MyHits has reached its end of life and no longer provides data or services. Thank you for your support and trust for more than 23 years!
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
However, the webserver will remain online in its present form at least until end of March 2025.
To ensure the future of MyHits, we would be happy if a person or community would take over the resource or parts of it. Interested? Please contact us (myhits [at] sib.swiss).
Pagni M, Ioannidis V, Cerutti L, Zahn-Zabal M, Jongeneel CV, Hau J, Martin O, Kuznetsov D, Falquet L.
MyHits: improvements to an interactive resource for analyzing protein sequences.
Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W433-7
- MyHits
| Description | RecName: Full=Tryptophan synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00131}; EC=4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131}; |
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| MyHits synonyms | TRPA_CALBD , B9MKC6 , E072C87F884A9E14 |
 Legends: 1, ACT_SITE Proton acceptor. {ECO:0000255|HAMAP- Rule:MF_00131}; 2, ipat:TRP_SYNTHASE_ALPHA [T].
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ID TRPA_CALBD Reviewed; 256 AA.
AC B9MKC6;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 02-NOV-2016, entry version 48.
DE RecName: Full=Tryptophan synthase alpha chain {ECO:0000255|HAMAP-Rule:MF_00131};
DE EC=4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131};
GN Name=trpA {ECO:0000255|HAMAP-Rule:MF_00131};
GN OrderedLocusNames=Athe_1690;
OS Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)
OS (Anaerocellum thermophilum).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacterales Family III. Incertae Sedis;
OC Caldicellulosiruptor.
OX NCBI_TaxID=521460;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1888 / DSM 6725 / Z-1320;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T.,
RA Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Ovchinnikova G., Kataeva I., Adams M.W.W.;
RT "Complete sequence of chromosome of Anaerocellum thermophilum DSM
RT 6725.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The alpha subunit is responsible for the aldol cleavage
CC of indoleglycerol phosphate to indole and glyceraldehyde 3-
CC phosphate. {ECO:0000255|HAMAP-Rule:MF_00131}.
CC -!- CATALYTIC ACTIVITY: L-serine + 1-C-(indol-3-yl)glycerol 3-
CC phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O.
CC {ECO:0000255|HAMAP-Rule:MF_00131}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 5/5. {ECO:0000255|HAMAP-
CC Rule:MF_00131}.
CC -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC {ECO:0000255|HAMAP-Rule:MF_00131}.
CC -!- SIMILARITY: Belongs to the TrpA family. {ECO:0000255|HAMAP-
CC Rule:MF_00131}.
DR EMBL; CP001393; ACM60784.1; -; Genomic_DNA.
DR RefSeq; WP_015908114.1; NC_012034.1.
DR ProteinModelPortal; B9MKC6; -.
DR STRING; 521460.Athe_1690; -.
DR PRIDE; B9MKC6; -.
DR EnsemblBacteria; ACM60784; ACM60784; Athe_1690.
DR KEGG; ate:Athe_1690; -.
DR PATRIC; 20900548; VBIAnaThe135187_1775.
DR eggNOG; ENOG4105F6H; Bacteria.
DR eggNOG; COG0159; LUCA.
DR HOGENOM; HOG000223816; -.
DR KO; K01695; -.
DR OMA; PVFICPP; -.
DR OrthoDB; POG091H02IL; -.
DR UniPathway; UPA00035; UER00044.
DR Proteomes; UP000007723; Chromosome.
DR GO; GO:0004834; F:tryptophan synthase activity; IEA:UniProtKB-HAMAP.
DR GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd04724; Tryptophan_synthase_alpha; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00131; Trp_synth_alpha; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR018204; Trp_synthase_alpha_AS.
DR InterPro; IPR002028; Trp_synthase_suA.
DR Pfam; PF00290; Trp_syntA; 1.
DR SUPFAM; SSF51366; SSF51366; 1.
DR TIGRFAMs; TIGR00262; trpA; 1.
DR PROSITE; PS00167; TRP_SYNTHASE_ALPHA; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW Complete proteome; Lyase; Tryptophan biosynthesis.
FT CHAIN 1 256 Tryptophan synthase alpha chain.
FT /FTId=PRO_1000198697.
FT ACT_SITE 48 48 Proton acceptor. {ECO:0000255|HAMAP-
FT Rule:MF_00131}.
FT ACT_SITE 59 59 Proton acceptor. {ECO:0000255|HAMAP-
FT Rule:MF_00131}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 8 252 ipfam:Trp_syntA [T]
FT MYHIT 14 252 ihamap:Trp_synth_alpha [T]
FT MYHIT 47 60 ipat:TRP_SYNTHASE_ALPHA [T]
SQ SEQUENCE 256 AA; 29043 MW; E072C87F884A9E14 CRC64;
MNFIDERFER LKKEGKKAFI GYVTFGYPTF EETLWFIKLV YSYVDILEIG FPFSDPIADG
EIIQKASIKA LSEGVKLSHL FESIEKFKKD KPVVLMLYAN TVYKRGIDRF FESCKACGVD
GVIIPDVSFE ESFEFKEVAE KFGIVYIDLV SISSLERAKM IGRQSRGFLY CVSRKGVTGF
KGQIDDRIFT FLKELKTVTS TPLAVGFGIK SKEDVQKFKD LADGIVIGSA IITKIDEGKD
KLEDFLKEIS ESLKDK
//
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