ID TM174_HUMAN Reviewed; 243 AA.
AC Q8WUU8; B2RDA0; Q96N81;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 30-NOV-2016, entry version 93.
DE RecName: Full=Transmembrane protein 174;
GN Name=TMEM174;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=20331980; DOI=10.1016/j.bbrc.2010.03.109;
RA Wang P., Sun B., Hao D., Zhang X., Shi T., Ma D.;
RT "Human TMEM174 that is highly expressed in kidney tissue activates AP-
RT 1 and promotes cell proliferation.";
RL Biochem. Biophys. Res. Commun. 394:993-999(2010).
CC -!- INTERACTION:
CC O43765:SGTA; NbExp=3; IntAct=EBI-10276729, EBI-347996;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:20331980}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:20331980}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WUU8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WUU8-2; Sequence=VSP_024210;
CC Note=No experimental confirmation available.;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in kidney.
CC {ECO:0000269|PubMed:20331980}.
DR EMBL; AK055830; BAB71025.1; -; mRNA.
DR EMBL; AK315460; BAG37847.1; -; mRNA.
DR EMBL; CH471084; EAW95719.1; -; Genomic_DNA.
DR EMBL; BC019346; AAH19346.1; -; mRNA.
DR CCDS; CCDS4018.1; -. [Q8WUU8-1]
DR RefSeq; NP_694949.1; NM_153217.2. [Q8WUU8-1]
DR UniGene; Hs.508588; -.
DR ProteinModelPortal; Q8WUU8; -.
DR BioGrid; 126393; 2.
DR IntAct; Q8WUU8; 3.
DR PhosphoSitePlus; Q8WUU8; -.
DR BioMuta; TMEM174; -.
DR DMDM; 74730764; -.
DR PaxDb; Q8WUU8; -.
DR PRIDE; Q8WUU8; -.
DR DNASU; 134288; -.
DR Ensembl; ENST00000296776; ENSP00000296776; ENSG00000164325. [Q8WUU8-1]
DR GeneID; 134288; -.
DR KEGG; hsa:134288; -.
DR UCSC; uc010izc.4; human. [Q8WUU8-1]
DR CTD; 134288; -.
DR DisGeNET; 134288; -.
DR GeneCards; TMEM174; -.
DR HGNC; HGNC:28187; TMEM174.
DR HPA; HPA037975; -.
DR MIM; 614909; gene.
DR neXtProt; NX_Q8WUU8; -.
DR OpenTargets; ENSG00000164325; -.
DR PharmGKB; PA162405935; -.
DR eggNOG; ENOG410IR9J; Eukaryota.
DR eggNOG; ENOG410YMC9; LUCA.
DR GeneTree; ENSGT00390000004161; -.
DR HOGENOM; HOG000059655; -.
DR HOVERGEN; HBG095684; -.
DR InParanoid; Q8WUU8; -.
DR OMA; PPQYYTI; -.
DR OrthoDB; EOG091G0I7E; -.
DR PhylomeDB; Q8WUU8; -.
DR TreeFam; TF335512; -.
DR BioCyc; ZFISH:ENSG00000164325-MONOMER; -.
DR GenomeRNAi; 134288; -.
DR PRO; PR:Q8WUU8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR Bgee; ENSG00000164325; -.
DR CleanEx; HS_TMEM174; -.
DR ExpressionAtlas; Q8WUU8; baseline and differential.
DR Genevisible; Q8WUU8; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027835; TMEM174.
DR PANTHER; PTHR31020; PTHR31020; 1.
DR Pfam; PF15029; TMEM174; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Endoplasmic reticulum;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 243 Transmembrane protein 174.
FT /FTId=PRO_0000282577.
FT TRANSMEM 40 60 Helical. {ECO:0000255}.
FT TRANSMEM 73 93 Helical. {ECO:0000255}.
FT VAR_SEQ 210 243 PNPDVDQLEETQLEEEACACFSPPPYEEIYSLPR -> YGP
FT ILMLTS (in isoform 2).
FT {ECO:0000303|PubMed:14702039}.
FT /FTId=VSP_024210.
CC --------------------------------------------------------------------------
CC The following FT lines are automated annotations from the MyHits database.
CC --------------------------------------------------------------------------
FT MYHIT 9 240 ipfam:TMEM174 [T]
SQ SEQUENCE 243 AA; 26287 MW; 05A764F265B50258 CRC64;
MEQGSGRLED FPVNVFSVTP YTPSTADIQV SDDDKAGATL LFSGIFLGLV GITFTVMGWI
KYQGVSHFEW TQLLGPVLLS VGVTFILIAV CKFKMLSCQL CKESEERVPD SEQTPGGPSF
VFTGINQPIT FHGATVVQYI PPPYGSPEPM GINTSYLQSV VSPCGLITSG GAAAAMSSPP
QYYTIYPQDN SAFVVDEGCL SFTDGGNHRP NPDVDQLEET QLEEEACACF SPPPYEEIYS
LPR
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