ID TM204_RAT Reviewed; 226 AA.
AC Q5M962;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 30-NOV-2016, entry version 75.
DE RecName: Full=Transmembrane protein 204;
DE AltName: Full=Claudin-like protein 24;
GN Name=Tmem204; Synonyms=Clp24;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Can influence paracellular permeability. Appears to be
CC involved in cell-cell interactions through adherens (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell
CC membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC Note=Co-localizes with the beta-catenin adherins. {ECO:0000250}.
DR EMBL; BC087601; AAH87601.1; -; mRNA.
DR RefSeq; NP_001009620.1; NM_001009620.1.
DR RefSeq; XP_017452554.1; XM_017597065.1.
DR UniGene; Rn.16780; -.
DR STRING; 10116.ENSRNOP00000022142; -.
DR PaxDb; Q5M962; -.
DR PRIDE; Q5M962; -.
DR Ensembl; ENSRNOT00000022142; ENSRNOP00000022142; ENSRNOG00000016494.
DR GeneID; 287129; -.
DR KEGG; rno:287129; -.
DR UCSC; RGD:1359314; rat.
DR CTD; 79652; -.
DR RGD; 1359314; Tmem204.
DR eggNOG; ENOG410IEHK; Eukaryota.
DR eggNOG; ENOG410XRFW; LUCA.
DR GeneTree; ENSGT00390000015528; -.
DR HOGENOM; HOG000030900; -.
DR HOVERGEN; HBG081251; -.
DR InParanoid; Q5M962; -.
DR OMA; SQCWEEA; -.
DR OrthoDB; EOG091G0LZU; -.
DR PhylomeDB; Q5M962; -.
DR TreeFam; TF331492; -.
DR PRO; PR:Q5M962; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000016494; -.
DR Genevisible; Q5M962; RN.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001945; P:lymph vessel development; IBA:GO_Central.
DR GO; GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051145; P:smooth muscle cell differentiation; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Complete proteome; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 226 Transmembrane protein 204.
FT /FTId=PRO_0000089867.
FT TOPO_DOM 1 5 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 6 26 Helical. {ECO:0000255}.
FT TOPO_DOM 27 103 Extracellular. {ECO:0000255}.
FT TRANSMEM 104 124 Helical. {ECO:0000255}.
FT TOPO_DOM 125 136 Cytoplasmic. {ECO:0000255}.
FT TRANSMEM 137 157 Helical. {ECO:0000255}.
FT TOPO_DOM 158 170 Extracellular. {ECO:0000255}.
FT TRANSMEM 171 191 Helical. {ECO:0000255}.
FT TOPO_DOM 192 226 Cytoplasmic. {ECO:0000255}.
FT CARBOHYD 164 164 N-linked (GlcNAc...). {ECO:0000255}.
SQ SEQUENCE 226 AA; 24701 MW; 24E18378EE501969 CRC64;
MTVQKLVATA VLVALVSLIL NNAAAFTPNW VYQTLEDGRK RSVGLWKSCW LVDRGKGGTS
PGTRTGQVDT HDCEVLGWGS ESAGFQESRG TVKLQFDMMR ACNLVATAAL AVGQITFILG
LTGLPLMSPE SQCWEEAMAA AFQLASFVLV IGLVTFYRIG PYTNLSWSCY LNIGACLLAT
LAAAMLIWNI LHRREDCMAP RVIVISRSLT ARFRRGLDND YVESPC
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