Legends: 1, N-linked (GlcNAc...). {ECO:0000255}; 2, CONFLICT W -> C (in Ref. 2; AAX99131). {ECO:0000305}; 3, CONFLICT M -> T (in Ref. 2; AAX99131). {ECO:0000305}; 4, CONFLICT T -> A (in Ref. 2; AAX99131). {ECO:0000305}; 5, CONFLICT T -> M (in Ref. 2; AAX99131). {ECO:0000305}; 6, CONFLICT K -> M (in Ref. 2; AAX99131). {ECO:0000305}; 7, TOPO_DOM Extracellular. {ECO:0000255}; 8, TRANSMEM Helical; Name=1. {ECO:0000255}; 9, TOPO_DOM Cytoplasmic. {ECO:0000255}; 10, TRANSMEM Helical; Name=2. {ECO:0000255}; 11, TRANSMEM Helical; Name=3. {ECO:0000255}; 12, TRANSMEM Helical; Name=4. {ECO:0000255}; 13, TRANSMEM Helical; Name=5. {ECO:0000255}; 14, TRANSMEM Helical; Name=6. {ECO:0000255}; 15, TRANSMEM Helical; Name=7. {ECO:0000255}.
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ID TR134_MOUSE Reviewed; 298 AA.
AC Q7TQB0; Q4VHF1;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 02-NOV-2016, entry version 85.
DE RecName: Full=Taste receptor type 2 member 134;
DE Short=T2R134;
DE AltName: Full=Taste receptor type 2 member 34;
DE Short=T2R34;
GN Name=Tas2r134; Synonyms=Tas2r34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40335.1};
RN [1] {ECO:0000312|EMBL:AAP40335.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40335.1};
RX PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Evolutionary relationships of the Tas2r receptor gene families in
RT mouse and human.";
RL Physiol. Genomics 14:73-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
RA Wu S.V., Chen M.C., Rozengurt E.;
RT "Genomic organization, expression, and function of bitter taste
RT receptors (T2R) in mouse and rat.";
RL Physiol. Genomics 22:139-149(2005).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000303|PubMed:12734386}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a
CC single taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
DR EMBL; AF532785; AAP40335.1; -; Genomic_DNA.
DR EMBL; AY916508; AAX99131.1; -; mRNA.
DR CCDS; CCDS16029.1; -.
DR RefSeq; NP_954609.1; NM_199158.1.
DR UniGene; Mm.377918; -.
DR ProteinModelPortal; Q7TQB0; -.
DR STRING; 10090.ENSMUSP00000064657; -.
DR PaxDb; Q7TQB0; -.
DR PRIDE; Q7TQB0; -.
DR DNASU; 387511; -.
DR Ensembl; ENSMUST00000070028; ENSMUSP00000064657; ENSMUSG00000056115.
DR GeneID; 387511; -.
DR KEGG; mmu:387511; -.
DR UCSC; uc008jqj.1; mouse.
DR CTD; 387511; -.
DR MGI; MGI:2681300; Tas2r134.
DR eggNOG; ENOG410IKNW; Eukaryota.
DR eggNOG; ENOG41119UD; LUCA.
DR GeneTree; ENSGT00760000119096; -.
DR HOGENOM; HOG000234595; -.
DR HOVERGEN; HBG098568; -.
DR InParanoid; Q7TQB0; -.
DR KO; K08474; -.
DR OMA; QAHIMAL; -.
DR OrthoDB; EOG091G0FYT; -.
DR PhylomeDB; Q7TQB0; -.
DR TreeFam; TF335891; -.
DR PRO; PR:Q7TQB0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR CleanEx; MM_TAS2R134; -.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; NAS:UniProtKB.
DR InterPro; IPR007960; T2R.
DR PANTHER; PTHR11394; PTHR11394; 1.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Sensory transduction; Taste; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 298 Taste receptor type 2 member 134.
FT /FTId=PRO_0000082269.
FT TOPO_DOM 1 6 Extracellular. {ECO:0000255}.
FT TRANSMEM 7 27 Helical; Name=1. {ECO:0000255}.
FT TOPO_DOM 28 55 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 56 76 Helical; Name=2. {ECO:0000255}.
FT TOPO_DOM 77 96 Extracellular. {ECO:0000255}.
FT TRANSMEM 97 117 Helical; Name=3. {ECO:0000255}.
FT TOPO_DOM 118 128 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 129 149 Helical; Name=4. {ECO:0000255}.
FT TOPO_DOM 150 176 Extracellular. {ECO:0000255}.
FT TRANSMEM 177 197 Helical; Name=5. {ECO:0000255}.
FT TOPO_DOM 198 229 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 230 250 Helical; Name=6. {ECO:0000255}.
FT TOPO_DOM 251 257 Extracellular. {ECO:0000255}.
FT TRANSMEM 258 278 Helical; Name=7. {ECO:0000255}.
FT TOPO_DOM 279 298 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 158 158 N-linked (GlcNAc...). {ECO:0000255}.
FT CONFLICT 97 97 W -> C (in Ref. 2; AAX99131).
FT {ECO:0000305}.
FT CONFLICT 165 165 M -> T (in Ref. 2; AAX99131).
FT {ECO:0000305}.
FT CONFLICT 239 239 T -> A (in Ref. 2; AAX99131).
FT {ECO:0000305}.
FT CONFLICT 243 243 T -> M (in Ref. 2; AAX99131).
FT {ECO:0000305}.
FT CONFLICT 287 287 K -> M (in Ref. 2; AAX99131).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 1 287 ipfam:TAS2R [T]
SQ SEQUENCE 298 AA; 34628 MW; 0F0701A66EC379C3 CRC64;
MSFSHSFIFI VIFCMQSLAA LLQNGFMATV LGREWVRSQG LPAGDMIMAC LAASRFCLHG
IAVLNNFLAS AMFWTIKNYF SILWDFTNTV NFWFTTWLAI FYCVKISSFS HPIFFWIKWR
ISRSVPRLLL GSLIIGGLSA ISSATGNTIA LQMAACENYT IYYKMMAFYL YYFRCHAMLM
WVIPFFLFLL SIILLMFSLY RHLEQMRYHR PRTHDYSTQA HIMALKSLAF FLIFYTSYTL
LLTVSVAHVI NVHGSWHWAW EVVTYMGISL HSTILILSNT KMRKALKIKF PDLCIPRS
//
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