=BAD32586.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC       Sequence=BAD32586.1; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence={ECO:0000305};
DR   EMBL; AK050839; BAC34430.1; -; mRNA.
DR   EMBL; AK051798; BAC34772.1; ALT_FRAME; mRNA.
DR   EMBL; BC096589; AAH96589.1; -; mRNA.
DR   EMBL; AK173308; BAD32586.1; ALT_SEQ; Transcribed_RNA.
DR   CCDS; CCDS20975.1; -. [Q8BI66-1]
DR   RefSeq; NP_780645.1; NM_175436.5. [Q8BI66-1]
DR   RefSeq; XP_006539778.1; XM_006539715.3. [Q8BI66-1]
DR   RefSeq; XP_006539779.1; XM_006539716.2. [Q8BI66-1]
DR   UniGene; Mm.129371; -.
DR   UniGene; Mm.294664; -.
DR   ProteinModelPortal; Q8BI66; -.
DR   SMR; Q8BI66; -.
DR   STRING; 10090.ENSMUSP00000053567; -.
DR   PhosphoSitePlus; Q8BI66; -.
DR   PaxDb; Q8BI66; -.
DR   PRIDE; Q8BI66; -.
DR   Ensembl; ENSMUST00000055604; ENSMUSP00000053567; ENSMUSG00000046541. [Q8BI66-1]
DR   GeneID; 210172; -.
DR   KEGG; mmu:210172; -.
DR   UCSC; uc009frw.1; mouse. [Q8BI66-1]
DR   CTD; 210172; -.
DR   MGI; MGI:2445181; Zfp526.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00670000098063; -.
DR   HOGENOM; HOG000065747; -.
DR   HOVERGEN; HBG103121; -.
DR   InParanoid; Q8BI66; -.
DR   OMA; TIMCTEL; -.
DR   OrthoDB; EOG091G05J3; -.
DR   PhylomeDB; Q8BI66; -.
DR   TreeFam; TF350791; -.
DR   PRO; PR:Q8BI66; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000046541; -.
DR   CleanEx; MM_ZFP526; -.
DR   Genevisible; Q8BI66; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 9.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   Pfam; PF13912; zf-C2H2_6; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    675       Zinc finger protein 526.
FT                                /FTId=PRO_0000306876.
FT   ZN_FING      56     78       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     108    130       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     140    163       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     200    222       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     312    334       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     339    361       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     367    389       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     395    416       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     447    470       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     477    499       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     505    527       C2H2-type 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     533    555       C2H2-type 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     578    600       C2H2-type 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS    171    203       Pro-rich.
FT   COMPBIAS    194    263       Glu-rich.
FT   COMPBIAS    610    624       Pro-rich.
FT   VAR_SEQ     446    453       QLPCPQCP -> LLLSRLFG (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_028554.
FT   VAR_SEQ     454    675       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_028555.
FT   CONFLICT     37     37       T -> I (in Ref. 1; BAC34772).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       341    361       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       578    605       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       447    470       ismart:ZnF_C2H2 [T]
FT   MYHIT       533    555       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       578    600       ismart:ZnF_C2H2 [T]
FT   MYHIT       339    366       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       339    361       ismart:ZnF_C2H2 [T]
FT   MYHIT        56     78       ismart:ZnF_C2H2 [T]
FT   MYHIT       533    555       ismart:ZnF_C2H2 [T]
FT   MYHIT       200    222       ismart:ZnF_C2H2 [T]
FT   MYHIT        56     78       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       140    163       ismart:ZnF_C2H2 [T]
FT   MYHIT       108    130       ismart:ZnF_C2H2 [T]
FT   MYHIT       479    499       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       367    394       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       477    499       ismart:ZnF_C2H2 [T]
FT   MYHIT       202    222       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       535    555       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       142    163       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       477    504       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       108    135       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       314    334       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       447    475       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       280    303       ismart:ZnF_C2H2 [T]
FT   MYHIT       367    389       ismart:ZnF_C2H2 [T]
FT   MYHIT        58     78       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       507    527       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       369    389       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       312    339       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       395    421       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       449    470       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       312    334       ismart:ZnF_C2H2 [T]
FT   MYHIT       505    532       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       505    527       ismart:ZnF_C2H2 [T]
FT   MYHIT       395    416       ismart:ZnF_C2H2 [T]
FT   MYHIT       580    600       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       110    130       ipat:ZINC_FINGER_C2H2_1 [T]
SQ   SEQUENCE   675 AA;  73971 MW;  7B9D84985B85AAC9 CRC64;
     MAEMVAEAAE IPTQSSGAVE ISTAVSGELA EMATAVTEMT SGEALASSLF FQHHQFMCSE
     CGSLYNTLEE VLSHQEQHLL TMSEEETLTT QDAGLEPELV PSTGEGPFQC GECSQLILSP
     SELLAHQDAH LQESASQIQY QCGDCQELFP SPELWVAHRK TQHLSSAADE PPSPLPPPTP
     PPPPPPPPPP PPPEVKMEPY ECPECSTLCA TPEEFLEHQG THFDSLEKEE HNGLEEEEED
     EEEGEEEEDD DDEETDEEEA SSELTADDTG SNKSTADSAQ SCGDCPQHCT SSGARHKHRR
     ASHGPASATH AFHCSQCQRS FSSANRLVAH GRAHVGGTHE CTTCSKVFKK AASLEQHQRL
     HRGEARYLCV DCGRGFGTEL TLVAHRRAHT ANPLHRCRCG KTFSNMTKFL YHRRTHTGKS
     GTPTRVATVS PAPAEPTPPP LPPPAQLPCP QCPKSFASAS RLSRHRRAVH GPPERRHRCG
     VCGKGFKKLV HVRNHLRTHT GERPFQCHSC GKTFASLANL SRHQLTHTGV RPYQCLDCGK
     RFTQSSNLQQ HRRLHLRPVA FARAPRLPIT GLYNKSPYYC GTCGRWFRAM AGLRLHQRVH
     ARARSLTLQP PRSPSPVPPP PPEPQQTIMC TELGETIAII ETSQPLALED TLQLCQAALG
     ASEASGLLQL DTAFV
//