MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Probable efflux pump periplasmic linker TtgA; Flags: Precursor; |
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| MyHits synonyms | TTGA_PSEPK , Q88N30 , 16BB3FA87E3C16CA |
 Legends: 1, N-palmitoyl cysteine. {ECO:0000255|PROSITE-ProRule:PRU00303}; 2, S-diacylglycerol cysteine. {ECO:0000255|PROSITE-ProRule:PRU00303}; 3, SIGNAL {ECO:0000255|PROSITE-ProRule:PRU00303}; 4, COILED {ECO:0000255}.
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ID TTGA_PSEPK Reviewed; 384 AA.
AC Q88N30;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 02-NOV-2016, entry version 80.
DE RecName: Full=Probable efflux pump periplasmic linker TtgA;
DE Flags: Precursor;
GN Name=ttgA; OrderedLocusNames=PP_1386;
OS Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 /
OS KT2440).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=160488;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440;
RX PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M.,
RA Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K.,
RA Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D.,
RA Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S.,
RA Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B.,
RA Fraser C.M.;
RT "Complete genome sequence and comparative analysis of the
RT metabolically versatile Pseudomonas putida KT2440.";
RL Environ. Microbiol. 4:799-808(2002).
RN [2]
RP CHARACTERIZATION.
RX PubMed=12743835; DOI=10.1007/s00792-003-0331-x;
RA Segura A., Rojas A., Hurtado A., Huertas M.J., Ramos J.L.;
RT "Comparative genomic analysis of solvent extrusion pumps in
RT Pseudomonas strains exhibiting different degrees of solvent
RT tolerance.";
RL Extremophiles 7:371-376(2003).
CC -!- FUNCTION: Probable periplasmic linker protein component of the
CC TtgABC efflux pump with unknown specificity.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-
CC anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP)
CC (TC 8.A.1) family. {ECO:0000305}.
CC -!- CAUTION: There are 4 nearly identical operons in various strains
CC of P.putida. The ttgABC operon of strain DOT-T1E and the mepABC
CC operon of strain KT2442-TOL function in solvent and antibiotic
CC efflux; however in strain S12 the arpABC operon functions only in
CC antibiotic efflux. This may be due to different protein expression
CC levels. In KT2400 this operon does not seem to function in toluene
CC efflux. {ECO:0000305}.
DR EMBL; AE015451; AAN67009.1; -; Genomic_DNA.
DR RefSeq; NP_743545.1; NC_002947.4.
DR RefSeq; WP_010952494.1; NC_002947.4.
DR ProteinModelPortal; Q88N30; -.
DR STRING; 160488.PP_1386; -.
DR GeneID; 1041938; -.
DR KEGG; ppu:PP_1386; -.
DR PATRIC; 19940983; VBIPsePut30601_1470.
DR eggNOG; ENOG4105C1P; Bacteria.
DR eggNOG; ENOG410XNVN; LUCA.
DR HOGENOM; HOG000158247; -.
DR KO; K03585; -.
DR OMA; QEYDDAN; -.
DR Proteomes; UP000000556; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR Pfam; PF00529; HlyD; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR TIGRFAMs; TIGR01730; RND_mfp; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Coiled coil; Complete proteome;
KW Lipoprotein; Membrane; Palmitate; Reference proteome; Signal;
KW Transport.
FT SIGNAL 1 22 {ECO:0000255|PROSITE-ProRule:PRU00303}.
FT CHAIN 23 384 Probable efflux pump periplasmic linker
FT TtgA.
FT /FTId=PRO_0000018717.
FT COILED 115 155 {ECO:0000255}.
FT LIPID 23 23 N-palmitoyl cysteine.
FT {ECO:0000255|PROSITE-ProRule:PRU00303}.
FT LIPID 23 23 S-diacylglycerol cysteine.
FT {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 34 344 ipfam:HlyD [T]
FT MYHIT 60 277 ipfam:HlyD_D23 [T]
SQ SEQUENCE 384 AA; 41250 MW; 16BB3FA87E3C16CA CRC64;
MQFKPAVTAL VSAVALATLL SGCKKEEAAP AAQAPQVGVV TIQPQAFTLT SELPGRTSAY
RVAEVRPQVN GIILKRLFKE GSEVKEGQQL YQIDPAVYEA TLANAKANLL ATRSLAERYK
QLIDEQAVSK QEYDDANAKR LQAEASLKSA QIDLRYTKVL APISGRIGRS SFTEGALVSN
GQTDAMATIQ QLDPIYVDVT QSTAELLKLR RDLESGQLQK AGDNAASVQL VLEDGSLFKQ
EGRLEFSEVA VDETTGSVTL RALFPNPDHT LLPGMFVHAR LKAGVNANAI LAPQQGVTRD
LKGAPTALVV NQENKVELRQ LKASRTLGSD WLIEEGLNPG DRLITEGLQY VRPGVEVKVS
DATNVKKPAG PDQANAAKAD AKAE
//
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