ID ZN200_HUMAN Reviewed; 395 AA.
AC P98182; D3DUB7; D3DUB8; O15361; Q5XKM5; Q7Z5V1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 18-JAN-2017, entry version 147.
DE RecName: Full=Zinc finger protein 200;
GN Name=ZNF200; Synonyms=ZNFMF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9787081; DOI=10.1006/geno.1998.5430;
RA Deng Z., Centola M., Chen X., Sood R., Vedula A., Fischel-Ghodsian N.,
RA Kastner D.L.;
RT "Identification of two Kruppel-related zinc finger genes (ZNF200 and
RT ZNF210) from human chromosome 16p13.3.";
RL Genomics 53:97-103(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RX PubMed=9288094; DOI=10.1038/ng0997-25;
RA Bernot A., Clepet C., Dasilva C., Devaud C., Petit J.-L.,
RA Caloustian C., Cruaud C., Samson D., Pulcini F., Weissenbach J.,
RA Heilig R., Notanicola C., Domingo C., Rozenbaum M., Benchetrit E.,
RA Topaloglu R., Dewalle M., Dross C., Hadjari P., Dupont M.,
RA Demaille J.G., Touitou I., Smaoui N., Nedelec B., Mery J.-P.,
RA Chaabouni H., Delpech M., Grateau G.;
RT "A candidate gene for familial Mediterranean fever.";
RL Nat. Genet. 17:25-31(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Eye, Liver, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could have a role in spermatogenesis.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P98182-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P98182-2; Sequence=VSP_036037;
CC Name=3;
CC IsoId=P98182-3; Sequence=VSP_046734;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis, weakly expressed
CC in spleen, thymus, prostate, ovary, small intestine colon and
CC peripheral blood leukocytes.
CC -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC70008.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
CC Sequence=AAH54005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
DR EMBL; AF060866; AAC70008.1; ALT_INIT; mRNA.
DR EMBL; Y14443; CAA74795.1; -; mRNA.
DR EMBL; AJ003147; CAA05905.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85384.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85385.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85386.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85387.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85388.1; -; Genomic_DNA.
DR EMBL; BC012909; AAH12909.1; -; mRNA.
DR EMBL; BC032575; AAH32575.1; -; mRNA.
DR EMBL; BC054005; AAH54005.1; ALT_INIT; mRNA.
DR CCDS; CCDS10497.1; -. [P98182-1]
DR CCDS; CCDS42112.1; -. [P98182-2]
DR CCDS; CCDS45395.1; -. [P98182-3]
DR RefSeq; NP_001138918.1; NM_001145446.1. [P98182-3]
DR RefSeq; NP_001138919.1; NM_001145447.1. [P98182-3]
DR RefSeq; NP_001138920.1; NM_001145448.1. [P98182-3]
DR RefSeq; NP_003445.2; NM_003454.3. [P98182-1]
DR RefSeq; NP_932353.1; NM_198087.2. [P98182-2]
DR RefSeq; NP_932354.1; NM_198088.2. [P98182-1]
DR RefSeq; XP_005255613.1; XM_005255556.1. [P98182-1]
DR RefSeq; XP_006721003.1; XM_006720940.2. [P98182-1]
DR RefSeq; XP_006721004.1; XM_006720941.2. [P98182-1]
DR RefSeq; XP_016879136.1; XM_017023647.1. [P98182-1]
DR UniGene; Hs.632222; -.
DR ProteinModelPortal; P98182; -.
DR SMR; P98182; -.
DR BioGrid; 113536; 4.
DR IntAct; P98182; 2.
DR MINT; MINT-7969052; -.
DR STRING; 9606.ENSP00000395723; -.
DR iPTMnet; P98182; -.
DR PhosphoSitePlus; P98182; -.
DR BioMuta; ZNF200; -.
DR DMDM; 218511971; -.
DR MaxQB; P98182; -.
DR PaxDb; P98182; -.
DR PeptideAtlas; P98182; -.
DR PRIDE; P98182; -.
DR DNASU; 7752; -.
DR Ensembl; ENST00000396868; ENSP00000380077; ENSG00000010539. [P98182-2]
DR Ensembl; ENST00000396870; ENSP00000380079; ENSG00000010539. [P98182-3]
DR Ensembl; ENST00000396871; ENSP00000380080; ENSG00000010539. [P98182-3]
DR Ensembl; ENST00000414144; ENSP00000405786; ENSG00000010539. [P98182-1]
DR Ensembl; ENST00000431561; ENSP00000395723; ENSG00000010539. [P98182-1]
DR Ensembl; ENST00000575948; ENSP00000458508; ENSG00000010539. [P98182-3]
DR GeneID; 7752; -.
DR KEGG; hsa:7752; -.
DR UCSC; uc002cui.3; human. [P98182-1]
DR CTD; 7752; -.
DR GeneCards; ZNF200; -.
DR HGNC; HGNC:12993; ZNF200.
DR HPA; HPA018981; -.
DR HPA; HPA059310; -.
DR MIM; 603231; gene.
DR neXtProt; NX_P98182; -.
DR OpenTargets; ENSG00000010539; -.
DR PharmGKB; PA37573; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00630000089880; -.
DR HOGENOM; HOG000261602; -.
DR HOVERGEN; HBG059647; -.
DR InParanoid; P98182; -.
DR KO; K09228; -.
DR OMA; RHEGIHV; -.
DR OrthoDB; EOG091G083V; -.
DR PhylomeDB; P98182; -.
DR TreeFam; TF342316; -.
DR BioCyc; ZFISH:ENSG00000010539-MONOMER; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR GenomeRNAi; 7752; -.
DR PRO; PR:P98182; -.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000010539; -.
DR CleanEx; HS_ZNF200; -.
DR ExpressionAtlas; P98182; baseline and differential.
DR Genevisible; P98182; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0044212; F:transcription regulatory region DNA binding; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 5.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Metal-binding; Nucleus;
KW Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 395 Zinc finger protein 200.
FT /FTId=PRO_0000047449.
FT ZN_FING 252 274 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 280 302 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 308 330 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 336 358 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 364 386 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 114 114 Missing (in isoform 2).
FT {ECO:0000303|PubMed:9288094}.
FT /FTId=VSP_036037.
FT VAR_SEQ 156 156 Missing (in isoform 3).
FT {ECO:0000303|PubMed:15489334}.
FT /FTId=VSP_046734.
FT VARIANT 140 140 T -> M (in dbSNP:rs9302870).
FT /FTId=VAR_052790.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 282 302 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 310 330 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 308 330 ismart:ZnF_C2H2 [T]
FT MYHIT 308 335 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 364 391 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 366 386 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 338 358 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 280 307 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 254 274 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 336 363 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 252 279 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 252 274 ismart:ZnF_C2H2 [T]
FT MYHIT 280 302 ismart:ZnF_C2H2 [T]
FT MYHIT 364 386 ismart:ZnF_C2H2 [T]
FT MYHIT 336 358 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 395 AA; 45534 MW; 6E0B8FC5702A159A CRC64;
MMAAKVVPMP PKPKQSFILR VPPDSKLGQD LLRDATNGPK TIHQLVLEHF LTFLPKPSLV
QPSQKVKETL VIMKDVSSSL QNRVHPRPLV KLLPKGVQKE QETVSLYLKA NPEELVVFED
LNVFHCQEEC VSLDPTQQLT SEKEDDSSVG EMMLLAVNGS NPEGEDPERE PVENEDYREK
SSDDDEMDSS LVSQQPPDNQ EKERLNTSIP QKRKMRNLLV TIENDTPLEE LSKYVDISII
ALTRNRRTRR WYTCPLCGKQ FNESSYLISH QRTHTGEKPY DCNHCGKSFN HKTNLNKHER
IHTGEKPYSC SQCGKNFRQN SHRSRHEGIH IREKIFKCPE CGKTFPKNEE FVLHLQSHEA
ERPYGCKKCG RRFGRLSNCT RHEKTHSACK TRKQK
//
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