ID ZN235_HUMAN Reviewed; 738 AA.
AC Q14590; B4DTQ7; O14898; O14899; Q17RR8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 02-NOV-2016, entry version 156.
DE RecName: Full=Zinc finger protein 235;
DE AltName: Full=Zinc finger protein 270;
DE AltName: Full=Zinc finger protein 93 homolog;
DE Short=Zfp-93;
DE AltName: Full=Zinc finger protein HZF6;
GN Name=ZNF235; Synonyms=ZFP93, ZNF270;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP PRO-296.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-506 (ISOFORM 1), AND NUCLEOTIDE
RP SEQUENCE [MRNA] OF 637-738 (ISOFORMS 1/2).
RX PubMed=9570955; DOI=10.1006/geno.1998.5230;
RA Shannon M., Stubbs L.;
RT "Analysis of homologous XRCC1-linked zinc-finger gene families in
RT human and mouse: evidence for orthologous genes.";
RL Genomics 49:112-121(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 456-664 (ISOFORMS 1/2).
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 637-738 (ISOFORMS 1/2).
RA Kodoyianni V., Ge Y., Krummel G.K., Kvikstad E., Grable L.,
RA Severin J., Gordon L., Shannon M., Brower A., Olsen A.S., Smith L.M.;
RT "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger
RT gene cluster.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14590-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14590-2; Sequence=VSP_022166;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 16 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
DR EMBL; AK300317; BAG62069.1; -; mRNA.
DR EMBL; AC092477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC138473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117215; AAI17216.1; -; mRNA.
DR EMBL; AF027513; AAD12728.1; -; mRNA.
DR EMBL; AF027514; AAD12729.1; -; mRNA.
DR EMBL; X78929; CAA55529.1; -; mRNA.
DR EMBL; AC084239; AAG23969.1; -; Genomic_DNA.
DR CCDS; CCDS33048.1; -. [Q14590-1]
DR PIR; S47068; S47068.
DR RefSeq; NP_004225.3; NM_004234.4. [Q14590-1]
DR RefSeq; XP_005259469.1; XM_005259412.4. [Q14590-2]
DR UniGene; Hs.613424; -.
DR UniGene; Hs.724032; -.
DR ProteinModelPortal; Q14590; -.
DR SMR; Q14590; -.
DR BioGrid; 114722; 5.
DR IntAct; Q14590; 5.
DR MINT; MINT-8247407; -.
DR STRING; 9606.ENSP00000291182; -.
DR iPTMnet; Q14590; -.
DR PhosphoSitePlus; Q14590; -.
DR BioMuta; ZNF235; -.
DR DMDM; 215274192; -.
DR PaxDb; Q14590; -.
DR PeptideAtlas; Q14590; -.
DR PRIDE; Q14590; -.
DR Ensembl; ENST00000291182; ENSP00000291182; ENSG00000159917. [Q14590-1]
DR GeneID; 9310; -.
DR KEGG; hsa:9310; -.
DR UCSC; uc002oza.5; human. [Q14590-1]
DR CTD; 9310; -.
DR GeneCards; ZNF235; -.
DR HGNC; HGNC:12866; ZNF235.
DR HPA; HPA045582; -.
DR MIM; 604749; gene.
DR neXtProt; NX_Q14590; -.
DR OpenTargets; ENSG00000159917; -.
DR PharmGKB; PA37455; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00840000129740; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q14590; -.
DR KO; K09228; -.
DR OMA; CIFAPYV; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q14590; -.
DR TreeFam; TF350845; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 9310; -.
DR PRO; PR:Q14590; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000159917; -.
DR CleanEx; HS_ZNF235; -.
DR ExpressionAtlas; Q14590; baseline and differential.
DR Genevisible; Q14590; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 16.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 738 Zinc finger protein 235.
FT /FTId=PRO_0000047474.
FT DOMAIN 8 79 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 263 285 C2H2-type 1; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 319 341 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 347 369 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 375 397 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 403 425 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 431 453 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 459 481 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 487 509 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 515 537 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 543 565 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 571 593 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 599 621 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 627 649 C2H2-type 13. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 655 677 C2H2-type 14. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 683 705 C2H2-type 15. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 711 733 C2H2-type 16. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 77 80 Missing (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_022166.
FT VARIANT 296 296 H -> P (in dbSNP:rs2125579).
FT {ECO:0000269|PubMed:15489334}.
FT /FTId=VAR_029806.
FT CONFLICT 123 123 M -> T (in Ref. 4; AAD12728).
FT {ECO:0000305}.
FT CONFLICT 635 635 A -> P (in Ref. 5; CAA55529).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 711 738 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 683 710 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 487 509 ismart:ZnF_C2H2 [T]
FT MYHIT 319 346 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 405 425 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 487 514 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 489 509 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 545 565 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 433 453 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 627 654 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 349 369 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 627 649 ismart:ZnF_C2H2 [T]
FT MYHIT 431 458 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 629 649 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 431 453 ismart:ZnF_C2H2 [T]
FT MYHIT 377 397 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 571 593 ismart:ZnF_C2H2 [T]
FT MYHIT 683 705 ismart:ZnF_C2H2 [T]
FT MYHIT 8 79 iprf:KRAB [T]
FT MYHIT 713 733 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 375 402 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 657 677 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 347 374 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 571 598 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 347 369 ismart:ZnF_C2H2 [T]
FT MYHIT 8 48 ipfam:KRAB [T]
FT MYHIT 459 486 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 321 341 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 599 626 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 403 425 ismart:ZnF_C2H2 [T]
FT MYHIT 459 481 ismart:ZnF_C2H2 [T]
FT MYHIT 263 290 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 461 481 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 543 565 ismart:ZnF_C2H2 [T]
FT MYHIT 601 621 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 543 570 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 515 542 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 403 430 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 517 537 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 711 733 ismart:ZnF_C2H2 [T]
FT MYHIT 599 621 ismart:ZnF_C2H2 [T]
FT MYHIT 573 593 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 655 682 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 685 705 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 655 677 ismart:ZnF_C2H2 [T]
FT MYHIT 8 68 ismart:KRAB [T]
FT MYHIT 375 397 ismart:ZnF_C2H2 [T]
FT MYHIT 319 341 ismart:ZnF_C2H2 [T]
FT MYHIT 263 285 ismart:ZnF_C2H2 [T]
FT MYHIT 515 537 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 738 AA; 83977 MW; 51B301BFF30EB194 CRC64;
MTKFQEAVTF KDVAVAFTEE ELGLLDSAQR KLYRDVMLEN FRNLVSVGHQ SFKPDMISQL
EREEKLWMKE LQTQRGKHSG DRNQNEMATL HKAGLRCFSL GELSCWQIKR HIASKLARSQ
DSMINIEGKS SQFPKHHDSP CQVGAGESIQ ASVDDNCLVN HIGDHSSIIE NQEFPTGKVP
NSWSKIYLNE TQNYQRSCKQ TQMKNKLCIF APYVDIFSCI SHHHDDNIVH KRDKVHSNSD
CGKDTLKVSP LTQRSIHTGQ KTYQGNECEE AFNDSSSLEL HKQVHLGKKS PACSTHEKDT
SYSSGIPVQQ SVRTGKKRYW CHECGKGFSQ SSNLQTHQRV HTGEKPYTCH ECGKSFNQSS
HLYAHLPIHT GEKPYRCDSC GKGFSRSTDL NIHCRVHTGE KPYKCEVCGK GFTQRSHLQA
HERIHTGEKP YKCGDCGKRF SCSSNLHTHQ RVHTEEKPYK CDECGKCFSL SFNLHSHQRV
HTGEKPYKCE ECGKGFSSAS SFQSHQRVHT GEKPFRCNVC GKGFSQSSYF QAHQRVHTGE
KPYKCEVCGK RFNWSLNLHN HQRVHTGEKP YKCEECGKGF SQASNLQAHQ SVHTGEKPFK
CDACQKRFSQ ASHLQAHQRV HTGEKPYKCD TCGKAFSQRS NLQVHQIIHT GEKPFKCEEC
GKEFSWSAGL SAHQRVHTGE KPYTCQQCGK GFSQASHFHT HQRVHTGERP YICDVCCKGF
SQRSHLIYHQ RVHTGGNL
//
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