MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Zinc finger protein 100; |
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| MyHits synonyms | ZN100_HUMAN , Q8IYN0 , Q7M4M0 , 9755C6215FC44C87 |
 Legends: 1, VARIANT M -> V (in dbSNP:rs12974842); 2, VARIANT T -> I (in dbSNP:rs7246400). {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:1740334}; 3, KRAB. {ECO:0000255|PROSITE- ProRule:PRU00119}; 4, ZN_FING C2H2-type 1; degenerate. {ECO:0000255|PROSITE-ProRule:PRU00042}; 5, ZN_FING C2H2-type 2. {ECO:0000255|PROSITE- ProRule:PRU00042}; 6, ZN_FING C2H2-type 3. {ECO:0000255|PROSITE- ProRule:PRU00042}; 7, ZN_FING C2H2-type 4. {ECO:0000255|PROSITE- ProRule:PRU00042}; 8, ZN_FING C2H2-type 5. {ECO:0000255|PROSITE- ProRule:PRU00042}; 9, ZN_FING C2H2-type 6. {ECO:0000255|PROSITE- ProRule:PRU00042}; 10, ZN_FING C2H2-type 7. {ECO:0000255|PROSITE- ProRule:PRU00042}; 11, ZN_FING C2H2-type 8. {ECO:0000255|PROSITE- ProRule:PRU00042}; 12, ZN_FING C2H2-type 9. {ECO:0000255|PROSITE- ProRule:PRU00042}; 13, ZN_FING C2H2-type 10. {ECO:0000255|PROSITE- ProRule:PRU00042}; 14, ZN_FING C2H2-type 11. {ECO:0000255|PROSITE- ProRule:PRU00042}; 15, ZN_FING C2H2-type 12. {ECO:0000255|PROSITE- ProRule:PRU00042}; 16, CONFLICT NW -> WN (in Ref. 3; no nucleotide entry). {ECO:0000305}; 17, iprf:ZINC_FINGER_C2H2_2 [T]; 18, ipat:ZINC_FINGER_C2H2_1 [T]; 19, ismart:ZnF_C2H2 [T]; 20, ipfam:KRAB [T]; 21, ismart:KRAB [T].
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ID ZN100_HUMAN Reviewed; 542 AA.
AC Q8IYN0; Q7M4M0;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 30-NOV-2016, entry version 129.
DE RecName: Full=Zinc finger protein 100;
GN Name=ZNF100;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-389.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-437, AND VARIANT ILE-389.
RX PubMed=1740334; DOI=10.1016/0888-7543(92)90372-Y;
RA Hoovers J.M.N., Mannens M., John R., Bliek J., van Heyningen V.,
RA Porteous D.J., Leschot N.J., Westerveld A., Little P.F.R.;
RT "High-resolution localization of 69 potential human zinc finger
RT protein genes: a number are clustered.";
RL Genomics 12:254-263(1992).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00119}.
DR EMBL; AC092364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035579; AAH35579.1; -; mRNA.
DR CCDS; CCDS42538.1; -.
DR PIR; E42075; E42075.
DR RefSeq; NP_775802.2; NM_173531.3.
DR UniGene; Hs.365142; -.
DR ProteinModelPortal; Q8IYN0; -.
DR SMR; Q8IYN0; -.
DR BioGrid; 127858; 4.
DR IntAct; Q8IYN0; 2.
DR STRING; 9606.ENSP00000351042; -.
DR iPTMnet; Q8IYN0; -.
DR PhosphoSitePlus; Q8IYN0; -.
DR BioMuta; ZNF100; -.
DR DMDM; 296453037; -.
DR EPD; Q8IYN0; -.
DR MaxQB; Q8IYN0; -.
DR PaxDb; Q8IYN0; -.
DR PeptideAtlas; Q8IYN0; -.
DR PRIDE; Q8IYN0; -.
DR Ensembl; ENST00000358296; ENSP00000351042; ENSG00000197020.
DR Ensembl; ENST00000614218; ENSP00000483779; ENSG00000274746.
DR GeneID; 163227; -.
DR KEGG; hsa:163227; -.
DR UCSC; uc002nqi.4; human.
DR CTD; 163227; -.
DR GeneCards; ZNF100; -.
DR HGNC; HGNC:12880; ZNF100.
DR HPA; HPA059135; -.
DR MIM; 603982; gene.
DR neXtProt; NX_Q8IYN0; -.
DR OpenTargets; ENSG00000197020; -.
DR OpenTargets; ENSG00000274746; -.
DR PharmGKB; PA37469; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; COG5048; LUCA.
DR GeneTree; ENSGT00790000122969; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8IYN0; -.
DR KO; K09228; -.
DR OMA; CEVHKED; -.
DR OrthoDB; EOG091G02KC; -.
DR PhylomeDB; Q8IYN0; -.
DR TreeFam; TF342117; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR ChiTaRS; ZNF100; human.
DR GenomeRNAi; 163227; -.
DR PRO; PR:Q8IYN0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000197020; -.
DR CleanEx; HS_ZNF100; -.
DR ExpressionAtlas; Q8IYN0; baseline and differential.
DR Genevisible; Q8IYN0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 3.30.160.60; -; 13.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 542 Zinc finger protein 100.
FT /FTId=PRO_0000047405.
FT DOMAIN 35 107 KRAB. {ECO:0000255|PROSITE-
FT ProRule:PRU00119}.
FT ZN_FING 177 199 C2H2-type 1; degenerate.
FT {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT ZN_FING 205 227 C2H2-type 2. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 233 255 C2H2-type 3. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 261 283 C2H2-type 4. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 289 311 C2H2-type 5. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 317 339 C2H2-type 6. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 345 367 C2H2-type 7. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 373 395 C2H2-type 8. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 401 423 C2H2-type 9. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 429 451 C2H2-type 10. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 457 479 C2H2-type 11. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT ZN_FING 485 507 C2H2-type 12. {ECO:0000255|PROSITE-
FT ProRule:PRU00042}.
FT VARIANT 8 8 M -> V (in dbSNP:rs12974842).
FT /FTId=VAR_057395.
FT VARIANT 389 389 T -> I (in dbSNP:rs7246400).
FT {ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:1740334}.
FT /FTId=VAR_060422.
FT CONFLICT 411 412 NW -> WN (in Ref. 3; no nucleotide
FT entry). {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 345 372 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 291 311 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 431 451 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 177 204 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 487 507 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 401 428 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 205 227 ismart:ZnF_C2H2 [T]
FT MYHIT 319 339 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 401 423 ismart:ZnF_C2H2 [T]
FT MYHIT 263 283 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 345 367 ismart:ZnF_C2H2 [T]
FT MYHIT 317 339 ismart:ZnF_C2H2 [T]
FT MYHIT 459 479 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 34 74 ipfam:KRAB [T]
FT MYHIT 373 395 ismart:ZnF_C2H2 [T]
FT MYHIT 485 512 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 373 400 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 289 316 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 429 456 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 233 260 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 261 283 ismart:ZnF_C2H2 [T]
FT MYHIT 35 107 iprf:KRAB [T]
FT MYHIT 347 367 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 457 484 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 317 344 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 375 395 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 233 255 ismart:ZnF_C2H2 [T]
FT MYHIT 205 232 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 35 96 ismart:KRAB [T]
FT MYHIT 207 227 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 289 311 ismart:ZnF_C2H2 [T]
FT MYHIT 485 507 ismart:ZnF_C2H2 [T]
FT MYHIT 457 479 ismart:ZnF_C2H2 [T]
FT MYHIT 235 255 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 403 423 ipat:ZINC_FINGER_C2H2_1 [T]
FT MYHIT 261 288 iprf:ZINC_FINGER_C2H2_2 [T]
FT MYHIT 429 451 ismart:ZnF_C2H2 [T]
SQ SEQUENCE 542 AA; 62745 MW; 9755C6215FC44C87 CRC64;
MDDPRYGMCP LKGASGCPGA ERSLLVQSYF EKGPLTFRDV AIEFSLEEWQ CLDSAQQGLY
RKVMLENYRN LVFLAGIALT KPDLITCLEQ GKEPWNIKRH EMVAKPPVIC SHFPQDLWAE
QDIKDSFQEA ILKKYGKYGH DNLQLQKGCK SVDECKVHKE HDNKLNQCLI TTQSNIFQCD
PSAKVFHTFS NSNRHKIRHT RKKPFKCKKC EKSFCMLLHL TQHKRFHITE NSYQCKDCGK
AFNWFSTLTT HRRIHTGEKP YKCEECGKAF NRSSHLTTHK IIHTGEKPYR CEECGKAFNR
SSHLTTHKRI HTGVKPYKCT ECGKAFNRSS HLTTHRIIHT GEKPYKCEEC GKAFNQSSTL
TTHKITHAGE KPYKCEECGK AFYRFSYLTK HKTSHTGEKF YKCEECGKGF NWSSALTKHK
RIHTGEKPYK CEECGKAFNE SSNLTTHKMI HTGEKPYKCD ECGKAFNRSS QLTAHKMIHT
GEKPYKCEEC GKAFNRSSTL TKHKITHTGE KSYKWEECGK DFNQSLSLIK QNNSYWRETL
QM
//
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