ID UDG_STRP8 Reviewed; 402 AA.
AC Q8NKX0;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 02-NOV-2016, entry version 92.
DE RecName: Full=UDP-glucose 6-dehydrogenase;
DE Short=UDP-Glc dehydrogenase;
DE Short=UDP-GlcDH;
DE Short=UDPGDH;
DE EC=1.1.1.22;
GN Name=hasB; OrderedLocusNames=spyM18_2237;
OS Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=186103;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS8232;
RX PubMed=11917108; DOI=10.1073/pnas.062526099;
RA Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F.,
RA Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q.,
RA Kapur V., Daly J.A., Veasy L.G., Musser J.M.;
RT "Genome sequence and comparative microarray analysis of serotype M18
RT group A Streptococcus strains associated with acute rheumatic fever
RT outbreaks.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC -!- FUNCTION: Catalyzes the formation of UDP-glucuronic acid which is
CC required for capsular hyaluronic acid synthesis. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY: UDP-glucose + 2 NAD(+) + H(2)O = UDP-
CC glucuronate + 2 NADH.
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate
CC biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose:
CC step 1/1.
CC -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC family. {ECO:0000305}.
DR EMBL; AE009949; AAL98668.1; -; Genomic_DNA.
DR PIR; A46089; A46089.
DR RefSeq; WP_011018341.1; NC_003485.1.
DR ProteinModelPortal; Q8NKX0; -.
DR SMR; Q8NKX0; -.
DR EnsemblBacteria; AAL98668; AAL98668; spyM18_2237.
DR KEGG; spm:spyM18_2237; -.
DR PATRIC; 19750855; VBIStrPyo4396_1991.
DR HOGENOM; HOG000280378; -.
DR KO; K00012; -.
DR OMA; FQSADFV; -.
DR UniPathway; UPA00038; UER00491.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0006065; P:UDP-glucuronate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.1040.10; -; 1.
DR Gene3D; 3.40.50.720; -; 2.
DR InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR InterPro; IPR013328; 6PGD_dom_2.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR017476; UDP-Glc/GDP-Man.
DR InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR InterPro; IPR028357; UDPglc_DH_bac.
DR PANTHER; PTHR11374; PTHR11374; 1.
DR Pfam; PF00984; UDPG_MGDP_dh; 1.
DR Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR SUPFAM; SSF48179; SSF48179; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR SUPFAM; SSF52413; SSF52413; 1.
DR TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE 3: Inferred from homology;
KW Capsule biogenesis/degradation; NAD; Oxidoreductase.
FT CHAIN 1 402 UDP-glucose 6-dehydrogenase.
FT /FTId=PRO_0000074058.
FT NP_BIND 2 19 NAD. {ECO:0000255}.
FT ACT_SITE 260 260 {ECO:0000250}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 167 ipfam:UDPG_MGDP_dh_N [T]
FT MYHIT 314 390 ipfam:UDPG_MGDP_dh_C [T]
FT MYHIT 313 401 ismart:UDPG_MGDP_dh_C [T]
FT MYHIT 199 288 ipfam:UDPG_MGDP_dh [T]
SQ SEQUENCE 402 AA; 45483 MW; DD1869D659F4CA58 CRC64;
MKIAVAGSGY VGLSLGVLLS LQNEVTIVDI LPSKVDKINN GLSPIQDEYI EYYLKSKQLS
IKATLDSKAA YKEAELVIIA TPTNYNSRIN YFDTQHVETV IKEVLSVNSH ATLIIKSTIP
IGFITEMRQK FQTDRIIFSP EFLRESKALY DNLYPSRIIV SCEENDSPKV KADAEKFALL
LKSAAKKNNV PVLIMGASEA EAVKLFANTY LALRVAYFNE LDTYAESRKL NSHMIIQGIS
YDDRIGMHYN NPSFGYGGYC LPKDTKQLLA NYNNIPQTLI EAIVSSNNVR KSYIAKQIIN
VLKEQESPVK VVGVYRLIMK SNSDNFRESA IKDVIDILKS KDIKIIIYEP MLNKLESEDQ
SVLVNDLENF KKQANIIVTN RYDNELQDVK NKVYSRDIFG RD
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