ID TM244_HUMAN Reviewed; 128 AA.
AC Q5VVB8;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 02-NOV-2016, entry version 79.
DE RecName: Full=Transmembrane protein 244;
GN Name=TMEM244; Synonyms=C6orf191;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
DR EMBL; AL451046; CAH70899.1; -; Genomic_DNA.
DR CCDS; CCDS34536.1; -.
DR RefSeq; NP_001010876.1; NM_001010876.1.
DR UniGene; Hs.448372; -.
DR ProteinModelPortal; Q5VVB8; -.
DR BioMuta; TMEM244; -.
DR DMDM; 74747217; -.
DR PaxDb; Q5VVB8; -.
DR PeptideAtlas; Q5VVB8; -.
DR PRIDE; Q5VVB8; -.
DR TopDownProteomics; Q5VVB8; -.
DR Ensembl; ENST00000368143; ENSP00000357125; ENSG00000203756.
DR Ensembl; ENST00000438392; ENSP00000403755; ENSG00000203756.
DR GeneID; 253582; -.
DR KEGG; hsa:253582; -.
DR UCSC; uc003qbs.3; human.
DR CTD; 253582; -.
DR DisGeNET; 253582; -.
DR GeneCards; TMEM244; -.
DR HGNC; HGNC:21571; TMEM244.
DR HPA; HPA045247; -.
DR neXtProt; NX_Q5VVB8; -.
DR OpenTargets; ENSG00000203756; -.
DR PharmGKB; PA134909151; -.
DR eggNOG; ENOG410J003; Eukaryota.
DR eggNOG; ENOG410YMZT; LUCA.
DR GeneTree; ENSGT00390000007791; -.
DR HOGENOM; HOG000007700; -.
DR HOVERGEN; HBG057717; -.
DR InParanoid; Q5VVB8; -.
DR OMA; WDYAILV; -.
DR OrthoDB; EOG091G0M6R; -.
DR PhylomeDB; Q5VVB8; -.
DR TreeFam; TF340485; -.
DR BioCyc; ZFISH:G66-32512-MONOMER; -.
DR GenomeRNAi; 253582; -.
DR PRO; PR:Q5VVB8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000203756; -.
DR CleanEx; HS_C6orf191; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 4: Predicted;
KW Complete proteome; Membrane; Polymorphism; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 128 Transmembrane protein 244.
FT /FTId=PRO_0000238467.
FT TRANSMEM 17 37 Helical. {ECO:0000255}.
FT TRANSMEM 65 85 Helical. {ECO:0000255}.
FT TRANSMEM 93 113 Helical. {ECO:0000255}.
FT VARIANT 60 60 N -> I (in dbSNP:rs7760577).
FT /FTId=VAR_033681.
FT VARIANT 80 80 F -> L (in dbSNP:rs4629709).
FT /FTId=VAR_026549.
FT VARIANT 86 86 E -> G (in dbSNP:rs9492393).
FT /FTId=VAR_026550.
FT VARIANT 111 111 F -> V (in dbSNP:rs7776426).
FT /FTId=VAR_026551.
SQ SEQUENCE 128 AA; 14657 MW; 9AB7F28C72185C38 CRC64;
MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF DFKTNPSWLN
INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH VAITSTVMLE FPLTSHWWAA
LGISKLLV
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