ID ZN433_HUMAN Reviewed; 673 AA.
AC Q8N7K0; Q86VX3;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 30-NOV-2016, entry version 125.
DE RecName: Full=Zinc finger protein 433;
GN Name=ZNF433;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P60370:KRTAP10-5; NbExp=3; IntAct=EBI-10267553, EBI-10172150;
CC P60409:KRTAP10-7; NbExp=3; IntAct=EBI-10267553, EBI-10172290;
CC Q99750:MDFI; NbExp=3; IntAct=EBI-10267553, EBI-724076;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N7K0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N7K0-2; Sequence=VSP_035523;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 19 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
DR EMBL; AK098300; BAC05279.1; -; mRNA.
DR EMBL; CH471106; EAW84254.1; -; Genomic_DNA.
DR EMBL; BC047412; AAH47412.1; -; mRNA.
DR CCDS; CCDS45983.1; -. [Q8N7K0-1]
DR CCDS; CCDS77240.1; -. [Q8N7K0-2]
DR RefSeq; NP_001073880.1; NM_001080411.2. [Q8N7K0-1]
DR RefSeq; NP_001295275.1; NM_001308346.1.
DR RefSeq; NP_001295277.1; NM_001308348.1.
DR RefSeq; NP_001295280.1; NM_001308351.1. [Q8N7K0-2]
DR RefSeq; NP_001295284.1; NM_001308355.1. [Q8N7K0-2]
DR RefSeq; NP_001295286.1; NM_001308357.1. [Q8N7K0-2]
DR RefSeq; XP_006722724.1; XM_006722661.3. [Q8N7K0-2]
DR UniGene; Hs.667776; -.
DR ProteinModelPortal; Q8N7K0; -.
DR SMR; Q8N7K0; -.
DR BioGrid; 127846; 7.
DR IntAct; Q8N7K0; 5.
DR STRING; 9606.ENSP00000339767; -.
DR iPTMnet; Q8N7K0; -.
DR PhosphoSitePlus; Q8N7K0; -.
DR BioMuta; ZNF433; -.
DR DMDM; 30173446; -.
DR MaxQB; Q8N7K0; -.
DR PaxDb; Q8N7K0; -.
DR PeptideAtlas; Q8N7K0; -.
DR PRIDE; Q8N7K0; -.
DR DNASU; 163059; -.
DR Ensembl; ENST00000344980; ENSP00000339767; ENSG00000197647. [Q8N7K0-1]
DR Ensembl; ENST00000419886; ENSP00000393416; ENSG00000197647. [Q8N7K0-2]
DR GeneID; 163059; -.
DR KEGG; hsa:163059; -.
DR UCSC; uc002msy.2; human. [Q8N7K0-1]
DR CTD; 163059; -.
DR DisGeNET; 163059; -.
DR GeneCards; ZNF433; -.
DR HGNC; HGNC:20811; ZNF433.
DR neXtProt; NX_Q8N7K0; -.
DR OpenTargets; ENSG00000197647; -.
DR PharmGKB; PA134943717; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119089; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8N7K0; -.
DR KO; K09228; -.
DR OMA; RYHGRTH; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q8N7K0; -.
DR TreeFam; TF343410; -.
DR BioCyc; ZFISH:G66-33835-MONOMER; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 163059; -.
DR PRO; PR:Q8N7K0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000197647; -.
DR CleanEx; HS_ZNF433; -.
DR ExpressionAtlas; Q8N7K0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 20.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF13912; zf-C2H2_6; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 673 Zinc finger protein 433.
FT /FTId=PRO_0000047581.
FT DOMAIN 7 85 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 142 164 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 170 192 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 198 220 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 226 248 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 254 276 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 282 304 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 310 332 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 338 360 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 366 388 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 394 416 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 422 444 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 450 472 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 478 500 C2H2-type 13; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 506 528 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 534 556 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 562 584 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 590 612 C2H2-type 17. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 618 640 C2H2-type 18. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 646 668 C2H2-type 19. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 1 35 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_035523.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 620 640 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 422 444 ismart:ZnF_C2H2 [T]
FT MYHIT 618 640 ismart:ZnF_C2H2 [T]
FT MYHIT 648 668 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 338 365 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 226 248 ismart:ZnF_C2H2 [T]
FT MYHIT 340 360 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 172 192 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 422 449 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 478 500 ismart:ZnF_C2H2 [T]
FT MYHIT 478 505 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 144 164 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 312 332 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 142 169 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 310 337 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 282 309 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 228 248 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 450 472 ismart:ZnF_C2H2 [T]
FT MYHIT 590 617 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 394 421 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 282 304 ismart:ZnF_C2H2 [T]
FT MYHIT 450 477 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 198 225 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 506 533 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 368 388 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 508 528 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 226 253 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 646 673 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 200 220 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 256 276 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 366 393 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 142 164 ismart:ZnF_C2H2 [T]
FT MYHIT 618 645 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 534 561 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 310 332 ismart:ZnF_C2H2 [T]
FT MYHIT 562 584 ismart:ZnF_C2H2 [T]
FT MYHIT 394 416 ismart:ZnF_C2H2 [T]
FT MYHIT 396 416 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 170 192 ismart:ZnF_C2H2 [T]
FT MYHIT 646 668 ismart:ZnF_C2H2 [T]
FT MYHIT 7 67 ismart:KRAB [T]
FT MYHIT 592 612 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 170 197 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 198 220 ismart:ZnF_C2H2 [T]
FT MYHIT 338 360 ismart:ZnF_C2H2 [T]
FT MYHIT 506 528 ismart:ZnF_C2H2 [T]
FT MYHIT 452 472 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 536 556 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 284 304 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 590 612 ismart:ZnF_C2H2 [T]
FT MYHIT 564 584 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 254 276 ismart:ZnF_C2H2 [T]
FT MYHIT 254 281 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 534 556 ismart:ZnF_C2H2 [T]
FT MYHIT 366 388 ismart:ZnF_C2H2 [T]
FT MYHIT 424 444 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 562 589 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 6 47 ipfam:KRAB [T]
FT MYHIT 7 85 iprf:KRAB [T]
SQ SEQUENCE 673 AA; 77243 MW; 8C8B1B6D272D08FC CRC64;
MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW KPQNIYVEYE
NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG VKSCESSVYG EVGSAHSSLN
RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP FNCLSSVQTH ERAHSGRKLY VCEECGKTFI
SHSNLQRHRI MHRGDGPYKC KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS
LRIHERTHTG EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH
ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL TSFQNHLGMH
TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG KAFNSSSSFR YHERTHTGEK
PYECKQCGKA FRSASLLQTH GRTHTGEKPY ACKECGKPFS NFSFFQIHER MHREEKPYEC
KGYGKTFSLP SLFHRHERTH TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG
KAFRSASQLQ IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG
CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ CGKVFRCSSQ
LQVHGRAHCI DTP
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