ID TM223_MOUSE Reviewed; 199 AA.
AC Q9CQE2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 30-NOV-2016, entry version 99.
DE RecName: Full=Transmembrane protein 223;
GN Name=Tmem223;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Kidney, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM223 family. {ECO:0000305}.
DR EMBL; AK002249; BAB21964.1; -; mRNA.
DR EMBL; AK003417; BAB22778.1; -; mRNA.
DR EMBL; AK008282; BAB25573.1; -; mRNA.
DR EMBL; AK008327; BAB25605.1; -; mRNA.
DR EMBL; AK160470; BAE35807.1; -; mRNA.
DR EMBL; BC066781; AAH66781.1; -; mRNA.
DR CCDS; CCDS29544.1; -.
DR RefSeq; NP_080067.1; NM_025791.1.
DR UniGene; Mm.440071; -.
DR ProteinModelPortal; Q9CQE2; -.
DR STRING; 10090.ENSMUSP00000010248; -.
DR MaxQB; Q9CQE2; -.
DR PaxDb; Q9CQE2; -.
DR PeptideAtlas; Q9CQE2; -.
DR PRIDE; Q9CQE2; -.
DR Ensembl; ENSMUST00000010248; ENSMUSP00000010248; ENSMUSG00000010097.
DR GeneID; 66836; -.
DR KEGG; mmu:66836; -.
DR UCSC; uc008gms.1; mouse.
DR CTD; 79064; -.
DR MGI; MGI:1914086; Tmem223.
DR eggNOG; ENOG410IWJD; Eukaryota.
DR eggNOG; ENOG4111M6M; LUCA.
DR GeneTree; ENSGT00390000007539; -.
DR HOGENOM; HOG000008386; -.
DR InParanoid; Q9CQE2; -.
DR PhylomeDB; Q9CQE2; -.
DR TreeFam; TF324862; -.
DR Reactome; R-MMU-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR PRO; PR:Q9CQE2; -.
DR Proteomes; UP000000589; Chromosome 19.
DR Bgee; ENSMUSG00000075043; -.
DR CleanEx; MM_0610006I08RIK; -.
DR ExpressionAtlas; Q9CQE2; baseline and differential.
DR Genevisible; Q9CQE2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR GO; GO:0042405; C:nuclear inclusion body; IEA:Ensembl.
DR GO; GO:0005643; C:nuclear pore; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR GO; GO:0005487; F:nucleocytoplasmic transporter activity; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:Ensembl.
DR InterPro; IPR026100; Tmem223.
DR PANTHER; PTHR14549; PTHR14549; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 199 Transmembrane protein 223.
FT /FTId=PRO_0000321834.
FT TRANSMEM 44 64 Helical. {ECO:0000255}.
FT TRANSMEM 95 115 Helical. {ECO:0000255}.
SQ SEQUENCE 199 AA; 21857 MW; 992A84ACC159A5A1 CRC64;
MVASVPLRNV SHLLSVLRSQ NVPRYLQNGV PRDVLLFRHE RGRFFAILGL FCAGQGIFWT
SLAVAALSRP LSRVPAEAPN RSYQDLRSAL WRYGLAVGCG TMGVLVLGAG LLYSLRSVRS
VMLLAGGQQV TLTTYAPFGL GTCFTVPLNQ ISCMAHRGEV PAMLPLKVKG RRFYFLLDKA
GHFPNTQLFD NTVGAYRSL
//
|
