Legends: 1, N-linked (GlcNAc...). {ECO:0000255}; 2, TOPO_DOM Extracellular. {ECO:0000255}; 3, TRANSMEM Helical; Name=1. {ECO:0000255}; 4, TOPO_DOM Cytoplasmic. {ECO:0000255}; 5, TRANSMEM Helical; Name=2. {ECO:0000255}; 6, TRANSMEM Helical; Name=3. {ECO:0000255}; 7, TRANSMEM Helical; Name=4. {ECO:0000255}; 8, TRANSMEM Helical; Name=5. {ECO:0000255}; 9, TRANSMEM Helical; Name=6. {ECO:0000255}; 10, TRANSMEM Helical; Name=7. {ECO:0000255}.
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ID TR134_RAT Reviewed; 329 AA.
AC Q67ES7; Q4VHE8;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 07-SEP-2016, entry version 69.
DE RecName: Full=Taste receptor type 2 member 134;
DE Short=T2R134;
DE Short=T2R34;
DE AltName: Full=Taste receptor type 2 member 23;
DE Short=T2R23;
GN Name=Tas2r134 {ECO:0000312|RGD:1359393}; Synonyms=Tas2r23, Tas2r34;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAR13352.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13352.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the
RT T2R family.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAX99134.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 28-329, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000269|PubMed:15886333};
RC TISSUE=Gastrointestinal tract {ECO:0000269|PubMed:15886333};
RX PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
RA Wu S.V., Chen M.C., Rozengurt E.;
RT "Genomic organization, expression, and function of bitter taste
RT receptors (T2R) in mouse and rat.";
RL Physiol. Genomics 22:139-149(2005).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in tongue and gastrointestinal
CC tract. {ECO:0000269|PubMed:15886333}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
CC single taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX99134.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR EMBL; AY362743; AAR13352.1; -; Genomic_DNA.
DR EMBL; AY916511; AAX99134.1; ALT_INIT; mRNA.
DR RefSeq; NP_001013937.1; NM_001013915.1.
DR UniGene; Rn.143008; -.
DR ProteinModelPortal; Q67ES7; -.
DR STRING; 10116.ENSRNOP00000038705; -.
DR PaxDb; Q67ES7; -.
DR PRIDE; Q67ES7; -.
DR Ensembl; ENSRNOT00000030442; ENSRNOP00000038705; ENSRNOG00000027510.
DR GeneID; 295589; -.
DR KEGG; rno:295589; -.
DR UCSC; RGD:1359393; rat.
DR CTD; 387511; -.
DR RGD; 1359393; Tas2r134.
DR eggNOG; ENOG410IKNW; Eukaryota.
DR eggNOG; ENOG41119UD; LUCA.
DR GeneTree; ENSGT00760000119096; -.
DR HOGENOM; HOG000234595; -.
DR HOVERGEN; HBG098568; -.
DR InParanoid; Q67ES7; -.
DR KO; K08474; -.
DR OMA; YANICLH; -.
DR OrthoDB; EOG091G0FYT; -.
DR PhylomeDB; Q67ES7; -.
DR TreeFam; TF335891; -.
DR PRO; PR:Q67ES7; -.
DR Proteomes; UP000002494; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:MGI.
DR InterPro; IPR007960; T2R.
DR PANTHER; PTHR11394; PTHR11394; 1.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 329 Taste receptor type 2 member 134.
FT /FTId=PRO_0000247661.
FT TOPO_DOM 1 27 Extracellular. {ECO:0000255}.
FT TRANSMEM 28 48 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 49 68 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 69 89 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 90 121 Extracellular. {ECO:0000255}.
FT TRANSMEM 122 142 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 143 153 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 154 174 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 175 201 Extracellular. {ECO:0000255}.
FT TRANSMEM 202 222 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 223 251 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 252 272 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 273 282 Extracellular. {ECO:0000255}.
FT TRANSMEM 283 303 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 304 329 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 183 183 N-linked (GlcNAc...). {ECO:0000255}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 32 312 ipfam:TAS2R [T]
SQ SEQUENCE 329 AA; 38062 MW; 90CAEB5330BDA7F4 CRC64;
MRCSLRGCVQ GRGGKSGVSL SKFSPKKMSF FFIFMVIFCI QSLVALLQNG FLATVLGREW
VRSQGLPAGD MIVACLAASR FCLHGVAIVN NFLTFVKLWS QKIYFSVLWD FVNTVNFWCT
TWLAIFYCVK ISSFSHPIFF WIKWRISRSV PRLLLGSLVI GGLSAVSSAT GNTIAFQMTA
CENYTLAYRT RAFYAYYFRC HAMLMWIIPF FLFLLSVILL MFSLYRHLEH MRYRRPWSHD
YSTQAHTMAL KSLAFFLVFY TSYVLFLVIS VTRVVNVHSS WHWAWEVITY MGILLHSTIL
TLSNPKMRKA LKIKFPDLCV ARSQDKRRG
//
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