ID WALR_STAA3 Reviewed; 233 AA.
AC Q2FKN8;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 02-NOV-2016, entry version 75.
DE RecName: Full=Transcriptional regulatory protein WalR {ECO:0000305};
GN Name=walR; OrderedLocusNames=SAUSA300_0020;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/S0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- FUNCTION: Member of the two-component regulatory system WalK/WalR
CC that regulates genes involved in autolysis, biofilm formation and
CC cell wall metabolism. {ECO:0000250|UniProtKB:Q2G2U6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by WalK. {ECO:0000250|UniProtKB:Q2G2U6}.
CC -!- SIMILARITY: Contains 1 OmpR/PhoB-type DNA-binding domain.
CC {ECO:0000255|PROSITE-ProRule:PRU01091}.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
CC {ECO:0000255|PROSITE-ProRule:PRU00169}.
DR EMBL; CP000255; ABD20798.1; -; Genomic_DNA.
DR ProteinModelPortal; Q2FKN8; -.
DR SMR; Q2FKN8; -.
DR EnsemblBacteria; ABD20798; ABD20798; SAUSA300_0020.
DR KEGG; saa:SAUSA300_0020; -.
DR PATRIC; 19589248; VBIStaAur129981_0065.
DR HOGENOM; HOG000034819; -.
DR KO; K07668; -.
DR OMA; FHYLANH; -.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 233 Transcriptional regulatory protein WalR.
FT /FTId=PRO_0000353045.
FT DOMAIN 4 117 Response regulatory.
FT {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT DNA_BIND 132 231 OmpR/PhoB-type. {ECO:0000255|PROSITE-
FT ProRule:PRU01091}.
FT MOD_RES 53 53 4-aspartylphosphate.
FT {ECO:0000255|PROSITE-ProRule:PRU00169}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 4 117 iprf:RESPONSE_REGULATORY [T]
FT MYHIT 153 229 ipfam:Trans_reg_C [T]
FT MYHIT 5 114 ipfam:Response_reg [T]
FT MYHIT 132 231 iprf:OMPR_PHOB [T]
FT MYHIT 153 229 ismart:Trans_reg_C [T]
FT MYHIT 3 113 ismart:REC [T]
SQ SEQUENCE 233 AA; 27192 MW; BFA71D9C2464F600 CRC64;
MARKVVVVDD EKPIADILEF NLKKEGYDVY CAYDGNDAVD LIYEEEPDIV LLDIMLPGRD
GMEVCREVRK KYEMPIIMLT AKDSEIDKVL GLELGADDYV TKPFSTRELI ARVKANLRRH
YSQPAQDTGN VTNEITIKDI VIYPDAYSIK KRGEDIELTH REFELFHYLS KHMGQVMTRE
HLLQTVWGYD YFGDVRTVDV TIRRLREKIE DDPSHPEYIV TRRGVGYFLQ QHE
//
|
