Entry sw:TR49D_HUMAN

ID   TR49D_HUMAN             Reviewed;         452 AA.
AC   C9J1S8; I1YAP9;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   02-NOV-2016, entry version 67.
DE   RecName: Full=Tripartite motif-containing protein 49D {ECO:0000305};
DE   AltName: Full=Tripartite motif-containing protein 49-like protein;
DE   AltName: Full=Tripartite motif-containing protein 49D1 {ECO:0000312|HGNC:HGNC:43973};
DE   AltName: Full=Tripartite motif-containing protein 49D2 {ECO:0000312|HGNC:HGNC:37217};
GN   Name=TRIM49D1 {ECO:0000312|HGNC:HGNC:43973};
GN   Synonyms=TRIM49L, TRIM49L1;
GN   and
GN   Name=TRIM49D2 {ECO:0000312|HGNC:HGNC:37217}; Synonyms=TRIM49D2P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-229.
RA   Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT   "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT   human.";
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 222-303.
RX   PubMed=22144910; DOI=10.1371/journal.pgen.1002388;
RA   Han K., Lou D.I., Sawyer S.L.;
RT   "Identification of a genomic reservoir for new TRIM genes in primate
RT   genomes.";
RL   PLoS Genet. 7:E1002388-E1002388(2011).
CC   -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 B box-type zinc finger.
CC       {ECO:0000255|PROSITE-ProRule:PRU00024}.
CC   -!- SIMILARITY: Contains 1 B30.2/SPRY domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00548}.
CC   -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC       {ECO:0000255|PROSITE-ProRule:PRU00175}.
CC   -!- CAUTION: The two loci are in opposite orientation. {ECO:0000305}.
DR   EMBL; AP004607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DW009626; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; JF968447; AFI99090.1; -; mRNA.
DR   EMBL; JF968448; AFI99091.1; -; mRNA.
DR   CCDS; CCDS60930.1; -.
DR   RefSeq; NP_001098992.1; NM_001105522.1.
DR   RefSeq; NP_001193556.1; NM_001206627.1.
DR   RefSeq; XP_011541118.1; XM_011542816.2.
DR   UniGene; Hs.448674; -.
DR   UniGene; Hs.705301; -.
DR   ProteinModelPortal; C9J1S8; -.
DR   SMR; C9J1S8; -.
DR   iPTMnet; C9J1S8; -.
DR   PhosphoSitePlus; C9J1S8; -.
DR   BioMuta; TRIM49D1; -.
DR   PRIDE; C9J1S8; -.
DR   Ensembl; ENST00000420869; ENSP00000474678; ENSG00000223417.
DR   Ensembl; ENST00000526396; ENSP00000485325; ENSG00000233802.
DR   Ensembl; ENST00000530311; ENSP00000474850; ENSG00000223417.
DR   Ensembl; ENST00000623787; ENSP00000485097; ENSG00000233802.
DR   GeneID; 399939; -.
DR   GeneID; 729384; -.
DR   KEGG; hsa:399939; -.
DR   KEGG; hsa:729384; -.
DR   UCSC; uc009yvu.4; human.
DR   CTD; 399939; -.
DR   CTD; 729384; -.
DR   GeneCards; TRIM49D1; -.
DR   HGNC; HGNC:43973; TRIM49D1.
DR   HGNC; HGNC:37217; TRIM49D2.
DR   neXtProt; NX_C9J1S8; -.
DR   OpenTargets; ENSG00000223417; -.
DR   OpenTargets; ENSG00000233802; -.
DR   PharmGKB; PA165543723; -.
DR   GeneTree; ENSGT00840000129725; -.
DR   InParanoid; C9J1S8; -.
DR   KO; K12019; -.
DR   OMA; CFECLKT; -.
DR   OrthoDB; EOG091G05RG; -.
DR   PhylomeDB; C9J1S8; -.
DR   PRO; PR:C9J1S8; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   ExpressionAtlas; C9J1S8; baseline and differential.
DR   Genevisible; C9J1S8; HS.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 4.10.45.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR003879; Butyrophylin.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Metal-binding; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    452       Tripartite motif-containing protein 49D.
FT                                /FTId=PRO_0000395402.
FT   DOMAIN      269    452       B30.2/SPRY. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00548}.
FT   ZN_FING      15     56       RING-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00175}.
FT   ZN_FING      88    129       B box-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00024}.
FT   CONFLICT    207    207       D -> E (in Ref. 2; DW009626).
FT                                {ECO:0000305}.
FT   CONFLICT    213    213       H -> K (in Ref. 2; DW009626).
FT                                {ECO:0000305}.
CC   --------------------------------------------------------------------------
CC   The following FT lines are automated annotations from the MyHits database.
CC   --------------------------------------------------------------------------
FT   MYHIT       269    452       iprf:B302_SPRY [T]
FT   MYHIT        88    129       ismart:BBOX [T]
FT   MYHIT        88    129       iprf:ZF_BBOX [T]
FT   MYHIT       340    449       ipfam:SPRY [T]
FT   MYHIT        89    128       ipfam:zf-B_box [T]
FT   MYHIT        15     55       ismart:RING [T]
FT   MYHIT        15     55       iprf:ZF_RING_2 [T]
FT   MYHIT       338    451       ismart:SPRY [T]
SQ   SEQUENCE   452 AA;  52496 MW;  68364723E20D0DA5 CRC64;
     MNSGISQVFQ RELTCPICLN YFIDPVTIDC GHSFCRPCFY LNWQDIPILT QCFECLKTTQ
     QRNLKTNIRL KKMASRARKA SLWLFLSSEE QMCGTHRETK KIFCEVDRSL LCLLCSSSLE
     HRYHRHCPAE WAAEEHREKL LKKMQSLWEK VCENQRNLNV ETTRISHWKD YVNVRLEAIR
     AEYQKMPAFH HEEEKHNLEM LKKKGKDIFH RLHLSKAKMA HRREILRGTY AELMKMCHKP
     DVELLQAFGD ILHRSESVLL HMPQPLNLEL RAGPITGLRD RLNQFRVDIT LPHNEANSHI
     FRRGDLRSIC IGCDRQNAPH ITATPTSFLA WGAQTFTSGK YYWEVHVGDS WNWAFGVCNK
     YWKGTNQNGN IHGEEGLFSL GCVKNDIQCS LFTTSPLTLQ YVPRPTNHVG LFLDCEARTV
     SFVDVNQSSP IHTIPNCSFS PPLRPIFCCV HL
//