Legends: 1, CHAIN Ubiquinol-cytochrome-c reductase complex assembly factor 3; 2, TOPO_DOM Mitochondrial matrix. {ECO:0000250|UniProtKB:Q6UW78}; 3, TRANSMEM Helical. {ECO:0000255}; 4, TOPO_DOM Mitochondrial intermembrane. {ECO:0000250|UniProtKB:Q6UW78}; 5, REGION Mediates lipid-binding. {ECO:0000250|UniProtKB:Q6UW78}; 6, COMPBIAS Poly-Gly.
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ID UQCC3_BOVIN Reviewed; 95 AA.
AC Q148G8;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 07-SEP-2016, entry version 53.
DE RecName: Full=Ubiquinol-cytochrome-c reductase complex assembly factor 3 {ECO:0000250|UniProtKB:Q6UW78};
GN Name=UQCC3 {ECO:0000250|UniProtKB:Q6UW78};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC Pecora; Bovidae; Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the assembly of the ubiquinol-cytochrome c
CC reductase complex (mitochondrial respiratory chain complex III or
CC cytochrome b-c1 complex), mediating cytochrome b recruitment and
CC probably stabilization within the complex. Thereby, plays an
CC important role in ATP production by mitochondria. Cardiolipin-
CC binding protein, it may also control the cardiolipin composition
CC of mitochondria membranes and their morphology.
CC {ECO:0000250|UniProtKB:Q6UW78}.
CC -!- SUBUNIT: Associates with the ubiquinol-cytochrome c reductase
CC complex (mitochondrial respiratory chain complex III or cytochrome
CC b-c1 complex). {ECO:0000250|UniProtKB:Q6UW78}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q6UW78}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q6UW78}.
CC -!- PTM: Probably cleaved by OMA1 under mitochondrial stress
CC conditions. {ECO:0000250|UniProtKB:Q6UW78}.
CC -!- SIMILARITY: Belongs to the UQCC3 family. {ECO:0000305}.
DR EMBL; BC118350; AAI18351.1; -; mRNA.
DR RefSeq; NP_001069182.1; NM_001075714.2.
DR UniGene; Bt.3318; -.
DR PaxDb; Q148G8; -.
DR PRIDE; Q148G8; -.
DR Ensembl; ENSBTAT00000013832; ENSBTAP00000013832; ENSBTAG00000010470.
DR GeneID; 515452; -.
DR KEGG; bta:515452; -.
DR CTD; 790955; -.
DR eggNOG; ENOG410J2F0; Eukaryota.
DR eggNOG; ENOG41118KV; LUCA.
DR GeneTree; ENSGT00390000001930; -.
DR HOGENOM; HOG000111740; -.
DR InParanoid; Q148G8; -.
DR OMA; QAMLKEM; -.
DR TreeFam; TF339744; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000010470; -.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005750; C:mitochondrial respiratory chain complex III; IEA:Ensembl.
DR GO; GO:1901612; F:cardiolipin binding; ISS:UniProtKB.
DR GO; GO:0070300; F:phosphatidic acid binding; ISS:UniProtKB.
DR GO; GO:0006754; P:ATP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; ISS:UniProtKB.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR InterPro; IPR027896; DUF4574.
DR Pfam; PF15141; DUF4574; 1.
PE 3: Inferred from homology;
KW ATP synthesis; Complete proteome; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 95 Ubiquinol-cytochrome-c reductase complex
FT assembly factor 3.
FT /FTId=PRO_0000351680.
FT TOPO_DOM 1 7 Mitochondrial matrix.
FT {ECO:0000250|UniProtKB:Q6UW78}.
FT TRANSMEM 8 28 Helical. {ECO:0000255}.
FT TOPO_DOM 29 95 Mitochondrial intermembrane.
FT {ECO:0000250|UniProtKB:Q6UW78}.
FT REGION 23 80 Mediates lipid-binding.
FT {ECO:0000250|UniProtKB:Q6UW78}.
FT COMPBIAS 83 92 Poly-Gly.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 83 ipfam:DUF4574 [T]
SQ SEQUENCE 95 AA; 9925 MW; 92396A693460FE2B CRC64;
MTTLRKLLLV GALLGAGAGV GTALFALVTP GEERKQAMLK EMPEQYPQRR DEAARTKELL
LATLQEAAAT QENVAWRKNW MSGGGGGGGG GGRSA
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