Entry sw:ZN414_MOUSE

ID   ZN414_MOUSE             Reviewed;         299 AA.
AC   Q9DCK4; Q8CHU9;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   02-NOV-2016, entry version 110.
DE   RecName: Full=Zinc finger protein 414;
GN   Name=Znf414; Synonyms=Zfp414;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Dendritic cell, and Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=129/Sv;
RX   PubMed=15112104; DOI=10.1007/s00335-003-2329-1;
RA   Abe K., Yuzuriha M., Sugimoto M., Ko M.S., Brathwaite M.E., Waeltz P.,
RA   Nagaraja R.;
RT   "Gene content of the 750-kb critical region for mouse embryonic
RT   ectoderm lethal tcl-w5.";
RL   Mamm. Genome 15:265-276(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9DCK4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9DCK4-2; Sequence=VSP_019454;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR   EMBL; AK002706; BAB22300.1; -; mRNA.
DR   EMBL; AK169869; BAE41424.1; -; mRNA.
DR   EMBL; AF528163; AAO17381.1; -; Genomic_DNA.
DR   EMBL; BC038913; AAH38913.1; -; mRNA.
DR   CCDS; CCDS37568.1; -. [Q9DCK4-1]
DR   RefSeq; NP_080988.1; NM_026712.3. [Q9DCK4-1]
DR   UniGene; Mm.181488; -.
DR   ProteinModelPortal; Q9DCK4; -.
DR   STRING; 10090.ENSMUSP00000073259; -.
DR   PhosphoSitePlus; Q9DCK4; -.
DR   PaxDb; Q9DCK4; -.
DR   PRIDE; Q9DCK4; -.
DR   Ensembl; ENSMUST00000073570; ENSMUSP00000073259; ENSMUSG00000073423. [Q9DCK4-1]
DR   Ensembl; ENSMUST00000166627; ENSMUSP00000129423; ENSMUSG00000073423. [Q9DCK4-2]
DR   GeneID; 328801; -.
DR   KEGG; mmu:328801; -.
DR   UCSC; uc008byw.2; mouse. [Q9DCK4-1]
DR   CTD; 328801; -.
DR   MGI; MGI:1915641; Zfp414.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00390000006876; -.
DR   HOGENOM; HOG000015387; -.
DR   HOVERGEN; HBG083015; -.
DR   InParanoid; Q9DCK4; -.
DR   OMA; EGECPVF; -.
DR   OrthoDB; EOG091G0DB2; -.
DR   PhylomeDB; Q9DCK4; -.
DR   TreeFam; TF337512; -.
DR   PRO; PR:Q9DCK4; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   Bgee; ENSMUSG00000073423; -.
DR   CleanEx; MM_ZFP414; -.
DR   ExpressionAtlas; Q9DCK4; baseline and differential.
DR   Genevisible; Q9DCK4; MM.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR031799; Znf-C2H2_ribbon.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   Pfam; PF15909; zf-C2H2_8; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    299       Zinc finger protein 414.
FT                                /FTId=PRO_0000242164.
FT   ZN_FING      99    123       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     135    159       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     166    190       C2H2-type 3; degenerate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   VAR_SEQ       1     49       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334,
FT                                ECO:0000303|PubMed:16141072}.
FT                                /FTId=VSP_019454.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       137    159       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       166    195       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       101    123       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       100    197       ipfam:zf-C2H2_8 [T]
FT   MYHIT        99    123       ismart:ZnF_C2H2 [T]
FT   MYHIT       135    159       ismart:ZnF_C2H2 [T]
FT   MYHIT       135    164       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       166    191       ismart:ZnF_C2H2 [T]
SQ   SEQUENCE   299 AA;  31988 MW;  D68D58D7D28C5DDB CRC64;
     MEEPSRPSSD TLTTVESSSG EPDKEVASPD GAAPATFSSV EEPSPNPTAM PPVWDHGGPL
     QQVAYPASDS CQTGSTNTGV GTNEDLRLPR RRPPPGKQIP CSSPGCCLSF PSVRDLAQHL
     RTHCPPTQSL EGKLFRCSAL SCTESFPSMQ ELVAHGKLHY KPNRYFKCEN CLLRFRTHRS
     LFKHLHVCID HGQNPAPPPP PALDKEPPVP ERPPESDPSS SLGLPFPLLE PFTSAPTGPF
     LPYLNPAPFG LSPPRLRPFL AATPGPPASS TAIWKKSQGA TSSPRRPQGG SDAPSGACR
//