Entry sw:ZN525_HUMAN

ID   ZN525_HUMAN             Reviewed;         197 AA.
AC   Q8N782; Q8TF23;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   30-NOV-2016, entry version 104.
DE   RecName: Full=Zinc finger protein 525;
GN   Name=ZNF525; Synonyms=KIAA1979;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-197.
RC   TISSUE=Brain;
RX   PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XXII.
RT   The complete sequences of 50 new cDNA clones which code for large
RT   proteins.";
RL   DNA Res. 8:319-327(2001).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 7 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB85565.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC       Sequence=BAC05417.1; Type=Frameshift; Positions=103; Evidence={ECO:0000305};
DR   EMBL; AK098804; BAC05417.1; ALT_FRAME; mRNA.
DR   EMBL; AC010467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB075859; BAB85565.1; ALT_SEQ; mRNA.
DR   UniGene; Hs.352638; -.
DR   ProteinModelPortal; Q8N782; -.
DR   SMR; Q8N782; -.
DR   STRING; 9606.ENSP00000417696; -.
DR   iPTMnet; Q8N782; -.
DR   PhosphoSitePlus; Q8N782; -.
DR   DMDM; 205371818; -.
DR   MaxQB; Q8N782; -.
DR   PaxDb; Q8N782; -.
DR   PeptideAtlas; Q8N782; -.
DR   PRIDE; Q8N782; -.
DR   Ensembl; ENST00000355326; ENSP00000408929; ENSG00000203326.
DR   GeneCards; ZNF525; -.
DR   HGNC; HGNC:29423; ZNF525.
DR   neXtProt; NX_Q8N782; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   HOGENOM; HOG000234617; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8N782; -.
DR   PhylomeDB; Q8N782; -.
DR   BioCyc; ZFISH:G66-33837-MONOMER; -.
DR   PRO; PR:Q8N782; -.
DR   Proteomes; UP000005640; Unplaced.
DR   Bgee; ENSG00000203326; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 8.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   Pfam; PF13912; zf-C2H2_6; 1.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    197       Zinc finger protein 525.
FT                                /FTId=PRO_0000047638.
FT   ZN_FING       1     11       C2H2-type 1; degenerate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   ZN_FING      17     39       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING      45     67       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING      73     95       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     101    123       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     129    151       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     157    179       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT        19     39       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       157    184       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       157    179       ismart:ZnF_C2H2 [T]
FT   MYHIT        73     95       ismart:ZnF_C2H2 [T]
FT   MYHIT        17     39       ismart:ZnF_C2H2 [T]
FT   MYHIT        73    100       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT        47     67       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT         1     16       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       101    123       ismart:ZnF_C2H2 [T]
FT   MYHIT        45     67       ismart:ZnF_C2H2 [T]
FT   MYHIT        45     72       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       103    123       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT        75     95       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT        17     44       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       129    151       ismart:ZnF_C2H2 [T]
FT   MYHIT       131    151       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       159    179       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       129    156       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       101    128       iprf:ZINC_FINGER_C2H2_2 [T]
SQ   SEQUENCE   197 AA;  23070 MW;  8622F86F6EBBCB7E CRC64;
     MSSLTYHHRL HTGEKPYKCE ECDKAFRHNS ALQRHRRIHT GEKPHKCNEC GKTFSQKSYL
     ACHRSIHTGK KPYECEECDK AFSFKSNLES HRITHTGEKP YKCNDCGKTF SHMSTLTCHR
     RLHTGEKPYK CEECDEAFRF KSSLERHRRI HNGEKLYKCN ECGKTFSQEL SLTCHCRLHS
     GEKPCKCGEC DKAYSFK
//