ID ZN134_HUMAN Reviewed; 427 AA.
AC P52741; Q9Y4B2;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 02-NOV-2016, entry version 134.
DE RecName: Full=Zinc finger protein 134;
GN Name=ZNF134;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding
RT cDNAs identify putative candidate genes for developmental and
RT malignant disorders.";
RL Genomics 27:259-264(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P52741-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P52741-2; Sequence=VSP_035666;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 11 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR EMBL; U09412; AAC50253.1; -; mRNA.
DR EMBL; AK291763; BAF84452.1; -; mRNA.
DR EMBL; AC003682; AAC24610.1; -; Genomic_DNA.
DR EMBL; CH471135; EAW72518.1; -; Genomic_DNA.
DR EMBL; BC112294; AAI12295.1; -; mRNA.
DR EMBL; BC113410; AAI13411.1; -; mRNA.
DR CCDS; CCDS42638.1; -. [P52741-1]
DR PIR; I38599; I38599.
DR RefSeq; NP_003426.3; NM_003435.4. [P52741-1]
DR UniGene; Hs.469694; -.
DR ProteinModelPortal; P52741; -.
DR SMR; P52741; -.
DR STRING; 9606.ENSP00000379464; -.
DR iPTMnet; P52741; -.
DR PhosphoSitePlus; P52741; -.
DR BioMuta; ZNF134; -.
DR DMDM; 212276482; -.
DR EPD; P52741; -.
DR MaxQB; P52741; -.
DR PaxDb; P52741; -.
DR PeptideAtlas; P52741; -.
DR PRIDE; P52741; -.
DR DNASU; 7693; -.
DR Ensembl; ENST00000396161; ENSP00000379464; ENSG00000213762. [P52741-1]
DR GeneID; 7693; -.
DR KEGG; hsa:7693; -.
DR UCSC; uc002qpn.3; human. [P52741-1]
DR CTD; 7693; -.
DR DisGeNET; 7693; -.
DR GeneCards; ZNF134; -.
DR HGNC; HGNC:12918; ZNF134.
DR HPA; HPA009064; -.
DR MIM; 604076; gene.
DR neXtProt; NX_P52741; -.
DR OpenTargets; ENSG00000213762; -.
DR PharmGKB; PA37506; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00760000119107; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; P52741; -.
DR OMA; WTGPGCW; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; P52741; -.
DR TreeFam; TF342033; -.
DR BioCyc; ZFISH:G66-33628-MONOMER; -.
DR GenomeRNAi; 7693; -.
DR PRO; PR:P52741; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000213762; -.
DR CleanEx; HS_ZNF134; -.
DR ExpressionAtlas; P52741; baseline and differential.
DR Genevisible; P52741; HS.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; NAS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 9.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 10.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 427 Zinc finger protein 134.
FT /FTId=PRO_0000047418.
FT ZN_FING 50 72 C2H2-type 1. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 78 100 C2H2-type 2; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 176 198 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 204 226 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 232 254 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 260 282 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 288 310 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 316 338 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 344 366 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 372 394 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 400 422 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VAR_SEQ 1 91 MTLVTAGGAWTGPGCWHEVKDEESSSEQSISIAVSHVNTSK
FT AGLPAQTALPCDICGPILKDILHLDEHQGTHHGLKLHTCGA
FT CGRQFWFSA -> MWGMWETILVQC (in isoform 2).
FT {ECO:0000303|PubMed:7557990}.
FT /FTId=VSP_035666.
FT VARIANT 30 30 I -> T (in dbSNP:rs10414451).
FT /FTId=VAR_052771.
FT VARIANT 46 46 A -> T (in dbSNP:rs10413455).
FT /FTId=VAR_052772.
FT VARIANT 207 207 S -> R (in dbSNP:rs34034473).
FT /FTId=VAR_052773.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 344 366 ismart:ZnF_C2H2 [T]
FT MYHIT 52 73 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 260 282 ismart:ZnF_C2H2 [T]
FT MYHIT 374 394 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 234 254 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 290 310 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 260 287 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 178 198 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 204 231 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 232 254 ismart:ZnF_C2H2 [T]
FT MYHIT 78 105 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 262 282 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 318 338 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 316 338 ismart:ZnF_C2H2 [T]
FT MYHIT 176 203 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 288 315 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 288 310 ismart:ZnF_C2H2 [T]
FT MYHIT 402 422 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 346 366 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 204 226 ismart:ZnF_C2H2 [T]
FT MYHIT 344 371 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 372 399 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 400 422 ismart:ZnF_C2H2 [T]
FT MYHIT 50 72 ismart:ZnF_C2H2 [T]
FT MYHIT 206 226 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 232 259 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 176 198 ismart:ZnF_C2H2 [T]
FT MYHIT 316 343 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 400 427 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 372 394 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 427 AA; 48480 MW; AADF3DD519F12712 CRC64;
MTLVTAGGAW TGPGCWHEVK DEESSSEQSI SIAVSHVNTS KAGLPAQTAL PCDICGPILK
DILHLDEHQG THHGLKLHTC GACGRQFWFS ANLHQYQKCY SIEQPLRRDK SEASIVKNCT
VSKEPHPSEK PFTCKEEQKN FQATLGGCQQ KAIHSKRKTH RSTESGDAFH GEQMHYKCSE
CGKAFSRKDT LVQHQRIHSG EKPYECSECG KAFSRKATLV QHQRIHTGER PYECSECGKT
FSRKDNLTQH KRIHTGEMPY KCNECGKYFS HHSNLIVHQR VHNGARPYKC SDCGKVFRHK
STLVQHESIH TGENPYDCSD CGKSFGHKYT LIKHQRIHTE SKPFECIECG KFFSRSSDYI
AHQRVHTGER PFVCSKCGKD FIRTSHLVRH QRVHTGERPY ECSECGKAYS LSSHLNRHQK
VHTAGRL
//
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