Entry sw:ZDHC4_HUMAN

ID   ZDHC4_HUMAN             Reviewed;         344 AA.
AC   Q9NPG8; A4D2N9; Q53EV7; Q6FIB5; Q9H0R9;
DT   01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   18-JAN-2017, entry version 128.
DE   RecName: Full=Probable palmitoyltransferase ZDHHC4;
DE            EC=2.3.1.225;
DE   AltName: Full=Zinc finger DHHC domain-containing protein 4;
DE            Short=DHHC-4;
DE   AltName: Full=Zinc finger protein 374;
GN   Name=ZDHHC4; Synonyms=ZNF374; ORFNames=DC1, UNQ5787/PRO19576;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Dendritic cell;
RA   Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.;
RT   "Novel genes expressed in human dendritic cells.";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fetal brain;
RX   PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA   Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA   Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA   Wambutt R., Korn B., Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and
RT   analysis of 500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-53.
RC   TISSUE=Testis;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA   Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA   Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA   Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA   Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA   Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA   Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA   Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA   Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA   Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA   Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA   Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA   Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA   Mural R.J., Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [11]
RP   VARIANT [LARGE SCALE ANALYSIS] SER-104.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- CATALYTIC ACTIVITY: Palmitoyl-CoA + [protein]-L-cysteine =
CC       [protein]-S-palmitoyl-L-cysteine + CoA.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 DHHC domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00067}.
DR   EMBL; AF201931; AAF86867.1; -; mRNA.
DR   EMBL; AL136674; CAB66609.1; -; mRNA.
DR   EMBL; AY359090; AAQ89448.1; -; mRNA.
DR   EMBL; CR533511; CAG38542.1; -; mRNA.
DR   EMBL; AK001341; BAA91636.1; -; mRNA.
DR   EMBL; AK223532; BAD97252.1; -; mRNA.
DR   EMBL; AC079742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236963; EAL23725.1; -; Genomic_DNA.
DR   EMBL; CH878731; EAW55023.1; -; Genomic_DNA.
DR   EMBL; BC001239; AAH01239.1; -; mRNA.
DR   CCDS; CCDS5352.1; -.
DR   RefSeq; NP_001127859.1; NM_001134387.1.
DR   RefSeq; NP_001127860.1; NM_001134388.1.
DR   RefSeq; NP_001127861.1; NM_001134389.1.
DR   RefSeq; NP_060576.1; NM_018106.3.
DR   RefSeq; XP_005249850.1; XM_005249793.2.
DR   RefSeq; XP_005249851.1; XM_005249794.3.
DR   RefSeq; XP_005249852.1; XM_005249795.2.
DR   RefSeq; XP_005249853.1; XM_005249796.3.
DR   UniGene; Hs.5268; -.
DR   ProteinModelPortal; Q9NPG8; -.
DR   MINT; MINT-1208911; -.
DR   STRING; 9606.ENSP00000337475; -.
DR   iPTMnet; Q9NPG8; -.
DR   PhosphoSitePlus; Q9NPG8; -.
DR   BioMuta; ZDHHC4; -.
DR   DMDM; 28202108; -.
DR   EPD; Q9NPG8; -.
DR   MaxQB; Q9NPG8; -.
DR   PaxDb; Q9NPG8; -.
DR   PeptideAtlas; Q9NPG8; -.
DR   PRIDE; Q9NPG8; -.
DR   DNASU; 55146; -.
DR   Ensembl; ENST00000335965; ENSP00000337475; ENSG00000136247.
DR   Ensembl; ENST00000396706; ENSP00000379934; ENSG00000136247.
DR   Ensembl; ENST00000396707; ENSP00000379935; ENSG00000136247.
DR   Ensembl; ENST00000396709; ENSP00000379937; ENSG00000136247.
DR   Ensembl; ENST00000396713; ENSP00000379941; ENSG00000136247.
DR   Ensembl; ENST00000405731; ENSP00000385027; ENSG00000136247.
DR   GeneID; 55146; -.
DR   KEGG; hsa:55146; -.
DR   UCSC; uc003sqh.4; human.
DR   CTD; 55146; -.
DR   GeneCards; ZDHHC4; -.
DR   HGNC; HGNC:18471; ZDHHC4.
DR   HPA; HPA032124; -.
DR   HPA; HPA064358; -.
DR   neXtProt; NX_Q9NPG8; -.
DR   OpenTargets; ENSG00000136247; -.
DR   PharmGKB; PA38337; -.
DR   eggNOG; KOG1312; Eukaryota.
DR   eggNOG; COG5273; LUCA.
DR   GeneTree; ENSGT00860000133803; -.
DR   HOGENOM; HOG000253024; -.
DR   HOVERGEN; HBG054775; -.
DR   InParanoid; Q9NPG8; -.
DR   KO; K20003; -.
DR   OMA; GAWNIRY; -.
DR   OrthoDB; EOG091G0BJJ; -.
DR   PhylomeDB; Q9NPG8; -.
DR   TreeFam; TF330931; -.
DR   BioCyc; ZFISH:ENSG00000136247-MONOMER; -.
DR   BRENDA; 2.3.1.225; 2681.
DR   ChiTaRS; ZDHHC4; human.
DR   GeneWiki; ZDHHC4; -.
DR   GenomeRNAi; 55146; -.
DR   PRO; PR:Q9NPG8; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000136247; -.
DR   CleanEx; HS_ZDHHC4; -.
DR   ExpressionAtlas; Q9NPG8; baseline and differential.
DR   Genevisible; Q9NPG8; HS.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   Pfam; PF01529; zf-DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Complete proteome; Lipoprotein; Membrane; Palmitate;
KW   Polymorphism; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    344       Probable palmitoyltransferase ZDHHC4.
FT                                /FTId=PRO_0000212865.
FT   TRANSMEM      3     23       Helical. {ECO:0000255}.
FT   TRANSMEM     68     88       Helical. {ECO:0000255}.
FT   TRANSMEM    100    120       Helical. {ECO:0000255}.
FT   TRANSMEM    193    213       Helical. {ECO:0000255}.
FT   TRANSMEM    256    276       Helical. {ECO:0000255}.
FT   DOMAIN      149    199       DHHC. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00067}.
FT   ACT_SITE    179    179       S-palmitoyl cysteine intermediate.
FT                                {ECO:0000250}.
FT   VARIANT      53     53       V -> M (in dbSNP:rs11559146).
FT                                {ECO:0000269|Ref.6}.
FT                                /FTId=VAR_023832.
FT   VARIANT     104    104       P -> S (in a breast cancer sample;
FT                                somatic mutation).
FT                                {ECO:0000269|PubMed:16959974}.
FT                                /FTId=VAR_036260.
FT   CONFLICT     33     33       L -> P (in Ref. 6; BAD97252).
FT                                {ECO:0000305}.
FT   CONFLICT    244    244       F -> I (in Ref. 2; CAB66609 and 4;
FT                                CAG38542). {ECO:0000305}.
FT   CONFLICT    276    276       F -> S (in Ref. 2; CAB66609 and 4;
FT                                CAG38542). {ECO:0000305}.
FT   CONFLICT    294    294       D -> V (in Ref. 2; CAB66609 and 4;
FT                                CAG38542). {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       150    292       ipfam:DHHC [T]
SQ   SEQUENCE   344 AA;  39787 MW;  3D2CF22B14036908 CRC64;
     MDFLVLFLFY LASVLMGLVL ICVCSKTHSL KGLARGGAQI FSCIIPECLQ RAVHGLLHYL
     FHTRNHTFIV LHLVLQGMVY TEYTWEVFGY CQELELSLHY LLLPYLLLGV NLFFFTLTCG
     TNPGIITKAN ELLFLHVYEF DEVMFPKNVR CSTCDLRKPA RSKHCSVCNW CVHRFDHHCV
     WVNNCIGAWN IRYFLIYVLT LTASAATVAI VSTTFLVHLV VMSDLYQETY IDDLGHLHVM
     DTVFLIQYLF LTFPRIVFML GFVVVLSFLL GGYLLFVLYL AATNQTTNEW YRGDWAWCQR
     CPLVAWPPSA EPQVHRNIHS HGLRSNLQEI FLPAFPCHER KKQE
//