ID TRI26_HUMAN Reviewed; 539 AA.
AC Q12899; A6NG96; Q5SRL2;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 30-NOV-2016, entry version 160.
DE RecName: Full=Tripartite motif-containing protein 26;
DE AltName: Full=Acid finger protein;
DE Short=AFP;
DE AltName: Full=RING finger protein 95;
DE AltName: Full=Zinc finger protein 173;
GN Name=TRIM26; Synonyms=RNF95, ZNF173;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8530076; DOI=10.1006/geno.1995.1236;
RA Chu T.W., Capossela A., Coleman R., Goei V.L., Nallur G., Gruen J.R.;
RT "Cloning of a new 'finger' protein gene (ZNF173) within the class I
RT region of the human MHC.";
RL Genomics 29:229-239(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina T., Ota M., Katsuyama Y., Hashimoto N., Inoko H.;
RT "Genome diversity in HLA: a new strategy for detection of genetic
RT polymorphisms in expressed genes within the HLA class III and class I
RT regions.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Peripheral blood leukocyte;
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y.,
RA Meyer A., Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K.,
RA Gojobori T., Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q08117:AES; NbExp=3; IntAct=EBI-2341136, EBI-717810;
CC P43360:MAGEA6; NbExp=3; IntAct=EBI-2341136, EBI-1045155;
CC Q9NVV9:THAP1; NbExp=5; IntAct=EBI-2341136, EBI-741515;
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
CC -!- SIMILARITY: Contains 1 B box-type zinc finger.
CC {ECO:0000255|PROSITE-ProRule:PRU00024}.
CC -!- SIMILARITY: Contains 1 B30.2/SPRY domain. {ECO:0000255|PROSITE-
CC ProRule:PRU00548}.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC {ECO:0000255|PROSITE-ProRule:PRU00175}.
DR EMBL; U09825; AAA93131.1; -; mRNA.
DR EMBL; BA000025; BAB63330.1; -; Genomic_DNA.
DR EMBL; AB088090; BAC54923.1; -; Genomic_DNA.
DR EMBL; AB202086; BAE78607.1; -; Genomic_DNA.
DR EMBL; AB103596; BAF31258.1; -; Genomic_DNA.
DR EMBL; AL844220; CAI18614.1; -; Genomic_DNA.
DR EMBL; BX248419; CAM26023.1; -; Genomic_DNA.
DR EMBL; CR788282; CAQ07461.1; -; Genomic_DNA.
DR EMBL; CR388382; CAQ08631.1; -; Genomic_DNA.
DR EMBL; BX927189; CAQ09454.1; -; Genomic_DNA.
DR EMBL; BX927221; CAQ09454.1; JOINED; Genomic_DNA.
DR EMBL; BX927221; CAQ10305.1; -; Genomic_DNA.
DR EMBL; BX927189; CAQ10305.1; JOINED; Genomic_DNA.
DR EMBL; CR759838; CAQ11096.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX03272.1; -; Genomic_DNA.
DR EMBL; BC024039; AAH24039.1; -; mRNA.
DR EMBL; BC032297; AAH32297.1; -; mRNA.
DR CCDS; CCDS4678.1; -.
DR RefSeq; NP_001229712.1; NM_001242783.1.
DR RefSeq; NP_003440.1; NM_003449.4.
DR RefSeq; XP_005249431.1; XM_005249374.2.
DR RefSeq; XP_005249432.1; XM_005249375.2.
DR RefSeq; XP_005249433.1; XM_005249376.2.
DR RefSeq; XP_005249434.1; XM_005249377.2.
DR RefSeq; XP_005249435.1; XM_005249378.2.
DR RefSeq; XP_006715243.1; XM_006715180.2.
DR UniGene; Hs.485041; -.
DR UniGene; Hs.731863; -.
DR ProteinModelPortal; Q12899; -.
DR SMR; Q12899; -.
DR BioGrid; 113515; 67.
DR DIP; DIP-52853N; -.
DR IntAct; Q12899; 46.
DR MINT; MINT-4993084; -.
DR STRING; 9606.ENSP00000391879; -.
DR iPTMnet; Q12899; -.
DR PhosphoSitePlus; Q12899; -.
DR BioMuta; TRIM26; -.
DR DMDM; 17380344; -.
DR EPD; Q12899; -.
DR PaxDb; Q12899; -.
DR PeptideAtlas; Q12899; -.
DR PRIDE; Q12899; -.
DR DNASU; 7726; -.
DR Ensembl; ENST00000327357; ENSP00000331131; ENSG00000137313.
DR Ensembl; ENST00000383607; ENSP00000373102; ENSG00000137313.
DR Ensembl; ENST00000396558; ENSP00000379806; ENSG00000137313.
DR Ensembl; ENST00000415923; ENSP00000415755; ENSG00000231002.
DR Ensembl; ENST00000422349; ENSP00000396188; ENSG00000234046.
DR Ensembl; ENST00000425523; ENSP00000393011; ENSG00000228881.
DR Ensembl; ENST00000425831; ENSP00000394371; ENSG00000231641.
DR Ensembl; ENST00000427535; ENSP00000398545; ENSG00000234046.
DR Ensembl; ENST00000428486; ENSP00000414248; ENSG00000231002.
DR Ensembl; ENST00000432326; ENSP00000407876; ENSG00000231641.
DR Ensembl; ENST00000433314; ENSP00000402395; ENSG00000226060.
DR Ensembl; ENST00000436219; ENSP00000390258; ENSG00000230230.
DR Ensembl; ENST00000437089; ENSP00000395491; ENSG00000234127.
DR Ensembl; ENST00000438384; ENSP00000416737; ENSG00000231641.
DR Ensembl; ENST00000438908; ENSP00000409182; ENSG00000230230.
DR Ensembl; ENST00000439094; ENSP00000389203; ENSG00000228881.
DR Ensembl; ENST00000445259; ENSP00000407294; ENSG00000234046.
DR Ensembl; ENST00000447711; ENSP00000408233; ENSG00000226060.
DR Ensembl; ENST00000450392; ENSP00000394421; ENSG00000231002.
DR Ensembl; ENST00000453195; ENSP00000391879; ENSG00000234127.
DR Ensembl; ENST00000454678; ENSP00000410446; ENSG00000234127.
DR Ensembl; ENST00000455000; ENSP00000392805; ENSG00000230230.
DR Ensembl; ENST00000456093; ENSP00000406707; ENSG00000226060.
DR Ensembl; ENST00000456770; ENSP00000415328; ENSG00000228881.
DR GeneID; 7726; -.
DR KEGG; hsa:7726; -.
DR UCSC; uc003npr.3; human.
DR CTD; 7726; -.
DR DisGeNET; 7726; -.
DR GeneCards; TRIM26; -.
DR HGNC; HGNC:12962; TRIM26.
DR HPA; HPA044975; -.
DR HPA; HPA050456; -.
DR MIM; 600830; gene.
DR neXtProt; NX_Q12899; -.
DR OpenTargets; ENSG00000137313; -.
DR OpenTargets; ENSG00000226060; -.
DR OpenTargets; ENSG00000228881; -.
DR OpenTargets; ENSG00000230230; -.
DR OpenTargets; ENSG00000231002; -.
DR OpenTargets; ENSG00000231641; -.
DR OpenTargets; ENSG00000234046; -.
DR OpenTargets; ENSG00000234127; -.
DR PharmGKB; PA37544; -.
DR eggNOG; KOG2177; Eukaryota.
DR eggNOG; ENOG410Z766; LUCA.
DR GeneTree; ENSGT00760000118893; -.
DR HOGENOM; HOG000234133; -.
DR HOVERGEN; HBG001357; -.
DR InParanoid; Q12899; -.
DR KO; K12008; -.
DR OMA; GREKFKT; -.
DR OrthoDB; EOG091G0AKN; -.
DR PhylomeDB; Q12899; -.
DR TreeFam; TF342569; -.
DR BioCyc; ZFISH:ENSG00000137313-MONOMER; -.
DR Reactome; R-HSA-877300; Interferon gamma signaling.
DR ChiTaRS; TRIM26; human.
DR GenomeRNAi; 7726; -.
DR PRO; PR:Q12899; -.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000137313; -.
DR CleanEx; HS_TRIM26; -.
DR ExpressionAtlas; Q12899; baseline and differential.
DR Genevisible; Q12899; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; NAS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IDA:UniProtKB.
DR GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
DR GO; GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB.
DR GO; GO:1902187; P:negative regulation of viral release from host cell; IDA:UniProtKB.
DR GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
DR Gene3D; 3.30.40.10; -; 1.
DR Gene3D; 4.10.45.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR003879; Butyrophylin.
DR InterPro; IPR013320; ConA-like_dom.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Metal-binding; Polymorphism;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1 539 Tripartite motif-containing protein 26.
FT /FTId=PRO_0000056235.
FT DOMAIN 295 539 B30.2/SPRY. {ECO:0000255|PROSITE-
FT ProRule:PRU00548}.
FT ZN_FING 16 57 RING-type. {ECO:0000255|PROSITE-
FT ProRule:PRU00175}.
FT ZN_FING 97 138 B box-type. {ECO:0000255|PROSITE-
FT ProRule:PRU00024}.
FT COILED 188 227 {ECO:0000255}.
FT COMPBIAS 388 400 Poly-Glu.
FT COMPBIAS 422 432 Poly-Glu.
FT VARIANT 197 197 Q -> H (in dbSNP:rs17194565).
FT /FTId=VAR_052138.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 435 530 ipfam:SPRY [T]
FT MYHIT 99 136 ipfam:zf-B_box [T]
FT MYHIT 16 57 iprf:ZF_RING_2 [T]
FT MYHIT 295 539 iprf:B302_SPRY [T]
FT MYHIT 315 363 ipfam:PRY [T]
FT MYHIT 365 539 ismart:SPRY [T]
FT MYHIT 312 364 ismart:PRY [T]
FT MYHIT 16 56 ismart:RING [T]
FT MYHIT 97 138 iprf:ZF_BBOX [T]
FT MYHIT 97 138 ismart:BBOX [T]
SQ SEQUENCE 539 AA; 62166 MW; 842A71C41F2E2348 CRC64;
MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF
KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL
CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK
LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS
ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF
QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS
KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG
DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL
FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP
//
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