ID ZN222_HUMAN Reviewed; 451 AA.
AC Q9UK12; G5E9B9; Q8N6G7; Q9P1U5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 30-NOV-2016, entry version 144.
DE RecName: Full=Zinc finger protein 222;
GN Name=ZNF222;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT PHE-58.
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UK12-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UK12-2; Sequence=VSP_046951, VSP_046952;
CC Note=No experimental confirmation available.;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 10 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
DR EMBL; AF187988; AAF04104.1; -; mRNA.
DR EMBL; AC067968; AAF66075.1; -; Genomic_DNA.
DR EMBL; CH471126; EAW57242.1; -; Genomic_DNA.
DR EMBL; BC030261; AAH30261.1; ALT_INIT; mRNA.
DR CCDS; CCDS33045.1; -. [Q9UK12-1]
DR CCDS; CCDS46098.1; -. [Q9UK12-2]
DR PIR; B42177; B42177.
DR RefSeq; NP_001123468.1; NM_001129996.1. [Q9UK12-2]
DR RefSeq; NP_037492.2; NM_013360.2. [Q9UK12-1]
DR UniGene; Hs.279840; -.
DR ProteinModelPortal; Q9UK12; -.
DR SMR; Q9UK12; -.
DR iPTMnet; Q9UK12; -.
DR PhosphoSitePlus; Q9UK12; -.
DR BioMuta; ZNF222; -.
DR DMDM; 116242857; -.
DR PeptideAtlas; Q9UK12; -.
DR PRIDE; Q9UK12; -.
DR Ensembl; ENST00000187879; ENSP00000187879; ENSG00000159885. [Q9UK12-1]
DR Ensembl; ENST00000391960; ENSP00000375822; ENSG00000159885. [Q9UK12-2]
DR GeneID; 7673; -.
DR KEGG; hsa:7673; -.
DR UCSC; uc002oyc.4; human. [Q9UK12-1]
DR CTD; 7673; -.
DR GeneCards; ZNF222; -.
DR HGNC; HGNC:13015; ZNF222.
DR HPA; HPA004086; -.
DR neXtProt; NX_Q9UK12; -.
DR OpenTargets; ENSG00000159885; -.
DR PharmGKB; PA37594; -.
DR GeneTree; ENSGT00840000129740; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q9UK12; -.
DR KO; K09228; -.
DR OMA; CKLHMRE; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q9UK12; -.
DR TreeFam; TF341885; -.
DR BioCyc; ZFISH:ENSG00000159885-MONOMER; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 7673; -.
DR PRO; PR:Q9UK12; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000159885; -.
DR CleanEx; HS_ZNF222; -.
DR ExpressionAtlas; Q9UK12; baseline and differential.
DR Genevisible; Q9UK12; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 11.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 451 Zinc finger protein 222.
FT /FTId=PRO_0000047463.
FT DOMAIN 8 85 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 145 167 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 173 195 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 201 223 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 229 251 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 257 279 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 285 307 C2H2-type 6; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 313 335 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 341 363 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 369 391 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 397 419 C2H2-type 10; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT VAR_SEQ 1 5 MAKLY -> MIDSGEKKPGRRAE (in isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_046951.
FT VAR_SEQ 47 47 V -> VGHQPFHGDTFHFLREEKFWVMGTTSQREGNL (in
FT isoform 2).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_046952.
FT VARIANT 50 50 K -> E (in dbSNP:rs11880330).
FT /FTId=VAR_052796.
FT VARIANT 58 58 V -> F (in dbSNP:rs7258517).
FT {ECO:0000269|PubMed:12743021}.
FT /FTId=VAR_052797.
FT VARIANT 82 82 R -> G (in dbSNP:rs59926292).
FT /FTId=VAR_061940.
FT VARIANT 263 263 G -> D (in dbSNP:rs8112679).
FT /FTId=VAR_052798.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 201 228 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 315 335 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 203 223 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 341 363 ismart:ZnF_C2H2 [T]
FT MYHIT 343 363 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 341 368 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 371 391 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 369 396 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 257 279 ismart:ZnF_C2H2 [T]
FT MYHIT 145 167 ismart:ZnF_C2H2 [T]
FT MYHIT 145 172 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 173 200 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 173 195 ismart:ZnF_C2H2 [T]
FT MYHIT 201 223 ismart:ZnF_C2H2 [T]
FT MYHIT 313 335 ismart:ZnF_C2H2 [T]
FT MYHIT 8 80 iprf:KRAB [T]
FT MYHIT 313 340 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 175 195 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 229 256 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 259 279 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 8 63 ismart:KRAB [T]
FT MYHIT 231 251 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 285 312 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 397 424 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 229 251 ismart:ZnF_C2H2 [T]
FT MYHIT 8 48 ipfam:KRAB [T]
FT MYHIT 257 284 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 147 167 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 369 391 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 451 AA; 52484 MW; A54C0DC566138098 CRC64;
MAKLYEAVTF KDVAVIFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGGK IQTEMETVPE
AGTHEEFSCK QIWEQIASDL TRSQDTTISN SQLFEQDDNP SQIKARLSTV HTREKPFQGE
NCKQFFSDVS FFDLPQQLYS GEKSHTCDEC GKSFCYISAL HIHQRVHMGV KCYKCDVCGK
EFSQSSRLQT HQRVHTGEKP FKCEQCGKGF RCRSALKVHC KLHMREKPYN CEKCGKAFMH
NFQLQKHHRI HTGEKPFKCE ICGKSFCLRS SLNRHCMVHT AEKLYKSEKY GRGFIDRLDL
HKHQMIHMGQ KPYNCKECGK SFKWSSYLLV HQRVHTGEKP YKCEECGKGY ISKSGLDFHH
RTHTGERSYN CDNCGKSFRH ASSILNHKKL HCQRKPLKCE DCGKRLVCRS YCKDQQRDHS
GENPSKCEDC GKRYKRRLNL DIILSLFLND I
//
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