ID ZN439_HUMAN Reviewed; 499 AA.
AC Q8NDP4; Q8IYZ7; Q96SU1;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 30-NOV-2016, entry version 122.
DE RecName: Full=Zinc finger protein 439;
GN Name=ZNF439;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Substantia nigra;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-499.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-499, AND VARIANT
RP SER-427.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC O95273:CCNDBP1; NbExp=3; IntAct=EBI-747580, EBI-748961;
CC Q8NHQ1:CEP70; NbExp=3; IntAct=EBI-747580, EBI-739624;
CC O75496:GMNN; NbExp=5; IntAct=EBI-747580, EBI-371669;
CC Q6A162:KRT40; NbExp=5; IntAct=EBI-747580, EBI-10171697;
CC P60370:KRTAP10-5; NbExp=3; IntAct=EBI-747580, EBI-10172150;
CC P60409:KRTAP10-7; NbExp=3; IntAct=EBI-747580, EBI-10172290;
CC P60410:KRTAP10-8; NbExp=5; IntAct=EBI-747580, EBI-10171774;
CC P60411:KRTAP10-9; NbExp=3; IntAct=EBI-747580, EBI-10172052;
CC P26371:KRTAP5-9; NbExp=5; IntAct=EBI-747580, EBI-3958099;
CC Q99750:MDFI; NbExp=7; IntAct=EBI-747580, EBI-724076;
CC Q5JR59:MTUS2; NbExp=4; IntAct=EBI-747580, EBI-742948;
CC Q7Z3S9:NOTCH2NL; NbExp=3; IntAct=EBI-747580, EBI-945833;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 11 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB55187.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR EMBL; AL833935; CAD38790.1; -; mRNA.
DR EMBL; AK027542; BAB55187.1; ALT_INIT; mRNA.
DR EMBL; BC032857; AAH32857.1; -; mRNA.
DR CCDS; CCDS12268.1; -.
DR RefSeq; NP_689475.1; NM_152262.2.
DR UniGene; Hs.528731; -.
DR ProteinModelPortal; Q8NDP4; -.
DR SMR; Q8NDP4; -.
DR BioGrid; 124741; 15.
DR IntAct; Q8NDP4; 18.
DR MINT; MINT-1475050; -.
DR STRING; 9606.ENSP00000305077; -.
DR iPTMnet; Q8NDP4; -.
DR PhosphoSitePlus; Q8NDP4; -.
DR BioMuta; ZNF439; -.
DR DMDM; 30580628; -.
DR MaxQB; Q8NDP4; -.
DR PaxDb; Q8NDP4; -.
DR PeptideAtlas; Q8NDP4; -.
DR PRIDE; Q8NDP4; -.
DR Ensembl; ENST00000304030; ENSP00000305077; ENSG00000171291.
DR GeneID; 90594; -.
DR KEGG; hsa:90594; -.
DR UCSC; uc002msr.4; human.
DR CTD; 90594; -.
DR GeneCards; ZNF439; -.
DR HGNC; HGNC:20873; ZNF439.
DR HPA; HPA047845; -.
DR neXtProt; NX_Q8NDP4; -.
DR OpenTargets; ENSG00000171291; -.
DR PharmGKB; PA134886330; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119089; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8NDP4; -.
DR KO; K09228; -.
DR OMA; CHRHERS; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q8NDP4; -.
DR TreeFam; TF338854; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 90594; -.
DR PRO; PR:Q8NDP4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000171291; -.
DR CleanEx; HS_ZNF439; -.
DR ExpressionAtlas; Q8NDP4; baseline and differential.
DR Genevisible; Q8NDP4; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 13.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR Pfam; PF13912; zf-C2H2_6; 4.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 499 Zinc finger protein 439.
FT /FTId=PRO_0000047588.
FT DOMAIN 19 101 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 186 208 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 214 236 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 242 264 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 270 292 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 298 320 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 326 348 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 354 376 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 382 404 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 410 432 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 438 460 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 466 490 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VARIANT 6 6 P -> S (in dbSNP:rs10421552).
FT /FTId=VAR_052827.
FT VARIANT 427 427 L -> S (in dbSNP:rs10500209).
FT {ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_024216.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 384 404 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 272 292 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 18 59 ipfam:KRAB [T]
FT MYHIT 354 381 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 19 81 ismart:KRAB [T]
FT MYHIT 298 320 ismart:ZnF_C2H2 [T]
FT MYHIT 214 236 ismart:ZnF_C2H2 [T]
FT MYHIT 326 348 ismart:ZnF_C2H2 [T]
FT MYHIT 438 465 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 214 241 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 466 490 ismart:ZnF_C2H2 [T]
FT MYHIT 410 437 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 270 297 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 242 264 ismart:ZnF_C2H2 [T]
FT MYHIT 244 264 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 412 432 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 382 409 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 354 376 ismart:ZnF_C2H2 [T]
FT MYHIT 468 490 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 216 236 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 19 101 iprf:KRAB [T]
FT MYHIT 382 404 ismart:ZnF_C2H2 [T]
FT MYHIT 298 325 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 466 490 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 356 376 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 326 353 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 300 320 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 188 208 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 186 213 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 438 460 ismart:ZnF_C2H2 [T]
FT MYHIT 270 292 ismart:ZnF_C2H2 [T]
FT MYHIT 242 269 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 440 460 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 410 432 ismart:ZnF_C2H2 [T]
FT MYHIT 328 348 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 186 208 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 499 AA; 58395 MW; 483E3238E280F229 CRC64;
MLSLSPILLY TCEMFQDPVA FKDVAVNFTQ EEWALLDISQ KNLYREVMLE TFWNLTSIGK
KWKDQNIEYE YQNPRRNFRS VTEEKVNEIK EDSHCGETFT PVPDDRLNFQ KKKASPEVKS
CDSFVCEVGL GNSSSNMNIR GDTGHKACEC QEYGPKPWKS QQPKKAFRYH PSLRTQERDH
TGKKPYACKE CGKNIIYHSS IQRHMVVHSG DGPYKCKFCG KAFHCLSLYL IHERTHTGEK
PYECKQCGKS FSYSATHRIH ERTHIGEKPY ECQECGKAFH SPRSCHRHER SHMGEKAYQC
KECGKAFMCP RYVRRHERTH SRKKLYECKQ CGKALSSLTS FQTHIRMHSG ERPYECKTCG
KGFYSAKSFQ RHEKTHSGEK PYKCKQCGKA FTRSGSFRYH ERTHTGEKPY ECKQCGKAFR
SAPNLQLHGR THTGEKPYQC KECGKAFRSA SQLRIHRRIH TGEKPYECKK CGKAFRYVQN
FRFHERTQTH KNALWRKTL
//
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