ID WALR_STAAR Reviewed; 233 AA.
AC Q6GKS7;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 02-NOV-2016, entry version 95.
DE RecName: Full=Transcriptional regulatory protein WalR {ECO:0000305};
GN Name=walR; Synonyms=yycF; OrderedLocusNames=SAR0018;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T.,
RA Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L.,
RA Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K.,
RA James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K.,
RA Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M.,
RA Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G.,
RA Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains:
RT evidence for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Member of the two-component regulatory system WalK/WalR
CC that regulates genes involved in autolysis, biofilm formation and
CC cell wall metabolism. {ECO:0000250|UniProtKB:Q2G2U6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by WalK. {ECO:0000250|UniProtKB:Q2G2U6}.
CC -!- SIMILARITY: Contains 1 OmpR/PhoB-type DNA-binding domain.
CC {ECO:0000255|PROSITE-ProRule:PRU01091}.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00169}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG39046.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR EMBL; BX571856; CAG39046.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000101976.1; NC_002952.2.
DR ProteinModelPortal; Q6GKS7; -.
DR SMR; Q6GKS7; -.
DR EnsemblBacteria; CAG39046; CAG39046; SAR0018.
DR GeneID; 28379619; -.
DR KEGG; sar:SAR0018; -.
DR PATRIC; 19543532; VBIStaAur71814_0018.
DR HOGENOM; HOG000034819; -.
DR KO; K07668; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1 233 Transcriptional regulatory protein WalR.
FT /FTId=PRO_0000353036.
FT DOMAIN 4 117 Response regulatory.
FT {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT DNA_BIND 132 231 OmpR/PhoB-type. {ECO:0000255|PROSITE-
FT ProRule:PRU01091}.
FT MOD_RES 53 53 4-aspartylphosphate.
FT {ECO:0000255|PROSITE-ProRule:PRU00169}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 153 229 ipfam:Trans_reg_C [T]
FT MYHIT 3 113 ismart:REC [T]
FT MYHIT 132 231 iprf:OMPR_PHOB [T]
FT MYHIT 5 114 ipfam:Response_reg [T]
FT MYHIT 153 229 ismart:Trans_reg_C [T]
FT MYHIT 4 117 iprf:RESPONSE_REGULATORY [T]
SQ SEQUENCE 233 AA; 27192 MW; BFA71D9C2464F600 CRC64;
MARKVVVVDD EKPIADILEF NLKKEGYDVY CAYDGNDAVD LIYEEEPDIV LLDIMLPGRD
GMEVCREVRK KYEMPIIMLT AKDSEIDKVL GLELGADDYV TKPFSTRELI ARVKANLRRH
YSQPAQDTGN VTNEITIKDI VIYPDAYSIK KRGEDIELTH REFELFHYLS KHMGQVMTRE
HLLQTVWGYD YFGDVRTVDV TIRRLREKIE DDPSHPEYIV TRRGVGYFLQ QHE
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