ID ZN343_HUMAN Reviewed; 599 AA.
AC Q6P1L6; Q5JXU8; Q5JXU9; Q8N8F2; Q96EX8; Q96NA5; Q9BQB0;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 02-NOV-2016, entry version 118.
DE RecName: Full=Zinc finger protein 343;
GN Name=ZNF343;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Lung, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9UMX0:UBQLN1; NbExp=3; IntAct=EBI-10252492, EBI-741480;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6P1L6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P1L6-2; Sequence=VSP_016028;
CC Note=No experimental confirmation available.;
CC Name=3;
CC IsoId=Q6P1L6-3; Sequence=VSP_016029, VSP_016030;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
DR EMBL; AK055734; BAB71000.1; -; mRNA.
DR EMBL; AK096911; BAC04892.1; -; mRNA.
DR EMBL; AL049650; CAB46713.2; -; Genomic_DNA.
DR EMBL; AL049650; CAI22572.1; -; Genomic_DNA.
DR EMBL; AL049650; CAI22573.1; -; Genomic_DNA.
DR EMBL; AL049650; CAI22574.1; -; Genomic_DNA.
DR EMBL; BC002897; AAH02897.1; -; mRNA.
DR EMBL; BC011862; AAH11862.2; -; mRNA.
DR EMBL; BC065009; AAH65009.1; -; mRNA.
DR CCDS; CCDS13028.1; -. [Q6P1L6-1]
DR CCDS; CCDS74692.1; -. [Q6P1L6-2]
DR CCDS; CCDS74694.1; -. [Q6P1L6-3]
DR RefSeq; NP_001269424.1; NM_001282495.1. [Q6P1L6-1]
DR RefSeq; NP_001269425.1; NM_001282496.1. [Q6P1L6-1]
DR RefSeq; NP_001269426.1; NM_001282497.1.
DR RefSeq; NP_001269427.1; NM_001282498.1. [Q6P1L6-2]
DR RefSeq; NP_001269428.1; NM_001282499.1. [Q6P1L6-3]
DR RefSeq; NP_001308729.1; NM_001321800.1. [Q6P1L6-1]
DR RefSeq; NP_001308730.1; NM_001321801.1.
DR RefSeq; NP_001308731.1; NM_001321802.1.
DR RefSeq; NP_001308732.1; NM_001321803.1.
DR RefSeq; NP_001308734.1; NM_001321805.1.
DR RefSeq; NP_077301.4; NM_024325.5. [Q6P1L6-1]
DR RefSeq; XP_016883551.1; XM_017028062.1. [Q6P1L6-1]
DR UniGene; Hs.516846; -.
DR ProteinModelPortal; Q6P1L6; -.
DR SMR; Q6P1L6; -.
DR BioGrid; 122592; 3.
DR IntAct; Q6P1L6; 1.
DR STRING; 9606.ENSP00000278772; -.
DR iPTMnet; Q6P1L6; -.
DR PhosphoSitePlus; Q6P1L6; -.
DR BioMuta; ZNF343; -.
DR DMDM; 74762346; -.
DR PaxDb; Q6P1L6; -.
DR PeptideAtlas; Q6P1L6; -.
DR PRIDE; Q6P1L6; -.
DR Ensembl; ENST00000278772; ENSP00000278772; ENSG00000088876. [Q6P1L6-1]
DR Ensembl; ENST00000358413; ENSP00000351188; ENSG00000088876. [Q6P1L6-3]
DR Ensembl; ENST00000381253; ENSP00000370652; ENSG00000088876. [Q6P1L6-3]
DR Ensembl; ENST00000617391; ENSP00000483851; ENSG00000088876. [Q6P1L6-2]
DR GeneID; 79175; -.
DR KEGG; hsa:79175; -.
DR UCSC; uc002wge.2; human. [Q6P1L6-1]
DR CTD; 79175; -.
DR DisGeNET; 79175; -.
DR GeneCards; ZNF343; -.
DR HGNC; HGNC:16017; ZNF343.
DR HPA; HPA030587; -.
DR HPA; HPA052438; -.
DR neXtProt; NX_Q6P1L6; -.
DR OpenTargets; ENSG00000088876; -.
DR PharmGKB; PA38081; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00530000063157; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q6P1L6; -.
DR KO; K09228; -.
DR PhylomeDB; Q6P1L6; -.
DR TreeFam; TF338096; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR ChiTaRS; ZNF343; human.
DR GenomeRNAi; 79175; -.
DR PRO; PR:Q6P1L6; -.
DR Proteomes; UP000005640; Chromosome 20.
DR Bgee; ENSG00000088876; -.
DR CleanEx; HS_ZNF343; -.
DR ExpressionAtlas; Q6P1L6; baseline and differential.
DR Genevisible; Q6P1L6; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 599 Zinc finger protein 343.
FT /FTId=PRO_0000047543.
FT DOMAIN 62 139 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 269 291 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 297 319 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 325 347 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 353 375 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 381 403 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 409 431 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 437 459 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 465 487 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 493 515 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 521 543 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 549 571 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 577 599 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 1 90 Missing (in isoform 2).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_016028.
FT VAR_SEQ 102 118 AEPKPEIYTCSSCLLAF -> GQEIETILANIVKSHLY
FT (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_016029.
FT VAR_SEQ 119 599 Missing (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_016030.
FT VARIANT 520 520 P -> L (in dbSNP:rs6049415).
FT /FTId=VAR_059912.
FT CONFLICT 418 418 F -> S (in Ref. 1; BAC04892).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 355 375 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 269 291 ismart:ZnF_C2H2 [T]
FT MYHIT 439 459 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 577 599 ismart:ZnF_C2H2 [T]
FT MYHIT 299 319 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 381 408 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 409 436 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 467 487 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 465 492 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 493 520 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 353 380 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 551 571 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 437 464 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 495 515 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 297 324 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 523 543 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 493 515 ismart:ZnF_C2H2 [T]
FT MYHIT 325 352 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 327 347 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 62 139 iprf:KRAB [T]
FT MYHIT 409 431 ismart:ZnF_C2H2 [T]
FT MYHIT 383 403 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 353 375 ismart:ZnF_C2H2 [T]
FT MYHIT 271 291 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 411 431 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 549 576 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 579 599 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 521 543 ismart:ZnF_C2H2 [T]
FT MYHIT 549 571 ismart:ZnF_C2H2 [T]
FT MYHIT 61 101 ipfam:KRAB [T]
FT MYHIT 521 548 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 577 599 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 465 487 ismart:ZnF_C2H2 [T]
FT MYHIT 381 403 ismart:ZnF_C2H2 [T]
FT MYHIT 297 319 ismart:ZnF_C2H2 [T]
FT MYHIT 325 347 ismart:ZnF_C2H2 [T]
FT MYHIT 269 296 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 62 121 ismart:KRAB [T]
FT MYHIT 437 459 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 599 AA; 69220 MW; 121CC71CBA462DF9 CRC64;
MMLPYPSALG DQYWEEILLP KNGENVETMK KLTQNHKAKG LPSNDTDCPQ KKEGKAQIVV
PVTFRDVTVI FTEAEWKRLS PEQRNLYKEV MLENYRNLLS LAEPKPEIYT CSSCLLAFSC
QQFLSQHVLQ IFLGLCAENH FHPGNSSPGH WKQQGQQYSH VSCWFENAEG QERGGGSKPW
SARTEERETS RAFPSPLQRQ SASPRKGNMV VETEPSSAQR PNPVQLDKGL KELETLRFGA
INCREYEPDH NLESNFITNP RTLLGKKPYI CSDCGRSFKD RSTLIRHHRI HSMEKPYVCS
ECGRGFSQKS NLSRHQRTHS EEKPYLCREC GQSFRSKSIL NRHQWTHSEE KPYVCSECGR
GFSEKSSFIR HQRTHSGEKP YVCLECGRSF CDKSTLRKHQ RIHSGEKPYV CRECGRGFSQ
NSDLIKHQRT HLDEKPYVCR ECGRGFCDKS TLIIHERTHS GEKPYVCGEC GRGFSRKSLL
LVHQRTHSGE KHYVCRECRR GFSQKSNLIR HQRTHSNEKP YICRECGRGF CDKSTLIVHE
RTHSGEKPYV CSECGRGFSR KSLLLVHQRT HSGEKHYVCR ECGRGFSHKS NLIRHQRTH
//
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