Legends: 1, SCAN box. {ECO:0000255|PROSITE- ProRule:PRU00187}; 2, ZN_FING C2H2-type 1. {ECO:0000255|PROSITE- ProRule:PRU00042}; 3, ZN_FING C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042}; 4, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 5, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, iprf:ZINC_FINGER_C2H2_2 [T]; 10, ismart:ZnF_C2H2 [T]; 11, ipat:ZINC_FINGER_C2H2_1 [T].
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ID ZN449_PANTR Reviewed; 518 AA.
AC A2T6W2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 05-OCT-2016, entry version 68.
DE RecName: Full=Zinc finger protein 449;
GN Name=ZNF449;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT "Positive selection in transcription factor genes on the human
RT lineage.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC ProRule:PRU00187}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 7 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 SCAN box domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00187}.
DR EMBL; DQ977317; ABM91917.1; -; Genomic_DNA.
DR RefSeq; NP_001074958.1; NM_001081489.1.
DR RefSeq; XP_009437948.1; XM_009439673.2.
DR UniGene; Ptr.6733; -.
DR ProteinModelPortal; A2T6W2; -.
DR STRING; 9598.ENSPTRP00000038417; -.
DR PaxDb; A2T6W2; -.
DR Ensembl; ENSPTRT00000041597; ENSPTRP00000038417; ENSPTRG00000022299.
DR GeneID; 473793; -.
DR KEGG; ptr:473793; -.
DR CTD; 203523; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00730000110971; -.
DR HOGENOM; HOG000234619; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; A2T6W2; -.
DR KO; K09230; -.
DR OMA; PVAEAWI; -.
DR OrthoDB; EOG091G02KC; -.
DR TreeFam; TF336949; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000022299; -.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 7.
DR InterPro; IPR008916; Retrov_capsid_C.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR Pfam; PF13912; zf-C2H2_6; 3.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF47353; SSF47353; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 518 Zinc finger protein 449.
FT /FTId=PRO_0000285476.
FT DOMAIN 30 112 SCAN box. {ECO:0000255|PROSITE-
FT ProRule:PRU00187}.
FT ZN_FING 323 345 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 351 373 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 379 401 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 407 429 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 435 457 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 463 485 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 491 513 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 323 350 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 463 485 ismart:ZnF_C2H2 [T]
FT MYHIT 491 513 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 353 373 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 435 457 ismart:ZnF_C2H2 [T]
FT MYHIT 465 485 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 381 401 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 407 429 ismart:ZnF_C2H2 [T]
FT MYHIT 379 406 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 437 457 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 491 513 ismart:ZnF_C2H2 [T]
FT MYHIT 351 378 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 325 345 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 30 112 iprf:SCAN_BOX [T]
FT MYHIT 435 462 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 351 373 ismart:ZnF_C2H2 [T]
FT MYHIT 379 401 ismart:ZnF_C2H2 [T]
FT MYHIT 409 429 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 463 490 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 26 134 ismart:SCAN [T]
FT MYHIT 323 345 ismart:ZnF_C2H2 [T]
FT MYHIT 493 513 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 407 434 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 27 113 ipfam:SCAN [T]
SQ SEQUENCE 518 AA; 60017 MW; 3B571B264AD82AF7 CRC64;
MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK LWELCCQWLK
PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER VVSLIEDLQR ELEIPEQQVD
MHDMLLEELA PVGTAHIPPT MHLESPALQV MGPAQEAPVA EAWIPQAGPP ELNYSATGEC
QNFLDPGYPL PKLDMNFSLE NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK
KMETMYPFIV TLEGNALQGP ILQKDYVQLE NQWETPPEDL QRDLAKLVDQ QNPTLGETPE
NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP HKCPECGKRF
LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT HSEEETYKCL ECGKSFCHGS
SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI
HLRIHTGEKP YKCTHCSKSF RQRAGLIMHQ VTHFRGLI
//
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