ID ZN322_MOUSE Reviewed; 410 AA.
AC Q8BZ89; Q8K0A0; Q91W42;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 02-NOV-2016, entry version 118.
DE RecName: Full=Zinc finger protein 322;
DE AltName: Full=Zinc finger protein 322A;
GN Name=Znf322; Synonyms=Zfp322a, Znf322a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Eye, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in transcriptional regulation as an activator.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 10 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32268.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
DR EMBL; AK036302; BAC29377.1; -; mRNA.
DR EMBL; AK162608; BAE36986.1; -; mRNA.
DR EMBL; AK170525; BAE41858.1; -; mRNA.
DR EMBL; AL669819; CAI26123.1; -; Genomic_DNA.
DR EMBL; BC017143; AAH17143.1; -; mRNA.
DR EMBL; BC032268; AAH32268.1; ALT_INIT; mRNA.
DR EMBL; BC043711; AAH43711.1; -; mRNA.
DR CCDS; CCDS26337.1; -.
DR RefSeq; NP_001104577.1; NM_001111107.2.
DR RefSeq; NP_001273084.1; NM_001286155.1.
DR RefSeq; NP_001273085.1; NM_001286156.1.
DR RefSeq; NP_766174.1; NM_172586.4.
DR UniGene; Mm.286454; -.
DR ProteinModelPortal; Q8BZ89; -.
DR SMR; Q8BZ89; -.
DR STRING; 10090.ENSMUSP00000061524; -.
DR iPTMnet; Q8BZ89; -.
DR PhosphoSitePlus; Q8BZ89; -.
DR PaxDb; Q8BZ89; -.
DR PRIDE; Q8BZ89; -.
DR Ensembl; ENSMUST00000050101; ENSMUSP00000061524; ENSMUSG00000046351.
DR GeneID; 218100; -.
DR KEGG; mmu:218100; -.
DR UCSC; uc007ptn.3; mouse.
DR CTD; 218100; -.
DR MGI; MGI:2442566; Zfp322a.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00790000123153; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8BZ89; -.
DR OMA; STCESGF; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q8BZ89; -.
DR TreeFam; TF338126; -.
DR PRO; PR:Q8BZ89; -.
DR Proteomes; UP000000589; Chromosome 13.
DR Bgee; ENSMUSG00000046351; -.
DR CleanEx; MM_ZFP322A; -.
DR ExpressionAtlas; Q8BZ89; baseline and differential.
DR Genevisible; Q8BZ89; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 10.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 10.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Activator; Complete proteome; Cytoplasm; DNA-binding; Metal-binding;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 410 Zinc finger protein 322.
FT /FTId=PRO_0000047531.
FT ZN_FING 81 103 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 109 131 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 137 159 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 165 187 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 193 215 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 221 243 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 249 271 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 277 299 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 303 325 C2H2-type 9; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 361 383 C2H2-type 10; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT MOD_RES 400 400 Phosphoserine.
FT {ECO:0000250|UniProtKB:Q6U7Q0}.
FT CONFLICT 1 1 M -> V (in Ref. 3; AAH32268).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 221 243 ismart:ZnF_C2H2 [T]
FT MYHIT 223 243 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 165 192 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 221 248 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 81 103 ismart:ZnF_C2H2 [T]
FT MYHIT 303 330 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 139 159 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 167 187 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 137 164 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 111 131 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 109 131 ismart:ZnF_C2H2 [T]
FT MYHIT 251 271 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 109 136 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 277 300 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 137 159 ismart:ZnF_C2H2 [T]
FT MYHIT 249 276 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 193 215 ismart:ZnF_C2H2 [T]
FT MYHIT 277 299 ismart:ZnF_C2H2 [T]
FT MYHIT 361 383 ismart:ZnF_C2H2 [T]
FT MYHIT 249 271 ismart:ZnF_C2H2 [T]
FT MYHIT 195 215 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 193 220 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 303 325 ismart:ZnF_C2H2 [T]
FT MYHIT 165 187 ismart:ZnF_C2H2 [T]
FT MYHIT 81 108 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 361 388 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 83 103 ipat:ZINC_FINGER_C2H2_1 [T]
SQ SEQUENCE 410 AA; 48492 MW; 27E5668CC383FAA7 CRC64;
MENHLGENHR RCTLQKRNVT RELKKGKHTM YALKRVKKIY IRVHEITQID NQTYQCLERE
QNFCENLARM CERTYTEEKP YRCDMCEKTF IQSSDLISHQ RIHNYEKPYK CSKCEKSFWH
HLALSGHQRT HAGKKFYTCD ICGKNFGQSS DLLVHQRSHT GEKPYLCNEC DKCFSRSTNL
IRHRRTHTGE KPFKCLECEK AFSGKSDLIS HQRTHTGERP YKCNKCEKSY RHRSAFIVHK
RVHTGEKPYK CGACEKCFGQ KSDLIVHQRV HTGEKPYKCL ECMRSFTRSA NLIRHQATHT
HTFKCLEYEK SFNCSSDFIV HQRIHMEEKP HQWSMCESDF LLGMDFVAQQ KMRAQTEELH
YKYSVCDKTF HHSSALLQHQ TVHIDDEYIC NMSEKGLDLS SHASETSRVS
//
|
