Entry sw:ZN414_HUMAN

ID   ZN414_HUMAN             Reviewed;         312 AA.
AC   Q96IQ9; A8MY94;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 2.
DT   30-NOV-2016, entry version 125.
DE   RecName: Full=Zinc finger protein 414;
GN   Name=ZNF414;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP   SER-77.
RC   TISSUE=Adipose tissue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP   ARG-65.
RC   TISSUE=Eye, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q08379:GOLGA2; NbExp=3; IntAct=EBI-744257, EBI-618309;
CC       Q9NYB0:TERF2IP; NbExp=2; IntAct=EBI-744257, EBI-750109;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96IQ9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96IQ9-2; Sequence=VSP_045351;
CC         Note=No experimental confirmation available. Ref.1 (AK074191)
CC         sequence is in conflict in position: 357:A->P. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR   EMBL; AK074191; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC092298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471139; EAW68915.1; -; Genomic_DNA.
DR   EMBL; BC007310; AAH07310.1; -; mRNA.
DR   EMBL; BC071937; AAH71937.1; -; mRNA.
DR   CCDS; CCDS12205.1; -. [Q96IQ9-1]
DR   CCDS; CCDS54211.1; -. [Q96IQ9-2]
DR   RefSeq; NP_001139647.1; NM_001146175.1. [Q96IQ9-2]
DR   RefSeq; NP_115746.2; NM_032370.2. [Q96IQ9-1]
DR   UniGene; Hs.515114; -.
DR   ProteinModelPortal; Q96IQ9; -.
DR   SMR; Q96IQ9; -.
DR   BioGrid; 124054; 39.
DR   IntAct; Q96IQ9; 26.
DR   MINT; MINT-1469011; -.
DR   STRING; 9606.ENSP00000377504; -.
DR   iPTMnet; Q96IQ9; -.
DR   PhosphoSitePlus; Q96IQ9; -.
DR   BioMuta; ZNF414; -.
DR   DMDM; 125987870; -.
DR   MaxQB; Q96IQ9; -.
DR   PaxDb; Q96IQ9; -.
DR   PeptideAtlas; Q96IQ9; -.
DR   PRIDE; Q96IQ9; -.
DR   DNASU; 84330; -.
DR   Ensembl; ENST00000255616; ENSP00000255616; ENSG00000133250. [Q96IQ9-1]
DR   Ensembl; ENST00000393927; ENSP00000377504; ENSG00000133250. [Q96IQ9-2]
DR   GeneID; 84330; -.
DR   KEGG; hsa:84330; -.
DR   UCSC; uc002mke.5; human. [Q96IQ9-1]
DR   CTD; 84330; -.
DR   GeneCards; ZNF414; -.
DR   HGNC; HGNC:20630; ZNF414.
DR   HPA; HPA053769; -.
DR   neXtProt; NX_Q96IQ9; -.
DR   OpenTargets; ENSG00000133250; -.
DR   PharmGKB; PA142670521; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00390000006876; -.
DR   HOGENOM; HOG000015387; -.
DR   HOVERGEN; HBG083015; -.
DR   InParanoid; Q96IQ9; -.
DR   OMA; EGECPVF; -.
DR   OrthoDB; EOG091G0DB2; -.
DR   PhylomeDB; Q96IQ9; -.
DR   TreeFam; TF337512; -.
DR   BioCyc; ZFISH:ENSG00000133250-MONOMER; -.
DR   ChiTaRS; ZNF414; human.
DR   GenomeRNAi; 84330; -.
DR   PRO; PR:Q96IQ9; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000133250; -.
DR   CleanEx; HS_ZNF414; -.
DR   ExpressionAtlas; Q96IQ9; baseline and differential.
DR   Genevisible; Q96IQ9; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR031799; Znf-C2H2_ribbon.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   Pfam; PF15909; zf-C2H2_8; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    312       Zinc finger protein 414.
FT                                /FTId=PRO_0000242163.
FT   ZN_FING     109    133       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     145    169       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     176    201       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   VAR_SEQ     310    312       ACR -> HAAPSRIVWEHTRGRYSCMQCAFSTASRPAMTLH
FT                                LEDHRPGAPAAPAAGPPRPDAPADPAPLAPKVSPLLSEGEL
FT                                PVFSQL (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_045351.
FT   VARIANT      65     65       Q -> R (in dbSNP:rs8100431).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_026847.
FT   VARIANT      77     77       P -> S (in dbSNP:rs1064010).
FT                                {ECO:0000269|PubMed:14702039}.
FT                                /FTId=VAR_026848.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       145    174       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       176    201       ismart:ZnF_C2H2 [T]
FT   MYHIT       145    169       ismart:ZnF_C2H2 [T]
FT   MYHIT       110    207       ipfam:zf-C2H2_8 [T]
FT   MYHIT       109    133       ismart:ZnF_C2H2 [T]
FT   MYHIT       111    133       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT       147    169       ipat:ZINC_FINGER_C2H2_1 [T]
SQ   SEQUENCE   312 AA;  32782 MW;  B3DFB0C66CD09796 CRC64;
     MEEKPSGPIP DMLATAEPSS SETDKEVLSP AVPAAAPSSS MSEEPGPEQA ATPPVWERGG
     AGGMQQGSSP APDSCQPGPG PSPGLTSIVS GTSEDLRPPR RRPPPGKQIP CSSPGCCLSF
     PSVRDLAQHL RTHCPPTQSL EGKLFRCSAL SCTETFPSMQ ELVAHSKLHY KPNRYFKCEN
     CLLRFRTHRS LFKHLHVCAE HAQSPAPPPP PALDREPPAP ERPPEVDPAS APGLPFPLLE
     PFTTPAPAPT GPFLPYLNPA PFGLSPPRLR PFLAAAPGPP ASSAAVWKKS QGAGSSPRRP
     QGGSDAPSGA CR
//