ID TM251_DANRE Reviewed; 142 AA.
AC Q5TZA3; Q4V9J4;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 05-OCT-2016, entry version 65.
DE RecName: Full=Transmembrane protein 251;
GN Name=tmem251; ORFNames=si:dkeyp-55f12.4, zgc:112233;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Intestine;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM251 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH96869.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
DR EMBL; BX284625; CAH69134.1; -; Genomic_DNA.
DR EMBL; BC096869; AAH96869.1; ALT_INIT; mRNA.
DR RefSeq; NP_001028918.1; NM_001033746.1.
DR UniGene; Dr.76408; -.
DR PaxDb; Q5TZA3; -.
DR Ensembl; ENSDART00000062094; ENSDARP00000062093; ENSDARG00000042341.
DR GeneID; 619265; -.
DR KEGG; dre:619265; -.
DR CTD; 26175; -.
DR ZFIN; ZDB-GENE-041001-121; tmem251.
DR eggNOG; ENOG410IVYY; Eukaryota.
DR eggNOG; ENOG4111FFW; LUCA.
DR GeneTree; ENSGT00390000007473; -.
DR HOGENOM; HOG000111822; -.
DR HOVERGEN; HBG058826; -.
DR InParanoid; Q5TZA3; -.
DR OMA; LPFWFWT; -.
DR OrthoDB; EOG091G14P1; -.
DR PhylomeDB; Q5TZA3; -.
DR TreeFam; TF332722; -.
DR PRO; PR:Q5TZA3; -.
DR Proteomes; UP000000437; Chromosome 20.
DR Bgee; ENSDARG00000042341; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028024; TMEM251.
DR Pfam; PF15190; TMEM251; 1.
DR ProDom; PD641273; PD641273; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 142 Transmembrane protein 251.
FT /FTId=PRO_0000359885.
FT TRANSMEM 8 28 Helical. {ECO:0000255}.
FT TRANSMEM 76 96 Helical. {ECO:0000255}.
FT COMPBIAS 57 65 Poly-Ser.
FT CONFLICT 100 100 C -> R (in Ref. 2; AAH96869).
FT {ECO:0000305}.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 2 140 ipfam:TMEM251 [T]
SQ SEQUENCE 142 AA; 16080 MW; C915C46ADA0E7B12 CRC64;
MMNFRQRMGW IGVGLYLLAS VAAVYYIFEI SQTYNRLALA QVEKTSGAQA KWPGDASSSS
PSSTSWIVTL KTRLLLLPFW VWATIFLLPY LQVFLFLYSC TRADPKTVGY CILPICLAVL
CNRHQTFTKA SNQISRLQLI DT
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