Entry sw:ZBT22_CANLF

ID   ZBT22_CANLF             Reviewed;         640 AA.
AC   Q5TJE2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   30-NOV-2016, entry version 72.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 22;
DE   AltName: Full=Zinc finger protein 297;
GN   Name=ZBTB22; Synonyms=ZNF297;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Doberman pinscher;
RX   PubMed=15607421; DOI=10.1016/j.ygeno.2004.09.009;
RA   Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A.,
RA   Ollier W.E.R., Binns M.M.;
RT   "Genomic sequence of the class II region of the canine MHC: comparison
RT   with the MHC of other mammalian species.";
RL   Genomics 85:48-59(2005).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 BTB (POZ) domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00037}.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
DR   EMBL; AJ630366; CAI11446.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q5TJE2; -.
DR   STRING; 9615.ENSCAFP00000001388; -.
DR   PaxDb; Q5TJE2; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   HOGENOM; HOG000231975; -.
DR   HOVERGEN; HBG056510; -.
DR   InParanoid; Q5TJE2; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 3.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ.
DR   InterPro; IPR029833; ZBT22/43.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   PANTHER; PTHR24414:SF4; PTHR24414:SF4; 3.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    640       Zinc finger and BTB domain-containing
FT                                protein 22.
FT                                /FTId=PRO_0000047516.
FT   DOMAIN       57    121       BTB. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00037}.
FT   ZN_FING     490    511       C2H2-type 1; atypical.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   ZN_FING     517    539       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     545    571       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   MOD_RES     203    203       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:O15209}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       490    516       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT       519    539       ipat:ZINC_FINGER_C2H2_1 [T]
FT   MYHIT        47    149       ipfam:BTB [T]
FT   MYHIT       545    566       ismart:ZnF_C2H2 [T]
FT   MYHIT       517    539       ismart:ZnF_C2H2 [T]
FT   MYHIT        57    151       ismart:BTB [T]
FT   MYHIT       517    544       iprf:ZINC_FINGER_C2H2_2 [T]
FT   MYHIT        57    121       iprf:BTB [T]
FT   MYHIT       490    511       ismart:ZnF_C2H2 [T]
SQ   SEQUENCE   640 AA;  65998 MW;  2495A2A4C851E607 CRC64;
     MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS
     IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA
     AADIVNFLTV GSVLQMWHIV DKCTELLREG RASATTTTIT PAAATSATVP GAGVPSGSGA
     TVVPATVGSV RSHASSRASE NQSPSSSNYF SPRESTDFSS SSQEAFPASA VGSGERRGGG
     PVFPAPVVGS GGATSGKLLL EADELCHDGG DERGPVVPGA GLRRPTYAPP SIMPQKHWVY
     VKRGGNSPAP APLVPQDPDL EEDEEEDLVL TCEDDEDEEL GGGSRVPEAG GREATLSISD
     VRTLTEPPDK GEEQVNFCES SNDFGSYDGG GPGAGLDDSG GPTPSSYAPS HPPRPLLPLD
     MQGNQILVFP SSSSSSSSSS SSQAPGQPPG NQAEHGAVTL GGTSSGALGM PGGPGGTPGG
     TGSGDGNKIF LCHCGKAFSH KSMRDRHVNM HLNLRPFDCP VCNKKFKMKH HLTEHMKTHT
     GLKPYECGVC AKKFMWRDSF MRHRGHCERR HRLVGGGGGG GPGPGGPTGP TLPLKRESPG
     AGGGSGDEAS GATPQSSRRV WSPPSVHKVE MGFGGGGGTN
//